Urinary N-acetyl - D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease: 1 year prospective cohort study

Hayne Cho Park, Jin Ho Hwang, Ah Young Kang, Han Ro, Myung-Gyu Kim, Jung Nam An, Ji In Park, Seung Hyup Kim, Jaeseok Yang, Yun Kyu Oh, Kook Hwan Oh, Jung Woo Noh, Hae Il Cheong, Young Hwan Hwang, Curie Ahn

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Renal failure is one of the most serious complications associated with autosomal dominant polycystic kidney disease (ADPKD). To date, early markers have failed to predict renal function deterioration at the early stages. This 1-year prospective study evaluated N-acetyl - D-glucosaminidase (NAG) as a new surrogate marker for renal function in ADPKD. Methods. A total of 270 patients were enrolled in the study, and we measured urinary NAG, 2-microglobulin, neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) prospectively for 1year to compare their predictive values for renal function. Results: Baseline urinary NAG/Cr was negatively correlated with estimated glomerular filtration rate (GFR) (r 2 =0.153, P<0.001) and positively correlated with total kidney volume (TKV) (r 2 =0.113, P<0.001). Among other biomarkers, urinary NAG/Cr better discriminated patients with decreased renal function from those with conserved renal function, showing the largest area under the curve (AUC 0.794). Immunohistochemical study revealed strong staining along the cyst-lining epithelial cells as well as the nearby compressed tubular epithelial cells. However, both single and repeated measurements of urinary NAG/Cr failed to predict renal function decline in 1year. Conclusions: Urinary NAG/Cr may be a useful surrogate marker for renal function in ADPKD patients.

Original languageEnglish
Article number93
JournalBMC Nephrology
Volume13
Issue number1
DOIs
Publication statusPublished - 2012 Sep 3
Externally publishedYes

Fingerprint

Autosomal Dominant Polycystic Kidney
Hexosaminidases
Cohort Studies
Biomarkers
Prospective Studies
Kidney
Area Under Curve
Epithelial Cells
Glomerular Filtration Rate
Renal Insufficiency
Cysts
Staining and Labeling

Keywords

  • Autosomal dominant polycystic kidney disease
  • Biomarkers
  • Renal function

ASJC Scopus subject areas

  • Nephrology

Cite this

Urinary N-acetyl - D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease : 1 year prospective cohort study. / Park, Hayne Cho; Hwang, Jin Ho; Kang, Ah Young; Ro, Han; Kim, Myung-Gyu; An, Jung Nam; In Park, Ji; Kim, Seung Hyup; Yang, Jaeseok; Oh, Yun Kyu; Oh, Kook Hwan; Noh, Jung Woo; Cheong, Hae Il; Hwang, Young Hwan; Ahn, Curie.

In: BMC Nephrology, Vol. 13, No. 1, 93, 03.09.2012.

Research output: Contribution to journalArticle

Park, HC, Hwang, JH, Kang, AY, Ro, H, Kim, M-G, An, JN, In Park, J, Kim, SH, Yang, J, Oh, YK, Oh, KH, Noh, JW, Cheong, HI, Hwang, YH & Ahn, C 2012, 'Urinary N-acetyl - D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease: 1 year prospective cohort study', BMC Nephrology, vol. 13, no. 1, 93. https://doi.org/10.1186/1471-2369-13-93
Park, Hayne Cho ; Hwang, Jin Ho ; Kang, Ah Young ; Ro, Han ; Kim, Myung-Gyu ; An, Jung Nam ; In Park, Ji ; Kim, Seung Hyup ; Yang, Jaeseok ; Oh, Yun Kyu ; Oh, Kook Hwan ; Noh, Jung Woo ; Cheong, Hae Il ; Hwang, Young Hwan ; Ahn, Curie. / Urinary N-acetyl - D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease : 1 year prospective cohort study. In: BMC Nephrology. 2012 ; Vol. 13, No. 1.
@article{bfeee7216f4645b09733f75a2ae41c91,
title = "Urinary N-acetyl - D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease: 1 year prospective cohort study",
abstract = "Background: Renal failure is one of the most serious complications associated with autosomal dominant polycystic kidney disease (ADPKD). To date, early markers have failed to predict renal function deterioration at the early stages. This 1-year prospective study evaluated N-acetyl - D-glucosaminidase (NAG) as a new surrogate marker for renal function in ADPKD. Methods. A total of 270 patients were enrolled in the study, and we measured urinary NAG, 2-microglobulin, neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) prospectively for 1year to compare their predictive values for renal function. Results: Baseline urinary NAG/Cr was negatively correlated with estimated glomerular filtration rate (GFR) (r 2 =0.153, P<0.001) and positively correlated with total kidney volume (TKV) (r 2 =0.113, P<0.001). Among other biomarkers, urinary NAG/Cr better discriminated patients with decreased renal function from those with conserved renal function, showing the largest area under the curve (AUC 0.794). Immunohistochemical study revealed strong staining along the cyst-lining epithelial cells as well as the nearby compressed tubular epithelial cells. However, both single and repeated measurements of urinary NAG/Cr failed to predict renal function decline in 1year. Conclusions: Urinary NAG/Cr may be a useful surrogate marker for renal function in ADPKD patients.",
keywords = "Autosomal dominant polycystic kidney disease, Biomarkers, Renal function",
author = "Park, {Hayne Cho} and Hwang, {Jin Ho} and Kang, {Ah Young} and Han Ro and Myung-Gyu Kim and An, {Jung Nam} and {In Park}, Ji and Kim, {Seung Hyup} and Jaeseok Yang and Oh, {Yun Kyu} and Oh, {Kook Hwan} and Noh, {Jung Woo} and Cheong, {Hae Il} and Hwang, {Young Hwan} and Curie Ahn",
year = "2012",
month = "9",
day = "3",
doi = "10.1186/1471-2369-13-93",
language = "English",
volume = "13",
journal = "BMC Nephrology",
issn = "1471-2369",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Urinary N-acetyl - D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease

T2 - 1 year prospective cohort study

AU - Park, Hayne Cho

AU - Hwang, Jin Ho

AU - Kang, Ah Young

AU - Ro, Han

AU - Kim, Myung-Gyu

AU - An, Jung Nam

AU - In Park, Ji

AU - Kim, Seung Hyup

AU - Yang, Jaeseok

AU - Oh, Yun Kyu

AU - Oh, Kook Hwan

AU - Noh, Jung Woo

AU - Cheong, Hae Il

AU - Hwang, Young Hwan

AU - Ahn, Curie

PY - 2012/9/3

Y1 - 2012/9/3

N2 - Background: Renal failure is one of the most serious complications associated with autosomal dominant polycystic kidney disease (ADPKD). To date, early markers have failed to predict renal function deterioration at the early stages. This 1-year prospective study evaluated N-acetyl - D-glucosaminidase (NAG) as a new surrogate marker for renal function in ADPKD. Methods. A total of 270 patients were enrolled in the study, and we measured urinary NAG, 2-microglobulin, neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) prospectively for 1year to compare their predictive values for renal function. Results: Baseline urinary NAG/Cr was negatively correlated with estimated glomerular filtration rate (GFR) (r 2 =0.153, P<0.001) and positively correlated with total kidney volume (TKV) (r 2 =0.113, P<0.001). Among other biomarkers, urinary NAG/Cr better discriminated patients with decreased renal function from those with conserved renal function, showing the largest area under the curve (AUC 0.794). Immunohistochemical study revealed strong staining along the cyst-lining epithelial cells as well as the nearby compressed tubular epithelial cells. However, both single and repeated measurements of urinary NAG/Cr failed to predict renal function decline in 1year. Conclusions: Urinary NAG/Cr may be a useful surrogate marker for renal function in ADPKD patients.

AB - Background: Renal failure is one of the most serious complications associated with autosomal dominant polycystic kidney disease (ADPKD). To date, early markers have failed to predict renal function deterioration at the early stages. This 1-year prospective study evaluated N-acetyl - D-glucosaminidase (NAG) as a new surrogate marker for renal function in ADPKD. Methods. A total of 270 patients were enrolled in the study, and we measured urinary NAG, 2-microglobulin, neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) prospectively for 1year to compare their predictive values for renal function. Results: Baseline urinary NAG/Cr was negatively correlated with estimated glomerular filtration rate (GFR) (r 2 =0.153, P<0.001) and positively correlated with total kidney volume (TKV) (r 2 =0.113, P<0.001). Among other biomarkers, urinary NAG/Cr better discriminated patients with decreased renal function from those with conserved renal function, showing the largest area under the curve (AUC 0.794). Immunohistochemical study revealed strong staining along the cyst-lining epithelial cells as well as the nearby compressed tubular epithelial cells. However, both single and repeated measurements of urinary NAG/Cr failed to predict renal function decline in 1year. Conclusions: Urinary NAG/Cr may be a useful surrogate marker for renal function in ADPKD patients.

KW - Autosomal dominant polycystic kidney disease

KW - Biomarkers

KW - Renal function

UR - http://www.scopus.com/inward/record.url?scp=84865492308&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865492308&partnerID=8YFLogxK

U2 - 10.1186/1471-2369-13-93

DO - 10.1186/1471-2369-13-93

M3 - Article

C2 - 22935351

AN - SCOPUS:84865492308

VL - 13

JO - BMC Nephrology

JF - BMC Nephrology

SN - 1471-2369

IS - 1

M1 - 93

ER -