Use of a parallel artificial membrane system to evaluate passive absorption and elimination in small fish

Jung Hwan Kwon, Lynn E. Katz, Howard M. Liljestrand

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A parallel artificial lipid membrane system was developed to mimic passive mass transfer of hydrophobic organic chemicals in fish. In this physical model system, a membrane filter-supported lipid bilayer separates two aqueous phases that represent the external and internal aqueous environments of fish. To predict bioconcentration kinetics in small fish with this system, literature absorption and elimination rates were analyzed with an allometric diffusion model to quantify the mass transfer resistances in the aqueous and lipid phases of fish. The effect of the aqueous phase mass transfer resistance was controlled by adjusting stirring intensity to mimic bioconcentration rates in small fish. Twenty-three simple aromatic hydrocarbons were chosen as model compounds for purposes of evaluation. For most of the selected chemicals, literature absorption/elimination rates fall into the range predicted from measured membrane permeabilities and elimination rates of the selected chemicals determined by the diffusion model system.

Original languageEnglish
Pages (from-to)3083-3092
Number of pages10
JournalEnvironmental Toxicology and Chemistry
Volume25
Issue number12
DOIs
Publication statusPublished - 2006 Dec 1

Keywords

  • Artificial membranes
  • Bioconcentration
  • Diffusion
  • Fish

ASJC Scopus subject areas

  • Environmental Chemistry
  • Health, Toxicology and Mutagenesis

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