Utilization of retrograded waxy maize starch gels as tablet matrix for controlled release of theophylline

H. S. Yoon, J. H. Lee, Seung Taik Lim

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Theophylline tablets were prepared using waxy maize starch gels and the effect of retrogradation on the release of theophylline was investigated. Slurries of starch and theophylline were autoclaved in a polypropylene tablet mold and then stored at 4 °C or cycled at 4/30 °C for 8 days. By increasing the period of retrogradation at 4 °C the size of air cells in freeze-dried gels was decreased and the cell walls became thinner. Retrogradation reduced the pore size of the gels and hindered gel swelling in an amylase-containing dissolution medium. These effects became more significant with temperature cycles. The resistance to enzymatic erosion and decreased swelling by the retrogradation under 4/30 °C cycles resulted in a retarded release of theophylline. Thus, temperature-cycled retrogradation of a waxy maize starch gel provided a compact matrix structure that effectively retarded the drug release.

Original languageEnglish
Pages (from-to)449-453
Number of pages5
JournalCarbohydrate Polymers
Volume76
Issue number3
DOIs
Publication statusPublished - 2009 Apr 9

Fingerprint

Theophylline
Starch
Tablets
Gels
Swelling
Amylases
Polypropylenes
Slurries
Pore size
Erosion
Dissolution
Cells
Temperature
Air
Pharmaceutical Preparations

Keywords

  • Gel
  • Release
  • Retrogradation
  • Starch
  • Tablet
  • Theophylline

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Utilization of retrograded waxy maize starch gels as tablet matrix for controlled release of theophylline. / Yoon, H. S.; Lee, J. H.; Lim, Seung Taik.

In: Carbohydrate Polymers, Vol. 76, No. 3, 09.04.2009, p. 449-453.

Research output: Contribution to journalArticle

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