Usefulness of neutrophil/lymphocyte ratio as a predictor of atrial fibrillation: A meta-analysis

Qingmiao Shao, Kangyin Chen, Seung-Woon Rha, Hong Euy Lim, Guangping Li, Tong Liu

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background and Aims,. Current evidence suggests that a high neutrophil/lymphocyte ratio (NLR) may increase the risk of atrial fibrillation (AF), but this association is still uncertain. The aim of the comprehensive meta-analysis was to evaluate the potential association between NLR and the risk of AF. Methods. We conducted a systematic literature search using electronic databases (PubMed, Ovid, Embase, Cochrane Database and Web of Science) to identify the studies reporting the association between NLR and risk of AF. We searched the literature published January 2015 or earlier. We used both fixed-effects and random-effects models to calculate the overall effect estimate. An I2 > 50% indicates at least moderate statistical heterogeneity. A sensitivity analysis and subgroup analysis were performed to find the origin of heterogeneity. Results. We retrieved 11 studies involving a total of 2,766 participants. The combined odds ratio (OR) of incident AF for baseline NLR level was 1.25 (95% confidence interval [CI] 1.16-1.35) with significant heterogeneity across studies (I2 = 82.7%, p < 0.01) and for the post-NLR level (following CABG, RFCA and cardioversion) was 1.518 (95% CI 1.076-2.142) with significant heterogeneity across studies (I2 = 93.7%, p = 0.017). We also showed an association between AF recurrence following CABG, RFCA and cardioversion and baseline NLR level (OR 1.517, 95% CI 1.108-2.079) with significant heterogeneity across studies (I2 = 86.8%, p < 0.01). Conclusions. Our comprehensive meta-analysis suggests that the high level of NLR, whether baseline or postsurgery/procedure, is associated with the increased risk of AF recurrence/occurrence.

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalArchives of Medical Research
Volume46
Issue number3
DOIs
Publication statusPublished - 2015

Fingerprint

Atrial Fibrillation
Meta-Analysis
Neutrophils
Lymphocytes
Odds Ratio
Electric Countershock
Confidence Intervals
Databases
Recurrence
PubMed

Keywords

  • Atrial fibrillation
  • Inflammation
  • Marker
  • Meta-analysis
  • Neutrophil/lymphocyte ratio

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Usefulness of neutrophil/lymphocyte ratio as a predictor of atrial fibrillation : A meta-analysis. / Shao, Qingmiao; Chen, Kangyin; Rha, Seung-Woon; Lim, Hong Euy; Li, Guangping; Liu, Tong.

In: Archives of Medical Research, Vol. 46, No. 3, 2015, p. 199-206.

Research output: Contribution to journalArticle

Shao, Qingmiao ; Chen, Kangyin ; Rha, Seung-Woon ; Lim, Hong Euy ; Li, Guangping ; Liu, Tong. / Usefulness of neutrophil/lymphocyte ratio as a predictor of atrial fibrillation : A meta-analysis. In: Archives of Medical Research. 2015 ; Vol. 46, No. 3. pp. 199-206.
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abstract = "Background and Aims,. Current evidence suggests that a high neutrophil/lymphocyte ratio (NLR) may increase the risk of atrial fibrillation (AF), but this association is still uncertain. The aim of the comprehensive meta-analysis was to evaluate the potential association between NLR and the risk of AF. Methods. We conducted a systematic literature search using electronic databases (PubMed, Ovid, Embase, Cochrane Database and Web of Science) to identify the studies reporting the association between NLR and risk of AF. We searched the literature published January 2015 or earlier. We used both fixed-effects and random-effects models to calculate the overall effect estimate. An I2 > 50{\%} indicates at least moderate statistical heterogeneity. A sensitivity analysis and subgroup analysis were performed to find the origin of heterogeneity. Results. We retrieved 11 studies involving a total of 2,766 participants. The combined odds ratio (OR) of incident AF for baseline NLR level was 1.25 (95{\%} confidence interval [CI] 1.16-1.35) with significant heterogeneity across studies (I2 = 82.7{\%}, p < 0.01) and for the post-NLR level (following CABG, RFCA and cardioversion) was 1.518 (95{\%} CI 1.076-2.142) with significant heterogeneity across studies (I2 = 93.7{\%}, p = 0.017). We also showed an association between AF recurrence following CABG, RFCA and cardioversion and baseline NLR level (OR 1.517, 95{\%} CI 1.108-2.079) with significant heterogeneity across studies (I2 = 86.8{\%}, p < 0.01). Conclusions. Our comprehensive meta-analysis suggests that the high level of NLR, whether baseline or postsurgery/procedure, is associated with the increased risk of AF recurrence/occurrence.",
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N2 - Background and Aims,. Current evidence suggests that a high neutrophil/lymphocyte ratio (NLR) may increase the risk of atrial fibrillation (AF), but this association is still uncertain. The aim of the comprehensive meta-analysis was to evaluate the potential association between NLR and the risk of AF. Methods. We conducted a systematic literature search using electronic databases (PubMed, Ovid, Embase, Cochrane Database and Web of Science) to identify the studies reporting the association between NLR and risk of AF. We searched the literature published January 2015 or earlier. We used both fixed-effects and random-effects models to calculate the overall effect estimate. An I2 > 50% indicates at least moderate statistical heterogeneity. A sensitivity analysis and subgroup analysis were performed to find the origin of heterogeneity. Results. We retrieved 11 studies involving a total of 2,766 participants. The combined odds ratio (OR) of incident AF for baseline NLR level was 1.25 (95% confidence interval [CI] 1.16-1.35) with significant heterogeneity across studies (I2 = 82.7%, p < 0.01) and for the post-NLR level (following CABG, RFCA and cardioversion) was 1.518 (95% CI 1.076-2.142) with significant heterogeneity across studies (I2 = 93.7%, p = 0.017). We also showed an association between AF recurrence following CABG, RFCA and cardioversion and baseline NLR level (OR 1.517, 95% CI 1.108-2.079) with significant heterogeneity across studies (I2 = 86.8%, p < 0.01). Conclusions. Our comprehensive meta-analysis suggests that the high level of NLR, whether baseline or postsurgery/procedure, is associated with the increased risk of AF recurrence/occurrence.

AB - Background and Aims,. Current evidence suggests that a high neutrophil/lymphocyte ratio (NLR) may increase the risk of atrial fibrillation (AF), but this association is still uncertain. The aim of the comprehensive meta-analysis was to evaluate the potential association between NLR and the risk of AF. Methods. We conducted a systematic literature search using electronic databases (PubMed, Ovid, Embase, Cochrane Database and Web of Science) to identify the studies reporting the association between NLR and risk of AF. We searched the literature published January 2015 or earlier. We used both fixed-effects and random-effects models to calculate the overall effect estimate. An I2 > 50% indicates at least moderate statistical heterogeneity. A sensitivity analysis and subgroup analysis were performed to find the origin of heterogeneity. Results. We retrieved 11 studies involving a total of 2,766 participants. The combined odds ratio (OR) of incident AF for baseline NLR level was 1.25 (95% confidence interval [CI] 1.16-1.35) with significant heterogeneity across studies (I2 = 82.7%, p < 0.01) and for the post-NLR level (following CABG, RFCA and cardioversion) was 1.518 (95% CI 1.076-2.142) with significant heterogeneity across studies (I2 = 93.7%, p = 0.017). We also showed an association between AF recurrence following CABG, RFCA and cardioversion and baseline NLR level (OR 1.517, 95% CI 1.108-2.079) with significant heterogeneity across studies (I2 = 86.8%, p < 0.01). Conclusions. Our comprehensive meta-analysis suggests that the high level of NLR, whether baseline or postsurgery/procedure, is associated with the increased risk of AF recurrence/occurrence.

KW - Atrial fibrillation

KW - Inflammation

KW - Marker

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KW - Neutrophil/lymphocyte ratio

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