Abstract
The purpose of this prospective study was to verify and compare the strengths of various blood markers and fibrosis models in predicting significant liver fibrosis. One hundred fifty-eight patients with chronic liver disease who underwent liver biopsy were enrolled. The mean age was 41 yr and male patients accounted for 70.2%. The common causes of liver disease were hepatitis B (67.7%) and C (16.5%) and fatty liver (9.5%). Stages of liver fibrosis (F0-4) were assessed according to the Batts and Ludwig scoring system. Significant fibrosis was defined as ≥F2. Sixteen blood markers were measured along with liver biopsy, and estimates of hepatic fibrosis were calculated using various predictive models. Predictive accuracy was evaluated with a receiver-operating characteristics (ROC) curve. Liver biopsy revealed significant fibrosis in 106 cases (67.1%). On multivariate analysis, α2-macroglobulin, hyaluronic acid, and haptoglobin were found to be independently related to significant hepatic fibrosis. A new predictive model was constructed based on these variables, and its area under the ROC curve was 0.91 (95% confidence interval, 0.85-0.96). In conclusion, α2-macroglobulin, hyaluronic acid, and haptoglobin levels are independent predictors for significant hepatic fibrosis in chronic liver disease.
| Original language | English |
|---|---|
| Pages (from-to) | 67-74 |
| Number of pages | 8 |
| Journal | Journal of Korean Medical Science |
| Volume | 25 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 Jan 1 |
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Keywords
- Biological markers
- Chronic liver disease
- Liver cirrhosis
ASJC Scopus subject areas
- Medicine(all)
Cite this
Usefulness of non-invasive markers for predicting significant fibrosis in patients with chronic liver disease. / Lee, Han Hyo; Seo, Yeon Seok; Um, Soon-Ho; Won, Nam Hee; Yoo, Hanna; Jung, Eun Suk; Kwon, Yong Dae; Park, Sanghoon; Keum, Bora; Kim, Yong Sik; Yim, Hyung Joon; Jeen, Yoon Tae; Chun, Hoon-Jai; Kim, Chang Duck; Ryu, Ho Sang.
In: Journal of Korean Medical Science, Vol. 25, No. 1, 01.01.2010, p. 67-74.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Usefulness of non-invasive markers for predicting significant fibrosis in patients with chronic liver disease
AU - Lee, Han Hyo
AU - Seo, Yeon Seok
AU - Um, Soon-Ho
AU - Won, Nam Hee
AU - Yoo, Hanna
AU - Jung, Eun Suk
AU - Kwon, Yong Dae
AU - Park, Sanghoon
AU - Keum, Bora
AU - Kim, Yong Sik
AU - Yim, Hyung Joon
AU - Jeen, Yoon Tae
AU - Chun, Hoon-Jai
AU - Kim, Chang Duck
AU - Ryu, Ho Sang
PY - 2010/1/1
Y1 - 2010/1/1
N2 - The purpose of this prospective study was to verify and compare the strengths of various blood markers and fibrosis models in predicting significant liver fibrosis. One hundred fifty-eight patients with chronic liver disease who underwent liver biopsy were enrolled. The mean age was 41 yr and male patients accounted for 70.2%. The common causes of liver disease were hepatitis B (67.7%) and C (16.5%) and fatty liver (9.5%). Stages of liver fibrosis (F0-4) were assessed according to the Batts and Ludwig scoring system. Significant fibrosis was defined as ≥F2. Sixteen blood markers were measured along with liver biopsy, and estimates of hepatic fibrosis were calculated using various predictive models. Predictive accuracy was evaluated with a receiver-operating characteristics (ROC) curve. Liver biopsy revealed significant fibrosis in 106 cases (67.1%). On multivariate analysis, α2-macroglobulin, hyaluronic acid, and haptoglobin were found to be independently related to significant hepatic fibrosis. A new predictive model was constructed based on these variables, and its area under the ROC curve was 0.91 (95% confidence interval, 0.85-0.96). In conclusion, α2-macroglobulin, hyaluronic acid, and haptoglobin levels are independent predictors for significant hepatic fibrosis in chronic liver disease.
AB - The purpose of this prospective study was to verify and compare the strengths of various blood markers and fibrosis models in predicting significant liver fibrosis. One hundred fifty-eight patients with chronic liver disease who underwent liver biopsy were enrolled. The mean age was 41 yr and male patients accounted for 70.2%. The common causes of liver disease were hepatitis B (67.7%) and C (16.5%) and fatty liver (9.5%). Stages of liver fibrosis (F0-4) were assessed according to the Batts and Ludwig scoring system. Significant fibrosis was defined as ≥F2. Sixteen blood markers were measured along with liver biopsy, and estimates of hepatic fibrosis were calculated using various predictive models. Predictive accuracy was evaluated with a receiver-operating characteristics (ROC) curve. Liver biopsy revealed significant fibrosis in 106 cases (67.1%). On multivariate analysis, α2-macroglobulin, hyaluronic acid, and haptoglobin were found to be independently related to significant hepatic fibrosis. A new predictive model was constructed based on these variables, and its area under the ROC curve was 0.91 (95% confidence interval, 0.85-0.96). In conclusion, α2-macroglobulin, hyaluronic acid, and haptoglobin levels are independent predictors for significant hepatic fibrosis in chronic liver disease.
KW - Biological markers
KW - Chronic liver disease
KW - Liver cirrhosis
UR - http://www.scopus.com/inward/record.url?scp=77949330366&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949330366&partnerID=8YFLogxK
U2 - 10.3346/jkms.2010.25.1.67
DO - 10.3346/jkms.2010.25.1.67
M3 - Article
C2 - 20052350
AN - SCOPUS:77949330366
VL - 25
SP - 67
EP - 74
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
SN - 1011-8934
IS - 1
ER -