Urine neutrophil gelatinase-associated lipocalin

An independent predictor of adverse outcomes in acute kidney injury

Ha Na Yang, Chang Soo Boo, Myung-Gyu Kim, Sang Kyung Jo, Won Yong Cho, Hyoung Kyu Kim

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background: Several recent studies have shown that neutrophil gelatinase-associated lipocalin (NGAL) may be a promising biomarker for the early detection of acute kidney injury (AKI), but the role of NGAL in predicting adverse clinical outcomes has not been well addressed. The purpose of this study was to evaluate the usefulness of urine NGAL as outcome predictor in patients with AKI. Methods: This was a prospective cohort study enrolling hospitalized AKI patients. Patients were divided into four groups according to initial urine NGAL excretion quartiles. The primary clinical outcome variables were in-hospital mortality and renal function at 4 weeks. Results: Initial urine NGAL was identified as an independent predictor of in-hospital mortality and persistent loss of renal function. In the analysis of predictive performance of urine NGAL, the AUC was 0.882 and a cutoff value of 298.28 ng/ml predicted loss of renal function with 88.2% sensitivity and 81.0% specificity. Conclusion: This study could suggest that urine NGAL, a new early biomarker might also be served as a reliable clinical outcome predictor in AKI patients.

Original languageEnglish
Pages (from-to)501-509
Number of pages9
JournalAmerican Journal of Nephrology
Volume31
Issue number6
DOIs
Publication statusPublished - 2010 Jun 1

Fingerprint

Acute Kidney Injury
Urine
Hospital Mortality
Kidney
Biomarkers
Lipocalin-2
Area Under Curve
Cohort Studies
Prospective Studies
Sensitivity and Specificity

Keywords

  • Acute kidney injury
  • Prognosis
  • Urine neutrophil gelatinase-associated lipocalin

ASJC Scopus subject areas

  • Nephrology

Cite this

Urine neutrophil gelatinase-associated lipocalin : An independent predictor of adverse outcomes in acute kidney injury. / Yang, Ha Na; Boo, Chang Soo; Kim, Myung-Gyu; Jo, Sang Kyung; Cho, Won Yong; Kim, Hyoung Kyu.

In: American Journal of Nephrology, Vol. 31, No. 6, 01.06.2010, p. 501-509.

Research output: Contribution to journalArticle

@article{f256c0ae4c214e02bc5b4b3a729bf6e8,
title = "Urine neutrophil gelatinase-associated lipocalin: An independent predictor of adverse outcomes in acute kidney injury",
abstract = "Background: Several recent studies have shown that neutrophil gelatinase-associated lipocalin (NGAL) may be a promising biomarker for the early detection of acute kidney injury (AKI), but the role of NGAL in predicting adverse clinical outcomes has not been well addressed. The purpose of this study was to evaluate the usefulness of urine NGAL as outcome predictor in patients with AKI. Methods: This was a prospective cohort study enrolling hospitalized AKI patients. Patients were divided into four groups according to initial urine NGAL excretion quartiles. The primary clinical outcome variables were in-hospital mortality and renal function at 4 weeks. Results: Initial urine NGAL was identified as an independent predictor of in-hospital mortality and persistent loss of renal function. In the analysis of predictive performance of urine NGAL, the AUC was 0.882 and a cutoff value of 298.28 ng/ml predicted loss of renal function with 88.2{\%} sensitivity and 81.0{\%} specificity. Conclusion: This study could suggest that urine NGAL, a new early biomarker might also be served as a reliable clinical outcome predictor in AKI patients.",
keywords = "Acute kidney injury, Prognosis, Urine neutrophil gelatinase-associated lipocalin",
author = "Yang, {Ha Na} and Boo, {Chang Soo} and Myung-Gyu Kim and Jo, {Sang Kyung} and Cho, {Won Yong} and Kim, {Hyoung Kyu}",
year = "2010",
month = "6",
day = "1",
doi = "10.1159/000309841",
language = "English",
volume = "31",
pages = "501--509",
journal = "American Journal of Nephrology",
issn = "0250-8095",
publisher = "S. Karger AG",
number = "6",

}

TY - JOUR

T1 - Urine neutrophil gelatinase-associated lipocalin

T2 - An independent predictor of adverse outcomes in acute kidney injury

AU - Yang, Ha Na

AU - Boo, Chang Soo

AU - Kim, Myung-Gyu

AU - Jo, Sang Kyung

AU - Cho, Won Yong

AU - Kim, Hyoung Kyu

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Background: Several recent studies have shown that neutrophil gelatinase-associated lipocalin (NGAL) may be a promising biomarker for the early detection of acute kidney injury (AKI), but the role of NGAL in predicting adverse clinical outcomes has not been well addressed. The purpose of this study was to evaluate the usefulness of urine NGAL as outcome predictor in patients with AKI. Methods: This was a prospective cohort study enrolling hospitalized AKI patients. Patients were divided into four groups according to initial urine NGAL excretion quartiles. The primary clinical outcome variables were in-hospital mortality and renal function at 4 weeks. Results: Initial urine NGAL was identified as an independent predictor of in-hospital mortality and persistent loss of renal function. In the analysis of predictive performance of urine NGAL, the AUC was 0.882 and a cutoff value of 298.28 ng/ml predicted loss of renal function with 88.2% sensitivity and 81.0% specificity. Conclusion: This study could suggest that urine NGAL, a new early biomarker might also be served as a reliable clinical outcome predictor in AKI patients.

AB - Background: Several recent studies have shown that neutrophil gelatinase-associated lipocalin (NGAL) may be a promising biomarker for the early detection of acute kidney injury (AKI), but the role of NGAL in predicting adverse clinical outcomes has not been well addressed. The purpose of this study was to evaluate the usefulness of urine NGAL as outcome predictor in patients with AKI. Methods: This was a prospective cohort study enrolling hospitalized AKI patients. Patients were divided into four groups according to initial urine NGAL excretion quartiles. The primary clinical outcome variables were in-hospital mortality and renal function at 4 weeks. Results: Initial urine NGAL was identified as an independent predictor of in-hospital mortality and persistent loss of renal function. In the analysis of predictive performance of urine NGAL, the AUC was 0.882 and a cutoff value of 298.28 ng/ml predicted loss of renal function with 88.2% sensitivity and 81.0% specificity. Conclusion: This study could suggest that urine NGAL, a new early biomarker might also be served as a reliable clinical outcome predictor in AKI patients.

KW - Acute kidney injury

KW - Prognosis

KW - Urine neutrophil gelatinase-associated lipocalin

UR - http://www.scopus.com/inward/record.url?scp=77951960763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951960763&partnerID=8YFLogxK

U2 - 10.1159/000309841

DO - 10.1159/000309841

M3 - Article

VL - 31

SP - 501

EP - 509

JO - American Journal of Nephrology

JF - American Journal of Nephrology

SN - 0250-8095

IS - 6

ER -