Using intravoxel incoherent motion (IVIM) MR imaging to predict lipiodol uptake in patients with hepatocellular carcinoma following transcatheter arterial chemoembolization: A preliminary result

Yang Shin Park, Chang-Hee Lee, Ji Hoon Kim, In Seong Kim, Berthold Kiefer, Tae-Seok Seo, Kyeong Ah Kim, Cheol Min Park

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Abstract

Purpose: To assess the usefulness of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) for predicting lipiodol uptake in patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). Materials and methods: The institutional review board approved this study. 44 HCC patients underwent IVIM-DWI and Gd-EOB-DTPA-enhanced MRI prior to TACE. Using post-TACE CT as a reference standard, each HCC was classified into either lipiodol good uptake (LGU) or poor uptake (LPU) group. Apparent diffusion coefficient (ADC), true diffusion coefficient (D), perfusion coefficient (D*), and perfusion fraction (f) in HCC were calculated. Arterial enhancement ratio (AER) and IVIM parameters were compared between those two groups using the Mann-Whitney U test. Results: Of the 51 HCCs, 37 (72.5%) were LGU group and 14 (27.5%) were LPU group. AER of HCC was significantly higher in LGU than LPU (0.99. ± 0.54 and 0.67. ± 0.45; P= .034). ADC, D, and f values were not significantly different (P= .073, .059, and .196, respectively) between these two groups. D* was significantly elevated in LGU than LPU (48.10. ± 15.33 and 26.75. ± 9.55; P= .001). Conclusion: Both AER derived from contrast enhanced MRI and D* values derived from IVIM-DWI for HCC were significantly higher in LGU than in LPU. These parameters would be helpful for predicting the lipiodol uptake.

Original languageEnglish
Pages (from-to)638-646
Number of pages9
JournalMagnetic Resonance Imaging
Volume32
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

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Ethiodized Oil
Hepatocellular Carcinoma
Imaging techniques
Magnetic resonance imaging
Perfusion
Research Ethics Committees
Nonparametric Statistics

Keywords

  • DWI
  • Hepatocellular carcinoma
  • IVIM
  • Liver
  • MRI
  • TACE

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

@article{6cca0e53ad2f481da65babd2cca9161b,
title = "Using intravoxel incoherent motion (IVIM) MR imaging to predict lipiodol uptake in patients with hepatocellular carcinoma following transcatheter arterial chemoembolization: A preliminary result",
abstract = "Purpose: To assess the usefulness of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) for predicting lipiodol uptake in patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). Materials and methods: The institutional review board approved this study. 44 HCC patients underwent IVIM-DWI and Gd-EOB-DTPA-enhanced MRI prior to TACE. Using post-TACE CT as a reference standard, each HCC was classified into either lipiodol good uptake (LGU) or poor uptake (LPU) group. Apparent diffusion coefficient (ADC), true diffusion coefficient (D), perfusion coefficient (D*), and perfusion fraction (f) in HCC were calculated. Arterial enhancement ratio (AER) and IVIM parameters were compared between those two groups using the Mann-Whitney U test. Results: Of the 51 HCCs, 37 (72.5{\%}) were LGU group and 14 (27.5{\%}) were LPU group. AER of HCC was significantly higher in LGU than LPU (0.99. ± 0.54 and 0.67. ± 0.45; P= .034). ADC, D, and f values were not significantly different (P= .073, .059, and .196, respectively) between these two groups. D* was significantly elevated in LGU than LPU (48.10. ± 15.33 and 26.75. ± 9.55; P= .001). Conclusion: Both AER derived from contrast enhanced MRI and D* values derived from IVIM-DWI for HCC were significantly higher in LGU than in LPU. These parameters would be helpful for predicting the lipiodol uptake.",
keywords = "DWI, Hepatocellular carcinoma, IVIM, Liver, MRI, TACE",
author = "Park, {Yang Shin} and Chang-Hee Lee and Kim, {Ji Hoon} and Kim, {In Seong} and Berthold Kiefer and Tae-Seok Seo and Kim, {Kyeong Ah} and Park, {Cheol Min}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.mri.2014.03.003",
language = "English",
volume = "32",
pages = "638--646",
journal = "Magnetic Resonance Imaging",
issn = "0730-725X",
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TY - JOUR

T1 - Using intravoxel incoherent motion (IVIM) MR imaging to predict lipiodol uptake in patients with hepatocellular carcinoma following transcatheter arterial chemoembolization

T2 - A preliminary result

AU - Park, Yang Shin

AU - Lee, Chang-Hee

AU - Kim, Ji Hoon

AU - Kim, In Seong

AU - Kiefer, Berthold

AU - Seo, Tae-Seok

AU - Kim, Kyeong Ah

AU - Park, Cheol Min

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose: To assess the usefulness of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) for predicting lipiodol uptake in patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). Materials and methods: The institutional review board approved this study. 44 HCC patients underwent IVIM-DWI and Gd-EOB-DTPA-enhanced MRI prior to TACE. Using post-TACE CT as a reference standard, each HCC was classified into either lipiodol good uptake (LGU) or poor uptake (LPU) group. Apparent diffusion coefficient (ADC), true diffusion coefficient (D), perfusion coefficient (D*), and perfusion fraction (f) in HCC were calculated. Arterial enhancement ratio (AER) and IVIM parameters were compared between those two groups using the Mann-Whitney U test. Results: Of the 51 HCCs, 37 (72.5%) were LGU group and 14 (27.5%) were LPU group. AER of HCC was significantly higher in LGU than LPU (0.99. ± 0.54 and 0.67. ± 0.45; P= .034). ADC, D, and f values were not significantly different (P= .073, .059, and .196, respectively) between these two groups. D* was significantly elevated in LGU than LPU (48.10. ± 15.33 and 26.75. ± 9.55; P= .001). Conclusion: Both AER derived from contrast enhanced MRI and D* values derived from IVIM-DWI for HCC were significantly higher in LGU than in LPU. These parameters would be helpful for predicting the lipiodol uptake.

AB - Purpose: To assess the usefulness of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) for predicting lipiodol uptake in patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). Materials and methods: The institutional review board approved this study. 44 HCC patients underwent IVIM-DWI and Gd-EOB-DTPA-enhanced MRI prior to TACE. Using post-TACE CT as a reference standard, each HCC was classified into either lipiodol good uptake (LGU) or poor uptake (LPU) group. Apparent diffusion coefficient (ADC), true diffusion coefficient (D), perfusion coefficient (D*), and perfusion fraction (f) in HCC were calculated. Arterial enhancement ratio (AER) and IVIM parameters were compared between those two groups using the Mann-Whitney U test. Results: Of the 51 HCCs, 37 (72.5%) were LGU group and 14 (27.5%) were LPU group. AER of HCC was significantly higher in LGU than LPU (0.99. ± 0.54 and 0.67. ± 0.45; P= .034). ADC, D, and f values were not significantly different (P= .073, .059, and .196, respectively) between these two groups. D* was significantly elevated in LGU than LPU (48.10. ± 15.33 and 26.75. ± 9.55; P= .001). Conclusion: Both AER derived from contrast enhanced MRI and D* values derived from IVIM-DWI for HCC were significantly higher in LGU than in LPU. These parameters would be helpful for predicting the lipiodol uptake.

KW - DWI

KW - Hepatocellular carcinoma

KW - IVIM

KW - Liver

KW - MRI

KW - TACE

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U2 - 10.1016/j.mri.2014.03.003

DO - 10.1016/j.mri.2014.03.003

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