Usefulness of N-terminal pro-B-type natriuretic peptide in patients admitted to the intensive care unit

A multicenter prospective observational study

Chin K. Rhee, So Y. Lim, Shin O. Koh, Won Il Choi, Young Joo Lee, Gyu R. Chon, Je Hyeong Kim, Jae Y. Kim, Jaemin Lim, Sunghoon Park, Ho C. Kim, Jin H. Lee, Ji H. Lee, Jisook Park, Younsuck Koh, Gee Y. Suh, Seok C. Kim, Kyeongman Jeon, Chi Min Park, Chae Man Lim & 7 others Sang Bum Hong, Jin Won Huh, Suk Kyung Hong, Sungwon Na, Kwang Joo Park, Chan Kwon Park, Jae Hwa Cho

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The role of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) as a prognostic factor in patients admitted to the intensive care unit (ICU) is not yet fully established. We aimed to determine whether NT-pro-BNP is predictive of ICU mortality in a multicenter cohort of critically ill patients. Methods: A total of 1440 patients admitted to 22 ICUs (medical, 14; surgical, six; multidisciplinary, two) in 15 tertiary or university-affiliated hospitals between July 2010 and January 2011 were assessed. Patient data, including NT-pro-BNP levels and Simplified Acute Physiology Score (SAPS) 3 scores, were recorded prospectively in a web-based database. Results: The median age was 64 years (range, 53-73 years), and 906 (62.9%) patients were male. The median NT-pro-BNP level was 341 pg/mL (104-1,637 pg/mL), and the median SAPS 3 score was 57 (range, 47-69). The ICU mortality rate was 18.9%, and hospital mortality was 24.5%. Hospital survivors showed significantly lower NT-pro-BNP values than nonsurvivors (245 pg/mL [range, 82-1,053 pg/mL] vs. 875 pg/mL [241-5,000 pg/mL], respectively; p < 0.001). In prediction of hospital mortality, the area under the curve (AUC) for NT-pro-BNP was 0.67 (95% confidence interval [CI], 0.64-0.70) and SAPS 3 score was 0.83 (95% CI, 0.81-0.85). AUC increment by adding NT-pro-BNP is minimal and likely no different to SAPS 3 alone. Conclusions: The NT-pro-BNP level was more elevated in nonsurvivors in a multicenter cohort of critically ill patients. However, there was little additional prognostic power when adding NT-pro-BNP to SAPS 3 score.

Original languageEnglish
Article number16
JournalBMC Anesthesiology
Volume14
DOIs
Publication statusPublished - 2014 Mar 10

Fingerprint

Brain Natriuretic Peptide
Observational Studies
Intensive Care Units
Prospective Studies
Hospital Mortality
Critical Illness
Area Under Curve
Confidence Intervals
Mortality
Survivors
Simplified Acute Physiology Score
Databases

Keywords

  • Critical care
  • Intensive care unit
  • N-terminal pro-B-type natriuretic peptide
  • Prognosis

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Usefulness of N-terminal pro-B-type natriuretic peptide in patients admitted to the intensive care unit : A multicenter prospective observational study. / Rhee, Chin K.; Lim, So Y.; Koh, Shin O.; Choi, Won Il; Lee, Young Joo; Chon, Gyu R.; Kim, Je Hyeong; Kim, Jae Y.; Lim, Jaemin; Park, Sunghoon; Kim, Ho C.; Lee, Jin H.; Lee, Ji H.; Park, Jisook; Koh, Younsuck; Suh, Gee Y.; Kim, Seok C.; Jeon, Kyeongman; Park, Chi Min; Lim, Chae Man; Hong, Sang Bum; Huh, Jin Won; Hong, Suk Kyung; Na, Sungwon; Park, Kwang Joo; Park, Chan Kwon; Cho, Jae Hwa.

In: BMC Anesthesiology, Vol. 14, 16, 10.03.2014.

Research output: Contribution to journalArticle

Rhee, CK, Lim, SY, Koh, SO, Choi, WI, Lee, YJ, Chon, GR, Kim, JH, Kim, JY, Lim, J, Park, S, Kim, HC, Lee, JH, Lee, JH, Park, J, Koh, Y, Suh, GY, Kim, SC, Jeon, K, Park, CM, Lim, CM, Hong, SB, Huh, JW, Hong, SK, Na, S, Park, KJ, Park, CK & Cho, JH 2014, 'Usefulness of N-terminal pro-B-type natriuretic peptide in patients admitted to the intensive care unit: A multicenter prospective observational study', BMC Anesthesiology, vol. 14, 16. https://doi.org/10.1186/1471-2253-14-16
Rhee, Chin K. ; Lim, So Y. ; Koh, Shin O. ; Choi, Won Il ; Lee, Young Joo ; Chon, Gyu R. ; Kim, Je Hyeong ; Kim, Jae Y. ; Lim, Jaemin ; Park, Sunghoon ; Kim, Ho C. ; Lee, Jin H. ; Lee, Ji H. ; Park, Jisook ; Koh, Younsuck ; Suh, Gee Y. ; Kim, Seok C. ; Jeon, Kyeongman ; Park, Chi Min ; Lim, Chae Man ; Hong, Sang Bum ; Huh, Jin Won ; Hong, Suk Kyung ; Na, Sungwon ; Park, Kwang Joo ; Park, Chan Kwon ; Cho, Jae Hwa. / Usefulness of N-terminal pro-B-type natriuretic peptide in patients admitted to the intensive care unit : A multicenter prospective observational study. In: BMC Anesthesiology. 2014 ; Vol. 14.
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abstract = "Background: The role of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) as a prognostic factor in patients admitted to the intensive care unit (ICU) is not yet fully established. We aimed to determine whether NT-pro-BNP is predictive of ICU mortality in a multicenter cohort of critically ill patients. Methods: A total of 1440 patients admitted to 22 ICUs (medical, 14; surgical, six; multidisciplinary, two) in 15 tertiary or university-affiliated hospitals between July 2010 and January 2011 were assessed. Patient data, including NT-pro-BNP levels and Simplified Acute Physiology Score (SAPS) 3 scores, were recorded prospectively in a web-based database. Results: The median age was 64 years (range, 53-73 years), and 906 (62.9{\%}) patients were male. The median NT-pro-BNP level was 341 pg/mL (104-1,637 pg/mL), and the median SAPS 3 score was 57 (range, 47-69). The ICU mortality rate was 18.9{\%}, and hospital mortality was 24.5{\%}. Hospital survivors showed significantly lower NT-pro-BNP values than nonsurvivors (245 pg/mL [range, 82-1,053 pg/mL] vs. 875 pg/mL [241-5,000 pg/mL], respectively; p < 0.001). In prediction of hospital mortality, the area under the curve (AUC) for NT-pro-BNP was 0.67 (95{\%} confidence interval [CI], 0.64-0.70) and SAPS 3 score was 0.83 (95{\%} CI, 0.81-0.85). AUC increment by adding NT-pro-BNP is minimal and likely no different to SAPS 3 alone. Conclusions: The NT-pro-BNP level was more elevated in nonsurvivors in a multicenter cohort of critically ill patients. However, there was little additional prognostic power when adding NT-pro-BNP to SAPS 3 score.",
keywords = "Critical care, Intensive care unit, N-terminal pro-B-type natriuretic peptide, Prognosis",
author = "Rhee, {Chin K.} and Lim, {So Y.} and Koh, {Shin O.} and Choi, {Won Il} and Lee, {Young Joo} and Chon, {Gyu R.} and Kim, {Je Hyeong} and Kim, {Jae Y.} and Jaemin Lim and Sunghoon Park and Kim, {Ho C.} and Lee, {Jin H.} and Lee, {Ji H.} and Jisook Park and Younsuck Koh and Suh, {Gee Y.} and Kim, {Seok C.} and Kyeongman Jeon and Park, {Chi Min} and Lim, {Chae Man} and Hong, {Sang Bum} and Huh, {Jin Won} and Hong, {Suk Kyung} and Sungwon Na and Park, {Kwang Joo} and Park, {Chan Kwon} and Cho, {Jae Hwa}",
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TY - JOUR

T1 - Usefulness of N-terminal pro-B-type natriuretic peptide in patients admitted to the intensive care unit

T2 - A multicenter prospective observational study

AU - Rhee, Chin K.

AU - Lim, So Y.

AU - Koh, Shin O.

AU - Choi, Won Il

AU - Lee, Young Joo

AU - Chon, Gyu R.

AU - Kim, Je Hyeong

AU - Kim, Jae Y.

AU - Lim, Jaemin

AU - Park, Sunghoon

AU - Kim, Ho C.

AU - Lee, Jin H.

AU - Lee, Ji H.

AU - Park, Jisook

AU - Koh, Younsuck

AU - Suh, Gee Y.

AU - Kim, Seok C.

AU - Jeon, Kyeongman

AU - Park, Chi Min

AU - Lim, Chae Man

AU - Hong, Sang Bum

AU - Huh, Jin Won

AU - Hong, Suk Kyung

AU - Na, Sungwon

AU - Park, Kwang Joo

AU - Park, Chan Kwon

AU - Cho, Jae Hwa

PY - 2014/3/10

Y1 - 2014/3/10

N2 - Background: The role of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) as a prognostic factor in patients admitted to the intensive care unit (ICU) is not yet fully established. We aimed to determine whether NT-pro-BNP is predictive of ICU mortality in a multicenter cohort of critically ill patients. Methods: A total of 1440 patients admitted to 22 ICUs (medical, 14; surgical, six; multidisciplinary, two) in 15 tertiary or university-affiliated hospitals between July 2010 and January 2011 were assessed. Patient data, including NT-pro-BNP levels and Simplified Acute Physiology Score (SAPS) 3 scores, were recorded prospectively in a web-based database. Results: The median age was 64 years (range, 53-73 years), and 906 (62.9%) patients were male. The median NT-pro-BNP level was 341 pg/mL (104-1,637 pg/mL), and the median SAPS 3 score was 57 (range, 47-69). The ICU mortality rate was 18.9%, and hospital mortality was 24.5%. Hospital survivors showed significantly lower NT-pro-BNP values than nonsurvivors (245 pg/mL [range, 82-1,053 pg/mL] vs. 875 pg/mL [241-5,000 pg/mL], respectively; p < 0.001). In prediction of hospital mortality, the area under the curve (AUC) for NT-pro-BNP was 0.67 (95% confidence interval [CI], 0.64-0.70) and SAPS 3 score was 0.83 (95% CI, 0.81-0.85). AUC increment by adding NT-pro-BNP is minimal and likely no different to SAPS 3 alone. Conclusions: The NT-pro-BNP level was more elevated in nonsurvivors in a multicenter cohort of critically ill patients. However, there was little additional prognostic power when adding NT-pro-BNP to SAPS 3 score.

AB - Background: The role of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) as a prognostic factor in patients admitted to the intensive care unit (ICU) is not yet fully established. We aimed to determine whether NT-pro-BNP is predictive of ICU mortality in a multicenter cohort of critically ill patients. Methods: A total of 1440 patients admitted to 22 ICUs (medical, 14; surgical, six; multidisciplinary, two) in 15 tertiary or university-affiliated hospitals between July 2010 and January 2011 were assessed. Patient data, including NT-pro-BNP levels and Simplified Acute Physiology Score (SAPS) 3 scores, were recorded prospectively in a web-based database. Results: The median age was 64 years (range, 53-73 years), and 906 (62.9%) patients were male. The median NT-pro-BNP level was 341 pg/mL (104-1,637 pg/mL), and the median SAPS 3 score was 57 (range, 47-69). The ICU mortality rate was 18.9%, and hospital mortality was 24.5%. Hospital survivors showed significantly lower NT-pro-BNP values than nonsurvivors (245 pg/mL [range, 82-1,053 pg/mL] vs. 875 pg/mL [241-5,000 pg/mL], respectively; p < 0.001). In prediction of hospital mortality, the area under the curve (AUC) for NT-pro-BNP was 0.67 (95% confidence interval [CI], 0.64-0.70) and SAPS 3 score was 0.83 (95% CI, 0.81-0.85). AUC increment by adding NT-pro-BNP is minimal and likely no different to SAPS 3 alone. Conclusions: The NT-pro-BNP level was more elevated in nonsurvivors in a multicenter cohort of critically ill patients. However, there was little additional prognostic power when adding NT-pro-BNP to SAPS 3 score.

KW - Critical care

KW - Intensive care unit

KW - N-terminal pro-B-type natriuretic peptide

KW - Prognosis

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U2 - 10.1186/1471-2253-14-16

DO - 10.1186/1471-2253-14-16

M3 - Article

VL - 14

JO - BMC Anesthesiology

JF - BMC Anesthesiology

SN - 1471-2253

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ER -