Using intravoxel incoherent motion (IVIM) MR imaging to predict lipiodol uptake in patients with hepatocellular carcinoma following transcatheter arterial chemoembolization: A preliminary result

Yang Shin Park, Chang Hee Lee, Ji Hoon Kim, In Seong Kim, Berthold Kiefer, Tae Seok Seo, Kyeong Ah Kim, Cheol Min Park

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    34 Citations (Scopus)

    Abstract

    Purpose: To assess the usefulness of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) for predicting lipiodol uptake in patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). Materials and methods: The institutional review board approved this study. 44 HCC patients underwent IVIM-DWI and Gd-EOB-DTPA-enhanced MRI prior to TACE. Using post-TACE CT as a reference standard, each HCC was classified into either lipiodol good uptake (LGU) or poor uptake (LPU) group. Apparent diffusion coefficient (ADC), true diffusion coefficient (D), perfusion coefficient (D*), and perfusion fraction (f) in HCC were calculated. Arterial enhancement ratio (AER) and IVIM parameters were compared between those two groups using the Mann-Whitney U test. Results: Of the 51 HCCs, 37 (72.5%) were LGU group and 14 (27.5%) were LPU group. AER of HCC was significantly higher in LGU than LPU (0.99. ± 0.54 and 0.67. ± 0.45; P= .034). ADC, D, and f values were not significantly different (P= .073, .059, and .196, respectively) between these two groups. D* was significantly elevated in LGU than LPU (48.10. ± 15.33 and 26.75. ± 9.55; P= .001). Conclusion: Both AER derived from contrast enhanced MRI and D* values derived from IVIM-DWI for HCC were significantly higher in LGU than in LPU. These parameters would be helpful for predicting the lipiodol uptake.

    Original languageEnglish
    Pages (from-to)638-646
    Number of pages9
    JournalMagnetic Resonance Imaging
    Volume32
    Issue number6
    DOIs
    Publication statusPublished - 2014 Jul

    Keywords

    • DWI
    • Hepatocellular carcinoma
    • IVIM
    • Liver
    • MRI
    • TACE

    ASJC Scopus subject areas

    • Biophysics
    • Biomedical Engineering
    • Radiology Nuclear Medicine and imaging

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