Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas

Baek-Hui Kim, Yoon sung Bae, Se Hoon Kim, Hyeong jae Jeong, Soon Won Hong, Sun Och Yoon

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Pulmonary sclerosing hemangioma (PSH) is an uncommon lung neoplasm with a clinical outcome that is generally benign. However, differentiating PSH from pulmonary carcinoma is sometimes difficult as both lesions share similar histopathologic and immunohistochemical features. In this study, we investigated the usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of PSH. We compared the staining pattern for Ki-67 (MIB-1) in 29 cases of typical PSH and 79 cases of pulmonary non-small cell carcinoma (NSCLC) using an immunohistochemical method on formalin-fixed paraffin-embedded tissues. In all studied PSH cases, we noted cell membrane and cytoplasmic staining for Ki-67 (MIB-1), but this was not observed in any of the NSCLC cases. The Ki-67 proliferation index was lower in PSH than in the NSCLC cases (mean, 1.1% vs mean, 5.5%; p < 0.001). These findings suggest that cell membrane and cytoplasmic staining for Ki-67 (MIB-1), as well as the Ki-67 proliferation index, may be useful for distinguishing PSH from pulmonary carcinoma. APMIS

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalAPMIS
Volume121
Issue number2
DOIs
Publication statusPublished - 2013 Feb 1

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Pulmonary Sclerosing Hemangioma
Carcinoma
Staining and Labeling
Cell Membrane
Paraffin
Formaldehyde
Lung Neoplasms

Keywords

  • Immunohistochemistry
  • Ki-67 antigen
  • MIB-1 antibody
  • Pulmonary sclerosing hemangioma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Microbiology (medical)

Cite this

Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas. / Kim, Baek-Hui; Bae, Yoon sung; Kim, Se Hoon; Jeong, Hyeong jae; Hong, Soon Won; Yoon, Sun Och.

In: APMIS, Vol. 121, No. 2, 01.02.2013, p. 105-110.

Research output: Contribution to journalArticle

Kim, Baek-Hui ; Bae, Yoon sung ; Kim, Se Hoon ; Jeong, Hyeong jae ; Hong, Soon Won ; Yoon, Sun Och. / Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas. In: APMIS. 2013 ; Vol. 121, No. 2. pp. 105-110.
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