Ursodeoxycholic acid inhibits liver X receptor α-mediated hepatic lipogenesis via induction of the nuclear corepressor smile

Ji Min Lee, Gil Tae Gang, Don Kyu Kim, Yong Deuk Kim, Seung-Hoi Koo, Chul Ho Lee, Hueng Sik Choi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Small heterodimer partner interacting leucine zipper protein (SMILE) is a nuclear corepressor of the nuclear receptor family. Results: Ursodeoxycholic acid (UDCA) increases SMILE gene expression, which contributes to inhibiting liver X receptor α (LXRα)-mediated hepatic lipogenesis. Conclusion: UDCA-induced smile inhibits LXRα-mediated hepatic lipogenic gene expression.

Original languageEnglish
Pages (from-to)1079-1091
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number2
DOIs
Publication statusPublished - 2014 Jan 10

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Ursodeoxycholic Acid
Co-Repressor Proteins
Lipogenesis
Gene expression
Liver
Gene Expression
Leucine Zippers
Nuclear Family
Proteins
Liver X Receptors

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Ursodeoxycholic acid inhibits liver X receptor α-mediated hepatic lipogenesis via induction of the nuclear corepressor smile. / Lee, Ji Min; Gang, Gil Tae; Kim, Don Kyu; Kim, Yong Deuk; Koo, Seung-Hoi; Lee, Chul Ho; Choi, Hueng Sik.

In: Journal of Biological Chemistry, Vol. 289, No. 2, 10.01.2014, p. 1079-1091.

Research output: Contribution to journalArticle

Lee, Ji Min ; Gang, Gil Tae ; Kim, Don Kyu ; Kim, Yong Deuk ; Koo, Seung-Hoi ; Lee, Chul Ho ; Choi, Hueng Sik. / Ursodeoxycholic acid inhibits liver X receptor α-mediated hepatic lipogenesis via induction of the nuclear corepressor smile. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 2. pp. 1079-1091.
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