Using intravoxel incoherent motion MR imaging to evaluate cortical defects in the first episode of upper urinary tract infections: Preliminary results

Chang-Hee Lee, Kee Hwan Yoo, Bo-Kyung Je, In Seong Kim, Berthold Kiefer, Yang Shin Park, Kyeong Ah Kim, Cheol Min Park

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose To compare intravoxel incoherent motion diffusion weight imaging IVIM-DWI MRI with DMSA for the evaluation of cortical defect in pediatric upper urinary tract infection (UTI) patients. Materials and Methods Forty-three kidneys of 22 pediatric patients with the first episode of febrile upper UTI were evaluated. DWI using IVIM model was performed with eight b factors. The presence of cortical defect was evaluated on apparent diffusion coefficient (ADC) map. DMSA was used as the standard of reference. ADC, true diffusion coefficient (D), pseudo-diffusion coefficient (D), and perfusion fraction (F) in both defect and nondefect area were calculated and compared. Results Cortical defects were detected in 14 kidneys by IVIM-DWI. The sensitivity, specificity, positive predictive value, and negative predictive value of IVIM-DWI MRI for the detection of defects was 93.3%, 100%, 100%, and 96.5%, respectively. Mean values of ADC, D, D, and F were 1.12 ± 0.15, 1.05 ± 0.10, 33 ± 17 (× 10-3 mm2/s), and 0.14 ± 0.09 in the defect foci. In normal foci, ADC, D, D, and F were 1.37 ± 0.09, 1.31 ± 0.10, 43 ± 19 (× 10-3 mm2/s), and 0.12 ± 0.04, respectively. ADC and D were significantly lower in defect group than nondefect group (P < 0.01). Conclusion IVIM-DWI can allow both direct visualization and quantitative measurement of cortical defects.

Original languageEnglish
Pages (from-to)545-551
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume40
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Urinary Tract Infections
Succimer
Pediatrics
Kidney
Fever
Perfusion
Weights and Measures
Sensitivity and Specificity

Keywords

  • APN
  • DWI
  • IVIM
  • kidney
  • MRI
  • pediatrics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{f5d5319fab2e4cb39533d7ab0552356c,
title = "Using intravoxel incoherent motion MR imaging to evaluate cortical defects in the first episode of upper urinary tract infections: Preliminary results",
abstract = "Purpose To compare intravoxel incoherent motion diffusion weight imaging IVIM-DWI MRI with DMSA for the evaluation of cortical defect in pediatric upper urinary tract infection (UTI) patients. Materials and Methods Forty-three kidneys of 22 pediatric patients with the first episode of febrile upper UTI were evaluated. DWI using IVIM model was performed with eight b factors. The presence of cortical defect was evaluated on apparent diffusion coefficient (ADC) map. DMSA was used as the standard of reference. ADC, true diffusion coefficient (D), pseudo-diffusion coefficient (D), and perfusion fraction (F) in both defect and nondefect area were calculated and compared. Results Cortical defects were detected in 14 kidneys by IVIM-DWI. The sensitivity, specificity, positive predictive value, and negative predictive value of IVIM-DWI MRI for the detection of defects was 93.3{\%}, 100{\%}, 100{\%}, and 96.5{\%}, respectively. Mean values of ADC, D, D, and F were 1.12 ± 0.15, 1.05 ± 0.10, 33 ± 17 (× 10-3 mm2/s), and 0.14 ± 0.09 in the defect foci. In normal foci, ADC, D, D, and F were 1.37 ± 0.09, 1.31 ± 0.10, 43 ± 19 (× 10-3 mm2/s), and 0.12 ± 0.04, respectively. ADC and D were significantly lower in defect group than nondefect group (P < 0.01). Conclusion IVIM-DWI can allow both direct visualization and quantitative measurement of cortical defects.",
keywords = "APN, DWI, IVIM, kidney, MRI, pediatrics",
author = "Chang-Hee Lee and Yoo, {Kee Hwan} and Bo-Kyung Je and Kim, {In Seong} and Berthold Kiefer and Park, {Yang Shin} and Kim, {Kyeong Ah} and Park, {Cheol Min}",
year = "2014",
month = "1",
day = "1",
doi = "10.1002/jmri.24384",
language = "English",
volume = "40",
pages = "545--551",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Using intravoxel incoherent motion MR imaging to evaluate cortical defects in the first episode of upper urinary tract infections

T2 - Preliminary results

AU - Lee, Chang-Hee

AU - Yoo, Kee Hwan

AU - Je, Bo-Kyung

AU - Kim, In Seong

AU - Kiefer, Berthold

AU - Park, Yang Shin

AU - Kim, Kyeong Ah

AU - Park, Cheol Min

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose To compare intravoxel incoherent motion diffusion weight imaging IVIM-DWI MRI with DMSA for the evaluation of cortical defect in pediatric upper urinary tract infection (UTI) patients. Materials and Methods Forty-three kidneys of 22 pediatric patients with the first episode of febrile upper UTI were evaluated. DWI using IVIM model was performed with eight b factors. The presence of cortical defect was evaluated on apparent diffusion coefficient (ADC) map. DMSA was used as the standard of reference. ADC, true diffusion coefficient (D), pseudo-diffusion coefficient (D), and perfusion fraction (F) in both defect and nondefect area were calculated and compared. Results Cortical defects were detected in 14 kidneys by IVIM-DWI. The sensitivity, specificity, positive predictive value, and negative predictive value of IVIM-DWI MRI for the detection of defects was 93.3%, 100%, 100%, and 96.5%, respectively. Mean values of ADC, D, D, and F were 1.12 ± 0.15, 1.05 ± 0.10, 33 ± 17 (× 10-3 mm2/s), and 0.14 ± 0.09 in the defect foci. In normal foci, ADC, D, D, and F were 1.37 ± 0.09, 1.31 ± 0.10, 43 ± 19 (× 10-3 mm2/s), and 0.12 ± 0.04, respectively. ADC and D were significantly lower in defect group than nondefect group (P < 0.01). Conclusion IVIM-DWI can allow both direct visualization and quantitative measurement of cortical defects.

AB - Purpose To compare intravoxel incoherent motion diffusion weight imaging IVIM-DWI MRI with DMSA for the evaluation of cortical defect in pediatric upper urinary tract infection (UTI) patients. Materials and Methods Forty-three kidneys of 22 pediatric patients with the first episode of febrile upper UTI were evaluated. DWI using IVIM model was performed with eight b factors. The presence of cortical defect was evaluated on apparent diffusion coefficient (ADC) map. DMSA was used as the standard of reference. ADC, true diffusion coefficient (D), pseudo-diffusion coefficient (D), and perfusion fraction (F) in both defect and nondefect area were calculated and compared. Results Cortical defects were detected in 14 kidneys by IVIM-DWI. The sensitivity, specificity, positive predictive value, and negative predictive value of IVIM-DWI MRI for the detection of defects was 93.3%, 100%, 100%, and 96.5%, respectively. Mean values of ADC, D, D, and F were 1.12 ± 0.15, 1.05 ± 0.10, 33 ± 17 (× 10-3 mm2/s), and 0.14 ± 0.09 in the defect foci. In normal foci, ADC, D, D, and F were 1.37 ± 0.09, 1.31 ± 0.10, 43 ± 19 (× 10-3 mm2/s), and 0.12 ± 0.04, respectively. ADC and D were significantly lower in defect group than nondefect group (P < 0.01). Conclusion IVIM-DWI can allow both direct visualization and quantitative measurement of cortical defects.

KW - APN

KW - DWI

KW - IVIM

KW - kidney

KW - MRI

KW - pediatrics

UR - http://www.scopus.com/inward/record.url?scp=84906094548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906094548&partnerID=8YFLogxK

U2 - 10.1002/jmri.24384

DO - 10.1002/jmri.24384

M3 - Article

C2 - 24757067

AN - SCOPUS:84906094548

VL - 40

SP - 545

EP - 551

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 3

ER -