Urinary N-acetyl - D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease: 1 year prospective cohort study

Hayne Cho Park, Jin Ho Hwang, Ah Young Kang, Han Ro, Myung Gyu Kim, Jung Nam An, Ji In Park, Seung Hyup Kim, Jaeseok Yang, Yun Kyu Oh, Kook Hwan Oh, Jung Woo Noh, Hae Il Cheong, Young Hwan Hwang, Curie Ahn

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Abstract

Background: Renal failure is one of the most serious complications associated with autosomal dominant polycystic kidney disease (ADPKD). To date, early markers have failed to predict renal function deterioration at the early stages. This 1-year prospective study evaluated N-acetyl - D-glucosaminidase (NAG) as a new surrogate marker for renal function in ADPKD. Methods. A total of 270 patients were enrolled in the study, and we measured urinary NAG, 2-microglobulin, neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) prospectively for 1year to compare their predictive values for renal function. Results: Baseline urinary NAG/Cr was negatively correlated with estimated glomerular filtration rate (GFR) (r 2 =0.153, P<0.001) and positively correlated with total kidney volume (TKV) (r 2 =0.113, P<0.001). Among other biomarkers, urinary NAG/Cr better discriminated patients with decreased renal function from those with conserved renal function, showing the largest area under the curve (AUC 0.794). Immunohistochemical study revealed strong staining along the cyst-lining epithelial cells as well as the nearby compressed tubular epithelial cells. However, both single and repeated measurements of urinary NAG/Cr failed to predict renal function decline in 1year. Conclusions: Urinary NAG/Cr may be a useful surrogate marker for renal function in ADPKD patients.

Original languageEnglish
Article number93
JournalBMC Nephrology
Volume13
Issue number1
DOIs
Publication statusPublished - 2012 Sep 3

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Keywords

  • Autosomal dominant polycystic kidney disease
  • Biomarkers
  • Renal function

ASJC Scopus subject areas

  • Nephrology

Cite this

Park, H. C., Hwang, J. H., Kang, A. Y., Ro, H., Kim, M. G., An, J. N., In Park, J., Kim, S. H., Yang, J., Oh, Y. K., Oh, K. H., Noh, J. W., Cheong, H. I., Hwang, Y. H., & Ahn, C. (2012). Urinary N-acetyl - D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease: 1 year prospective cohort study. BMC Nephrology, 13(1), [93]. https://doi.org/10.1186/1471-2369-13-93