Abstract
Theophylline tablets were prepared using waxy maize starch gels and the effect of retrogradation on the release of theophylline was investigated. Slurries of starch and theophylline were autoclaved in a polypropylene tablet mold and then stored at 4 °C or cycled at 4/30 °C for 8 days. By increasing the period of retrogradation at 4 °C the size of air cells in freeze-dried gels was decreased and the cell walls became thinner. Retrogradation reduced the pore size of the gels and hindered gel swelling in an amylase-containing dissolution medium. These effects became more significant with temperature cycles. The resistance to enzymatic erosion and decreased swelling by the retrogradation under 4/30 °C cycles resulted in a retarded release of theophylline. Thus, temperature-cycled retrogradation of a waxy maize starch gel provided a compact matrix structure that effectively retarded the drug release.
| Original language | English |
|---|---|
| Pages (from-to) | 449-453 |
| Number of pages | 5 |
| Journal | Carbohydrate Polymers |
| Volume | 76 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2009 Apr 9 |
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Keywords
- Gel
- Release
- Retrogradation
- Starch
- Tablet
- Theophylline
ASJC Scopus subject areas
- Organic Chemistry
- Materials Chemistry
- Polymers and Plastics
Cite this
Utilization of retrograded waxy maize starch gels as tablet matrix for controlled release of theophylline. / Yoon, H. S.; Lee, J. H.; Lim, Seung Taik.
In: Carbohydrate Polymers, Vol. 76, No. 3, 09.04.2009, p. 449-453.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Utilization of retrograded waxy maize starch gels as tablet matrix for controlled release of theophylline
AU - Yoon, H. S.
AU - Lee, J. H.
AU - Lim, Seung Taik
PY - 2009/4/9
Y1 - 2009/4/9
N2 - Theophylline tablets were prepared using waxy maize starch gels and the effect of retrogradation on the release of theophylline was investigated. Slurries of starch and theophylline were autoclaved in a polypropylene tablet mold and then stored at 4 °C or cycled at 4/30 °C for 8 days. By increasing the period of retrogradation at 4 °C the size of air cells in freeze-dried gels was decreased and the cell walls became thinner. Retrogradation reduced the pore size of the gels and hindered gel swelling in an amylase-containing dissolution medium. These effects became more significant with temperature cycles. The resistance to enzymatic erosion and decreased swelling by the retrogradation under 4/30 °C cycles resulted in a retarded release of theophylline. Thus, temperature-cycled retrogradation of a waxy maize starch gel provided a compact matrix structure that effectively retarded the drug release.
AB - Theophylline tablets were prepared using waxy maize starch gels and the effect of retrogradation on the release of theophylline was investigated. Slurries of starch and theophylline were autoclaved in a polypropylene tablet mold and then stored at 4 °C or cycled at 4/30 °C for 8 days. By increasing the period of retrogradation at 4 °C the size of air cells in freeze-dried gels was decreased and the cell walls became thinner. Retrogradation reduced the pore size of the gels and hindered gel swelling in an amylase-containing dissolution medium. These effects became more significant with temperature cycles. The resistance to enzymatic erosion and decreased swelling by the retrogradation under 4/30 °C cycles resulted in a retarded release of theophylline. Thus, temperature-cycled retrogradation of a waxy maize starch gel provided a compact matrix structure that effectively retarded the drug release.
KW - Gel
KW - Release
KW - Retrogradation
KW - Starch
KW - Tablet
KW - Theophylline
UR - http://www.scopus.com/inward/record.url?scp=62749181753&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=62749181753&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2008.11.011
DO - 10.1016/j.carbpol.2008.11.011
M3 - Article
AN - SCOPUS:62749181753
VL - 76
SP - 449
EP - 453
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
SN - 0144-8617
IS - 3
ER -