Usefulness of fecal immunochemical test and fecal calprotectin for detection of active ulcerative colitis

Dong Ju Kim, Yoon Mi Jeoun, Dong won Lee, Ja Seol Koo, Sang Woo Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background/Aims: Ulcerative colitis undergoes periods of exacerbation and remission. Fecal calprotectin levels increase with gut inflammation and correlate with endoscopic disease activity in ulcerative colitis. Intestinal blood loss and fecal immunochemical test levels also correlate with endoscopic disease activity. This study statistically evaluated the usefulness of fecal calprotectin, fecal immunochemical test, and C-reactive protein (CRP) as markers of disease activity. Methods: A total 106 ulcerative colitis patients who underwent endoscopy and fecal calprotectin, fecal immunochemical test, and CRP testing, from March 2015 to August 2016, were retrospectively reviewed. Disease activity was assessed using a partial Mayo score and Mayo endoscopic score. The ability of fecal and serologic tests to reflect endoscopic disease severity was statistically evaluated. Results: Among 106 patients, 68 underwent endoscopy and stool study within 2 weeks. In patients with mild to severe activity, fecal immunochemical test and fecal calprotectin were superior to CRP at Mayo endoscopic score detection rate. The area under the curves of fecal immunochemical test and fecal calprotectin for the detection of Mayo endoscopic score =1 were 0.956 and 0.942, respectively, and were superior to that of CRP (0.756). At Mayo endoscopic score, the effects of combination of fecal immunochemical test and CRP or fecal calprotectin and CRP were found to be higher than those of the independent fecal immunochemical test or fecal calprotectin. Conclusions: Fecal immunochemical test and fecal calprotectin can effectively detect active ulcerative colitis better than remission. As these markers reflect the status of mucosal inflammation, they may reduce the requirement for invasive endoscopic examination.

Original languageEnglish
Pages (from-to)563-570
Number of pages8
JournalIntestinal Research
Volume16
Issue number4
DOIs
Publication statusPublished - 2018 Oct 1

Fingerprint

Leukocyte L1 Antigen Complex
Ulcerative Colitis
C-Reactive Protein
Endoscopy
Inflammation
Serologic Tests
Area Under Curve

Keywords

  • C-reactive protein
  • Colitis
  • Fecal calprotectin
  • Fecal immunochemical test
  • Ulcerative

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Usefulness of fecal immunochemical test and fecal calprotectin for detection of active ulcerative colitis. / Kim, Dong Ju; Jeoun, Yoon Mi; Lee, Dong won; Koo, Ja Seol; Lee, Sang Woo.

In: Intestinal Research, Vol. 16, No. 4, 01.10.2018, p. 563-570.

Research output: Contribution to journalArticle

@article{d3df830f6e7e47afb172096e37130af3,
title = "Usefulness of fecal immunochemical test and fecal calprotectin for detection of active ulcerative colitis",
abstract = "Background/Aims: Ulcerative colitis undergoes periods of exacerbation and remission. Fecal calprotectin levels increase with gut inflammation and correlate with endoscopic disease activity in ulcerative colitis. Intestinal blood loss and fecal immunochemical test levels also correlate with endoscopic disease activity. This study statistically evaluated the usefulness of fecal calprotectin, fecal immunochemical test, and C-reactive protein (CRP) as markers of disease activity. Methods: A total 106 ulcerative colitis patients who underwent endoscopy and fecal calprotectin, fecal immunochemical test, and CRP testing, from March 2015 to August 2016, were retrospectively reviewed. Disease activity was assessed using a partial Mayo score and Mayo endoscopic score. The ability of fecal and serologic tests to reflect endoscopic disease severity was statistically evaluated. Results: Among 106 patients, 68 underwent endoscopy and stool study within 2 weeks. In patients with mild to severe activity, fecal immunochemical test and fecal calprotectin were superior to CRP at Mayo endoscopic score detection rate. The area under the curves of fecal immunochemical test and fecal calprotectin for the detection of Mayo endoscopic score =1 were 0.956 and 0.942, respectively, and were superior to that of CRP (0.756). At Mayo endoscopic score, the effects of combination of fecal immunochemical test and CRP or fecal calprotectin and CRP were found to be higher than those of the independent fecal immunochemical test or fecal calprotectin. Conclusions: Fecal immunochemical test and fecal calprotectin can effectively detect active ulcerative colitis better than remission. As these markers reflect the status of mucosal inflammation, they may reduce the requirement for invasive endoscopic examination.",
keywords = "C-reactive protein, Colitis, Fecal calprotectin, Fecal immunochemical test, Ulcerative",
author = "Kim, {Dong Ju} and Jeoun, {Yoon Mi} and Lee, {Dong won} and Koo, {Ja Seol} and Lee, {Sang Woo}",
year = "2018",
month = "10",
day = "1",
doi = "10.5217/ir.2018.00020",
language = "English",
volume = "16",
pages = "563--570",
journal = "Intestinal Research",
issn = "1598-9100",
publisher = "Korean Association for the Study of Intestinal Diseases",
number = "4",

}

TY - JOUR

T1 - Usefulness of fecal immunochemical test and fecal calprotectin for detection of active ulcerative colitis

AU - Kim, Dong Ju

AU - Jeoun, Yoon Mi

AU - Lee, Dong won

AU - Koo, Ja Seol

AU - Lee, Sang Woo

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background/Aims: Ulcerative colitis undergoes periods of exacerbation and remission. Fecal calprotectin levels increase with gut inflammation and correlate with endoscopic disease activity in ulcerative colitis. Intestinal blood loss and fecal immunochemical test levels also correlate with endoscopic disease activity. This study statistically evaluated the usefulness of fecal calprotectin, fecal immunochemical test, and C-reactive protein (CRP) as markers of disease activity. Methods: A total 106 ulcerative colitis patients who underwent endoscopy and fecal calprotectin, fecal immunochemical test, and CRP testing, from March 2015 to August 2016, were retrospectively reviewed. Disease activity was assessed using a partial Mayo score and Mayo endoscopic score. The ability of fecal and serologic tests to reflect endoscopic disease severity was statistically evaluated. Results: Among 106 patients, 68 underwent endoscopy and stool study within 2 weeks. In patients with mild to severe activity, fecal immunochemical test and fecal calprotectin were superior to CRP at Mayo endoscopic score detection rate. The area under the curves of fecal immunochemical test and fecal calprotectin for the detection of Mayo endoscopic score =1 were 0.956 and 0.942, respectively, and were superior to that of CRP (0.756). At Mayo endoscopic score, the effects of combination of fecal immunochemical test and CRP or fecal calprotectin and CRP were found to be higher than those of the independent fecal immunochemical test or fecal calprotectin. Conclusions: Fecal immunochemical test and fecal calprotectin can effectively detect active ulcerative colitis better than remission. As these markers reflect the status of mucosal inflammation, they may reduce the requirement for invasive endoscopic examination.

AB - Background/Aims: Ulcerative colitis undergoes periods of exacerbation and remission. Fecal calprotectin levels increase with gut inflammation and correlate with endoscopic disease activity in ulcerative colitis. Intestinal blood loss and fecal immunochemical test levels also correlate with endoscopic disease activity. This study statistically evaluated the usefulness of fecal calprotectin, fecal immunochemical test, and C-reactive protein (CRP) as markers of disease activity. Methods: A total 106 ulcerative colitis patients who underwent endoscopy and fecal calprotectin, fecal immunochemical test, and CRP testing, from March 2015 to August 2016, were retrospectively reviewed. Disease activity was assessed using a partial Mayo score and Mayo endoscopic score. The ability of fecal and serologic tests to reflect endoscopic disease severity was statistically evaluated. Results: Among 106 patients, 68 underwent endoscopy and stool study within 2 weeks. In patients with mild to severe activity, fecal immunochemical test and fecal calprotectin were superior to CRP at Mayo endoscopic score detection rate. The area under the curves of fecal immunochemical test and fecal calprotectin for the detection of Mayo endoscopic score =1 were 0.956 and 0.942, respectively, and were superior to that of CRP (0.756). At Mayo endoscopic score, the effects of combination of fecal immunochemical test and CRP or fecal calprotectin and CRP were found to be higher than those of the independent fecal immunochemical test or fecal calprotectin. Conclusions: Fecal immunochemical test and fecal calprotectin can effectively detect active ulcerative colitis better than remission. As these markers reflect the status of mucosal inflammation, they may reduce the requirement for invasive endoscopic examination.

KW - C-reactive protein

KW - Colitis

KW - Fecal calprotectin

KW - Fecal immunochemical test

KW - Ulcerative

UR - http://www.scopus.com/inward/record.url?scp=85056514999&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056514999&partnerID=8YFLogxK

U2 - 10.5217/ir.2018.00020

DO - 10.5217/ir.2018.00020

M3 - Article

AN - SCOPUS:85056514999

VL - 16

SP - 563

EP - 570

JO - Intestinal Research

JF - Intestinal Research

SN - 1598-9100

IS - 4

ER -