Use of imaging to predict complete response of colorectal liver metastases after chemotherapy: MR imaging versus CT imaging

Min Jung Park, Nurhee Hong, Kyunghwa Han, Min Ju Kim, Yoon Jin Lee, Yang Shin Park, Sung Eun Rha, Sumi Park, Won Jae Lee, Seong Ho Park, Chang-Hee Lee, Chung Mo Nam, Chansik An, Hye Jin Kim, Honsoul Kim, Mi Suk Park

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Abstract

Purpose: To compare the diagnostic performances of contrast agent-enhanced computed tomography (CT) and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced liver magnetic resonance (MR) imaging (referred to as EOB MR imaging) in the evaluation of disappearing colorectal liver metastases (CRLMs) after chemotherapy. Materials and Methods: The eight institutional review boards approved this retrospective study and waived the requirement for informed consent. On the basis of retrospective searches in eight hospitals, 87 patients with 393 CRLMs, each patient with one or more CRLM that later disappeared on contrastenhanced CT scans after chemotherapy, and subsequently underwent surgery for the CRLMs, were enrolled. The anonymized imaging data and case report forms were sent to the central review system and independently reviewed by four radiologists. All anonymized data were randomly allocated into two groups (groups A and B), which were read by two independent readers. True absence of tumor was defined as pathologic absence of tumor for resected lesions and no in situ recurrence within 1 year after surgery for lesions left unresected at each 3-month follow-up contrast-enhanced CT. Positive predictive values for absence of tumor and for residual tumor on contrast-enhanced CT and EOB MR images were compared by using a generalized estimating equation. Results: Among 393 CRLMs, the positive predictive value for absence of tumor on EOB MR images (78.0%; 95% confidence interval [CI]: 63.68%, 87.74%) was significantly higher than that on contrast-enhanced CT scans (35.2%; 95% CI: 25.11%, 46.79%; P , .001). The positive predictive value for residual tumor on CT scans (86.0%; 95% CI: 78.61%, 91.16%) was higher than that on EOB MR images (83.8%; 95% CI: 77.50%, 88.67%) without statistical significance (P = .330). Conclusion: EOB MR imaging was superior to contrast-enhanced CT imaging for assessment of disappearing CRLMs after chemotherapy.

Original languageEnglish
Pages (from-to)423-431
Number of pages9
JournalRadiology
Volume284
Issue number2
DOIs
Publication statusPublished - 2017 Aug 1

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Tomography
Magnetic Resonance Imaging
Neoplasm Metastasis
Drug Therapy
Liver
Confidence Intervals
Magnetic Resonance Spectroscopy
Residual Neoplasm
Neoplasms
Pentetic Acid
Colorectal Surgery
Research Ethics Committees
Gadolinium
Informed Consent
Contrast Media
Retrospective Studies
Recurrence

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Use of imaging to predict complete response of colorectal liver metastases after chemotherapy : MR imaging versus CT imaging. / Park, Min Jung; Hong, Nurhee; Han, Kyunghwa; Kim, Min Ju; Lee, Yoon Jin; Park, Yang Shin; Rha, Sung Eun; Park, Sumi; Lee, Won Jae; Park, Seong Ho; Lee, Chang-Hee; Nam, Chung Mo; An, Chansik; Kim, Hye Jin; Kim, Honsoul; Park, Mi Suk.

In: Radiology, Vol. 284, No. 2, 01.08.2017, p. 423-431.

Research output: Contribution to journalArticle

Park, MJ, Hong, N, Han, K, Kim, MJ, Lee, YJ, Park, YS, Rha, SE, Park, S, Lee, WJ, Park, SH, Lee, C-H, Nam, CM, An, C, Kim, HJ, Kim, H & Park, MS 2017, 'Use of imaging to predict complete response of colorectal liver metastases after chemotherapy: MR imaging versus CT imaging', Radiology, vol. 284, no. 2, pp. 423-431. https://doi.org/10.1148/radiol.2017161619
Park, Min Jung ; Hong, Nurhee ; Han, Kyunghwa ; Kim, Min Ju ; Lee, Yoon Jin ; Park, Yang Shin ; Rha, Sung Eun ; Park, Sumi ; Lee, Won Jae ; Park, Seong Ho ; Lee, Chang-Hee ; Nam, Chung Mo ; An, Chansik ; Kim, Hye Jin ; Kim, Honsoul ; Park, Mi Suk. / Use of imaging to predict complete response of colorectal liver metastases after chemotherapy : MR imaging versus CT imaging. In: Radiology. 2017 ; Vol. 284, No. 2. pp. 423-431.
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abstract = "Purpose: To compare the diagnostic performances of contrast agent-enhanced computed tomography (CT) and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced liver magnetic resonance (MR) imaging (referred to as EOB MR imaging) in the evaluation of disappearing colorectal liver metastases (CRLMs) after chemotherapy. Materials and Methods: The eight institutional review boards approved this retrospective study and waived the requirement for informed consent. On the basis of retrospective searches in eight hospitals, 87 patients with 393 CRLMs, each patient with one or more CRLM that later disappeared on contrastenhanced CT scans after chemotherapy, and subsequently underwent surgery for the CRLMs, were enrolled. The anonymized imaging data and case report forms were sent to the central review system and independently reviewed by four radiologists. All anonymized data were randomly allocated into two groups (groups A and B), which were read by two independent readers. True absence of tumor was defined as pathologic absence of tumor for resected lesions and no in situ recurrence within 1 year after surgery for lesions left unresected at each 3-month follow-up contrast-enhanced CT. Positive predictive values for absence of tumor and for residual tumor on contrast-enhanced CT and EOB MR images were compared by using a generalized estimating equation. Results: Among 393 CRLMs, the positive predictive value for absence of tumor on EOB MR images (78.0{\%}; 95{\%} confidence interval [CI]: 63.68{\%}, 87.74{\%}) was significantly higher than that on contrast-enhanced CT scans (35.2{\%}; 95{\%} CI: 25.11{\%}, 46.79{\%}; P , .001). The positive predictive value for residual tumor on CT scans (86.0{\%}; 95{\%} CI: 78.61{\%}, 91.16{\%}) was higher than that on EOB MR images (83.8{\%}; 95{\%} CI: 77.50{\%}, 88.67{\%}) without statistical significance (P = .330). Conclusion: EOB MR imaging was superior to contrast-enhanced CT imaging for assessment of disappearing CRLMs after chemotherapy.",
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T1 - Use of imaging to predict complete response of colorectal liver metastases after chemotherapy

T2 - MR imaging versus CT imaging

AU - Park, Min Jung

AU - Hong, Nurhee

AU - Han, Kyunghwa

AU - Kim, Min Ju

AU - Lee, Yoon Jin

AU - Park, Yang Shin

AU - Rha, Sung Eun

AU - Park, Sumi

AU - Lee, Won Jae

AU - Park, Seong Ho

AU - Lee, Chang-Hee

AU - Nam, Chung Mo

AU - An, Chansik

AU - Kim, Hye Jin

AU - Kim, Honsoul

AU - Park, Mi Suk

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Purpose: To compare the diagnostic performances of contrast agent-enhanced computed tomography (CT) and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced liver magnetic resonance (MR) imaging (referred to as EOB MR imaging) in the evaluation of disappearing colorectal liver metastases (CRLMs) after chemotherapy. Materials and Methods: The eight institutional review boards approved this retrospective study and waived the requirement for informed consent. On the basis of retrospective searches in eight hospitals, 87 patients with 393 CRLMs, each patient with one or more CRLM that later disappeared on contrastenhanced CT scans after chemotherapy, and subsequently underwent surgery for the CRLMs, were enrolled. The anonymized imaging data and case report forms were sent to the central review system and independently reviewed by four radiologists. All anonymized data were randomly allocated into two groups (groups A and B), which were read by two independent readers. True absence of tumor was defined as pathologic absence of tumor for resected lesions and no in situ recurrence within 1 year after surgery for lesions left unresected at each 3-month follow-up contrast-enhanced CT. Positive predictive values for absence of tumor and for residual tumor on contrast-enhanced CT and EOB MR images were compared by using a generalized estimating equation. Results: Among 393 CRLMs, the positive predictive value for absence of tumor on EOB MR images (78.0%; 95% confidence interval [CI]: 63.68%, 87.74%) was significantly higher than that on contrast-enhanced CT scans (35.2%; 95% CI: 25.11%, 46.79%; P , .001). The positive predictive value for residual tumor on CT scans (86.0%; 95% CI: 78.61%, 91.16%) was higher than that on EOB MR images (83.8%; 95% CI: 77.50%, 88.67%) without statistical significance (P = .330). Conclusion: EOB MR imaging was superior to contrast-enhanced CT imaging for assessment of disappearing CRLMs after chemotherapy.

AB - Purpose: To compare the diagnostic performances of contrast agent-enhanced computed tomography (CT) and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced liver magnetic resonance (MR) imaging (referred to as EOB MR imaging) in the evaluation of disappearing colorectal liver metastases (CRLMs) after chemotherapy. Materials and Methods: The eight institutional review boards approved this retrospective study and waived the requirement for informed consent. On the basis of retrospective searches in eight hospitals, 87 patients with 393 CRLMs, each patient with one or more CRLM that later disappeared on contrastenhanced CT scans after chemotherapy, and subsequently underwent surgery for the CRLMs, were enrolled. The anonymized imaging data and case report forms were sent to the central review system and independently reviewed by four radiologists. All anonymized data were randomly allocated into two groups (groups A and B), which were read by two independent readers. True absence of tumor was defined as pathologic absence of tumor for resected lesions and no in situ recurrence within 1 year after surgery for lesions left unresected at each 3-month follow-up contrast-enhanced CT. Positive predictive values for absence of tumor and for residual tumor on contrast-enhanced CT and EOB MR images were compared by using a generalized estimating equation. Results: Among 393 CRLMs, the positive predictive value for absence of tumor on EOB MR images (78.0%; 95% confidence interval [CI]: 63.68%, 87.74%) was significantly higher than that on contrast-enhanced CT scans (35.2%; 95% CI: 25.11%, 46.79%; P , .001). The positive predictive value for residual tumor on CT scans (86.0%; 95% CI: 78.61%, 91.16%) was higher than that on EOB MR images (83.8%; 95% CI: 77.50%, 88.67%) without statistical significance (P = .330). Conclusion: EOB MR imaging was superior to contrast-enhanced CT imaging for assessment of disappearing CRLMs after chemotherapy.

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