Ursodeoxycholic acid inhibits liver X receptor α-mediated hepatic lipogenesis via induction of the nuclear corepressor smile

Ji Min Lee, Gil Tae Gang, Don Kyu Kim, Yong Deuk Kim, Seung Hoi Koo, Chul Ho Lee, Hueng Sik Choi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Small heterodimer partner interacting leucine zipper protein (SMILE) is a nuclear corepressor of the nuclear receptor family. Results: Ursodeoxycholic acid (UDCA) increases SMILE gene expression, which contributes to inhibiting liver X receptor α (LXRα)-mediated hepatic lipogenesis. Conclusion: UDCA-induced smile inhibits LXRα-mediated hepatic lipogenic gene expression.

Original languageEnglish
Pages (from-to)1079-1091
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number2
DOIs
Publication statusPublished - 2014 Jan 10

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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