Usefulness of the psoriatic arthritis screening and evaluation questionnaire to monitor disease activity in management of patients with psoriasis: Findings from the EPI-PSODE study

Yong Beom Choe, Chul Jong Park, Dae Young Yu, Youngdoe Kim, Hyun Jeong Ju, Sang Woong Youn, Joo Heung Lee, Byung Soo Kim, Seong Jun Seo, Seok Kweon Yun, Joonsoo Park, Nack In Kim, Jai Il Youn, Seok Jong Lee, Min Geol Lee, Kwang Joong Kim, Young Suck Ro, Hae Jun Song, Bong Seok Shin, Sung Ku AhnJi Yeoun Lee, Young Ho Won, Min Soo Jang, Ki Ho Kim, Myung Hwa Kim, Tae Yoon Kim, Jee Ho Choi

Research output: Contribution to journalArticle

Abstract

Background: Psoriasis and psoriatic arthritis (PsA) are included in the group of immune-mediated inflammatory diseases (IMIDs) caused by systemic inflammation; however, indicators for monitoring inflammatory activity in patients with psoriasis, such as the Psoriasis Area and Severity Index (PASI), are limited. Objective: To determine whether the Psoriatic Arthritis Screening and Evaluation (PASE) questionnaire can be used to monitor disease activity in patients with psoriasis. Methods: This was a multicenter, non-interventional, cross-sectional study. Demographic factors and PASI and PASE scores were collected to investigate associations between each. Results: PASE data were available for 1,255 patients, of whom 498 (39.7%) had a score of ≥37. Compared with the group with PASE score <37, the group with score ≥37 had a higher proportion of women (34.9% vs. 48.8%, p<0.0001), older mean age at diagnosis (36.4 vs. 41.7 years, p<0.0001), more severe disease activity using PASI and body surface area measures (p=0.0021 and p=0.0008, respectively), and higher mean body mass index (23.7 vs. 24.1, p=0.0411). In a multiple linear regression model, PASE score was positively associated with cutaneous disease activity (p<0.0001). Conclusion: After risk-adjustment, PASE was positively associated with PASI, which suggests that PASE can be sensitive to disease activity. Since psoriasis is regarded as one of the IMIDs, PASE may be utilized as a tool not only to screen PsA but also to monitor disease activity.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalAnnals of Dermatology
Volume31
Issue number1
DOIs
Publication statusPublished - 2019 Feb 1

Keywords

  • Arthritis
  • Psoriatic

ASJC Scopus subject areas

  • Dermatology

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    Choe, Y. B., Park, C. J., Yu, D. Y., Kim, Y., Ju, H. J., Youn, S. W., Lee, J. H., Kim, B. S., Seo, S. J., Yun, S. K., Park, J., Kim, N. I., Youn, J. I., Lee, S. J., Lee, M. G., Kim, K. J., Ro, Y. S., Song, H. J., Shin, B. S., ... Choi, J. H. (2019). Usefulness of the psoriatic arthritis screening and evaluation questionnaire to monitor disease activity in management of patients with psoriasis: Findings from the EPI-PSODE study. Annals of Dermatology, 31(1), 29-36. https://doi.org/10.5021/ad.2019.31.1.29