Usefulness of thallium-201 SPECT for prediction of early progression in low-grade astrocytomas diagnosed by stereotactic biopsy

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Abstract

Objective: To establish the value of thallium-201 single-photon emission computed tomography (201Tl-SPECT) as a predictor of early progression in low-grade astrocytomas (LGAs). Methods: We studied 57 consecutive patients who underwent 201 Tl-SPECT before stereotactic biopsy (n = 33) or surgical resection (n = 24). The value of radiologic and histopathological variables (201Tl index and MIB-1 index) in predicting progression free survival (PFS) was examined in each group of patients. Results: During a median follow up of 55 months (range, 11-101), progression of the primary lesion was identified in 46 patients (80.7%). Based on Cox's proportional hazards model, the increased thallium uptake was associated with a short PFS in both biopsy and resection groups, whereas the MIB-1 index was significant only in the resection group. Considering the cut-off value, 201Tl index > 1.7 was statistically significant for reduced PFS in the biopsy group; however, MIB-1 index was not directly related to the PFS at any level. For the surgical resection group, both a 201Tl index > 1.9 and a MIB-1 index > 6% were associated with short PFS. Conclusion: 201Tl SPECT may play a role in prediction of early tumor progression not only in resected LGAs, but also in biopsy-proven LGAs. Therefore, we suggest that patients with LGAs established from biopsy should be considered as high-risk groups for early progression if the tumor shows a high 201Tl uptake, even if the tumor demonstrates low proliferative activity on histopathologic examination.

Original languageEnglish
Pages (from-to)223-229
Number of pages7
JournalClinical Neurology and Neurosurgery
Volume114
Issue number3
DOIs
Publication statusPublished - 2012 Apr 1

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Thallium
Astrocytoma
Single-Photon Emission-Computed Tomography
Disease-Free Survival
Biopsy
Neoplasms
Proportional Hazards Models

Keywords

  • Biopsy
  • Low-grade astrocytoma
  • Progression-free survival
  • Single-photon emission computed tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

@article{474770772cfd4dc9b7a4e364555dadd7,
title = "Usefulness of thallium-201 SPECT for prediction of early progression in low-grade astrocytomas diagnosed by stereotactic biopsy",
abstract = "Objective: To establish the value of thallium-201 single-photon emission computed tomography (201Tl-SPECT) as a predictor of early progression in low-grade astrocytomas (LGAs). Methods: We studied 57 consecutive patients who underwent 201 Tl-SPECT before stereotactic biopsy (n = 33) or surgical resection (n = 24). The value of radiologic and histopathological variables (201Tl index and MIB-1 index) in predicting progression free survival (PFS) was examined in each group of patients. Results: During a median follow up of 55 months (range, 11-101), progression of the primary lesion was identified in 46 patients (80.7{\%}). Based on Cox's proportional hazards model, the increased thallium uptake was associated with a short PFS in both biopsy and resection groups, whereas the MIB-1 index was significant only in the resection group. Considering the cut-off value, 201Tl index > 1.7 was statistically significant for reduced PFS in the biopsy group; however, MIB-1 index was not directly related to the PFS at any level. For the surgical resection group, both a 201Tl index > 1.9 and a MIB-1 index > 6{\%} were associated with short PFS. Conclusion: 201Tl SPECT may play a role in prediction of early tumor progression not only in resected LGAs, but also in biopsy-proven LGAs. Therefore, we suggest that patients with LGAs established from biopsy should be considered as high-risk groups for early progression if the tumor shows a high 201Tl uptake, even if the tumor demonstrates low proliferative activity on histopathologic examination.",
keywords = "Biopsy, Low-grade astrocytoma, Progression-free survival, Single-photon emission computed tomography",
author = "Kyung-Jae Park and Shin-Hyuk Kang and Dong-Hyuk Park and Cho, {Tai Hyoung} and Jae-Gol Choe and Chung, {Yong Gu}",
year = "2012",
month = "4",
day = "1",
doi = "10.1016/j.clineuro.2011.10.023",
language = "English",
volume = "114",
pages = "223--229",
journal = "Clinical Neurology and Neurosurgery",
issn = "0303-8467",
publisher = "Elsevier",
number = "3",

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TY - JOUR

T1 - Usefulness of thallium-201 SPECT for prediction of early progression in low-grade astrocytomas diagnosed by stereotactic biopsy

AU - Park, Kyung-Jae

AU - Kang, Shin-Hyuk

AU - Park, Dong-Hyuk

AU - Cho, Tai Hyoung

AU - Choe, Jae-Gol

AU - Chung, Yong Gu

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Objective: To establish the value of thallium-201 single-photon emission computed tomography (201Tl-SPECT) as a predictor of early progression in low-grade astrocytomas (LGAs). Methods: We studied 57 consecutive patients who underwent 201 Tl-SPECT before stereotactic biopsy (n = 33) or surgical resection (n = 24). The value of radiologic and histopathological variables (201Tl index and MIB-1 index) in predicting progression free survival (PFS) was examined in each group of patients. Results: During a median follow up of 55 months (range, 11-101), progression of the primary lesion was identified in 46 patients (80.7%). Based on Cox's proportional hazards model, the increased thallium uptake was associated with a short PFS in both biopsy and resection groups, whereas the MIB-1 index was significant only in the resection group. Considering the cut-off value, 201Tl index > 1.7 was statistically significant for reduced PFS in the biopsy group; however, MIB-1 index was not directly related to the PFS at any level. For the surgical resection group, both a 201Tl index > 1.9 and a MIB-1 index > 6% were associated with short PFS. Conclusion: 201Tl SPECT may play a role in prediction of early tumor progression not only in resected LGAs, but also in biopsy-proven LGAs. Therefore, we suggest that patients with LGAs established from biopsy should be considered as high-risk groups for early progression if the tumor shows a high 201Tl uptake, even if the tumor demonstrates low proliferative activity on histopathologic examination.

AB - Objective: To establish the value of thallium-201 single-photon emission computed tomography (201Tl-SPECT) as a predictor of early progression in low-grade astrocytomas (LGAs). Methods: We studied 57 consecutive patients who underwent 201 Tl-SPECT before stereotactic biopsy (n = 33) or surgical resection (n = 24). The value of radiologic and histopathological variables (201Tl index and MIB-1 index) in predicting progression free survival (PFS) was examined in each group of patients. Results: During a median follow up of 55 months (range, 11-101), progression of the primary lesion was identified in 46 patients (80.7%). Based on Cox's proportional hazards model, the increased thallium uptake was associated with a short PFS in both biopsy and resection groups, whereas the MIB-1 index was significant only in the resection group. Considering the cut-off value, 201Tl index > 1.7 was statistically significant for reduced PFS in the biopsy group; however, MIB-1 index was not directly related to the PFS at any level. For the surgical resection group, both a 201Tl index > 1.9 and a MIB-1 index > 6% were associated with short PFS. Conclusion: 201Tl SPECT may play a role in prediction of early tumor progression not only in resected LGAs, but also in biopsy-proven LGAs. Therefore, we suggest that patients with LGAs established from biopsy should be considered as high-risk groups for early progression if the tumor shows a high 201Tl uptake, even if the tumor demonstrates low proliferative activity on histopathologic examination.

KW - Biopsy

KW - Low-grade astrocytoma

KW - Progression-free survival

KW - Single-photon emission computed tomography

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JO - Clinical Neurology and Neurosurgery

JF - Clinical Neurology and Neurosurgery

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