Uvulopalatopharyngoplasty may reduce the incidence of dementia caused by obstructive sleep apnea

National insurance service survey 2007-2014

Jae Hoon Cho, Jeffrey D. Suh, Kyung Do Han, Jin Hyung Jung, Heung Man Lee

Research output: Contribution to journalReview article

Abstract

Study Objectives: Numerous studies have found that obstructive sleep apnea (OSA) causes or exacerbates dementia, including Alzheimer disease and vascular dementia. However, the evidence is often conflicting. Moreover, no study has investigated the effect of surgical treatment for OSA on dementia. Methods: This retrospective cohort study analyzed data from the Korea National Health Insurance Corporation. A total of 125,417 participants (age 40 years or older) with a new diagnosis of OSA between 2007 and 2014 were included. The participants were classified into two groups: Those who underwent uvulopalatopharyngoplasty (UPPP group, n = 12,664) and those who underwent no surgical treatment (no surgery group, n = 112,753). Propensity score matching by age and sex was used to select the control group of 627,085 participants. Mean follow-up duration was 4.6 ± 2.3 years. The primary endpoint was newly diagnosed Alzheimer dementia, vascular dementia, or other types of dementia. Results: Compared with the control group, the hazard ratio (HR) and 95% confidence interval of dementia was calculated for patients with OSA. In the no-surgery group, the incidence of Alzheimer disease (HR 1.30 [1.22-1.38]), vascular dementia (HR 1.20 [1.05-1.36]), and other types of dementia (HR 1.35 [1.20-1.54]) was significantly higher than those among the control group. In the UPPP group, the incidence of Alzheimer disease (HR 1.08 [0.80-1.45]), vascular dementia (HR 0.58 [0.30-1.12]), and other types of dementia (HR 1.00 [0.57-1.77]) was similar to control levels. Conclusions: Uvulopalatopharyngoplasty may have a preventive effect on dementia in patients with OSA.

Original languageEnglish
Pages (from-to)1749-1755
Number of pages7
JournalJournal of Clinical Sleep Medicine
Volume14
Issue number10
DOIs
Publication statusPublished - 2018 Oct 15

Fingerprint

Obstructive Sleep Apnea
Insurance
Dementia
Vascular Dementia
Alzheimer Disease
Incidence
Control Groups
Propensity Score
National Health Programs
Korea
Surveys and Questionnaires
Cohort Studies
Retrospective Studies
Confidence Intervals
Therapeutics

Keywords

  • Alzheimer disease
  • Obstructive sleep apnea
  • Uvulopalatopharyngoplasty
  • Vascular dementia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology

Cite this

Uvulopalatopharyngoplasty may reduce the incidence of dementia caused by obstructive sleep apnea : National insurance service survey 2007-2014. / Cho, Jae Hoon; Suh, Jeffrey D.; Han, Kyung Do; Jung, Jin Hyung; Lee, Heung Man.

In: Journal of Clinical Sleep Medicine, Vol. 14, No. 10, 15.10.2018, p. 1749-1755.

Research output: Contribution to journalReview article

@article{c7da69bca4524d03b31addb9dd8c49a7,
title = "Uvulopalatopharyngoplasty may reduce the incidence of dementia caused by obstructive sleep apnea: National insurance service survey 2007-2014",
abstract = "Study Objectives: Numerous studies have found that obstructive sleep apnea (OSA) causes or exacerbates dementia, including Alzheimer disease and vascular dementia. However, the evidence is often conflicting. Moreover, no study has investigated the effect of surgical treatment for OSA on dementia. Methods: This retrospective cohort study analyzed data from the Korea National Health Insurance Corporation. A total of 125,417 participants (age 40 years or older) with a new diagnosis of OSA between 2007 and 2014 were included. The participants were classified into two groups: Those who underwent uvulopalatopharyngoplasty (UPPP group, n = 12,664) and those who underwent no surgical treatment (no surgery group, n = 112,753). Propensity score matching by age and sex was used to select the control group of 627,085 participants. Mean follow-up duration was 4.6 ± 2.3 years. The primary endpoint was newly diagnosed Alzheimer dementia, vascular dementia, or other types of dementia. Results: Compared with the control group, the hazard ratio (HR) and 95{\%} confidence interval of dementia was calculated for patients with OSA. In the no-surgery group, the incidence of Alzheimer disease (HR 1.30 [1.22-1.38]), vascular dementia (HR 1.20 [1.05-1.36]), and other types of dementia (HR 1.35 [1.20-1.54]) was significantly higher than those among the control group. In the UPPP group, the incidence of Alzheimer disease (HR 1.08 [0.80-1.45]), vascular dementia (HR 0.58 [0.30-1.12]), and other types of dementia (HR 1.00 [0.57-1.77]) was similar to control levels. Conclusions: Uvulopalatopharyngoplasty may have a preventive effect on dementia in patients with OSA.",
keywords = "Alzheimer disease, Obstructive sleep apnea, Uvulopalatopharyngoplasty, Vascular dementia",
author = "Cho, {Jae Hoon} and Suh, {Jeffrey D.} and Han, {Kyung Do} and Jung, {Jin Hyung} and Lee, {Heung Man}",
year = "2018",
month = "10",
day = "15",
doi = "10.5664/jcsm.7388",
language = "English",
volume = "14",
pages = "1749--1755",
journal = "Journal of Clinical Sleep Medicine",
issn = "1550-9389",
publisher = "American Academy of Sleep Medicine",
number = "10",

}

TY - JOUR

T1 - Uvulopalatopharyngoplasty may reduce the incidence of dementia caused by obstructive sleep apnea

T2 - National insurance service survey 2007-2014

AU - Cho, Jae Hoon

AU - Suh, Jeffrey D.

AU - Han, Kyung Do

AU - Jung, Jin Hyung

AU - Lee, Heung Man

PY - 2018/10/15

Y1 - 2018/10/15

N2 - Study Objectives: Numerous studies have found that obstructive sleep apnea (OSA) causes or exacerbates dementia, including Alzheimer disease and vascular dementia. However, the evidence is often conflicting. Moreover, no study has investigated the effect of surgical treatment for OSA on dementia. Methods: This retrospective cohort study analyzed data from the Korea National Health Insurance Corporation. A total of 125,417 participants (age 40 years or older) with a new diagnosis of OSA between 2007 and 2014 were included. The participants were classified into two groups: Those who underwent uvulopalatopharyngoplasty (UPPP group, n = 12,664) and those who underwent no surgical treatment (no surgery group, n = 112,753). Propensity score matching by age and sex was used to select the control group of 627,085 participants. Mean follow-up duration was 4.6 ± 2.3 years. The primary endpoint was newly diagnosed Alzheimer dementia, vascular dementia, or other types of dementia. Results: Compared with the control group, the hazard ratio (HR) and 95% confidence interval of dementia was calculated for patients with OSA. In the no-surgery group, the incidence of Alzheimer disease (HR 1.30 [1.22-1.38]), vascular dementia (HR 1.20 [1.05-1.36]), and other types of dementia (HR 1.35 [1.20-1.54]) was significantly higher than those among the control group. In the UPPP group, the incidence of Alzheimer disease (HR 1.08 [0.80-1.45]), vascular dementia (HR 0.58 [0.30-1.12]), and other types of dementia (HR 1.00 [0.57-1.77]) was similar to control levels. Conclusions: Uvulopalatopharyngoplasty may have a preventive effect on dementia in patients with OSA.

AB - Study Objectives: Numerous studies have found that obstructive sleep apnea (OSA) causes or exacerbates dementia, including Alzheimer disease and vascular dementia. However, the evidence is often conflicting. Moreover, no study has investigated the effect of surgical treatment for OSA on dementia. Methods: This retrospective cohort study analyzed data from the Korea National Health Insurance Corporation. A total of 125,417 participants (age 40 years or older) with a new diagnosis of OSA between 2007 and 2014 were included. The participants were classified into two groups: Those who underwent uvulopalatopharyngoplasty (UPPP group, n = 12,664) and those who underwent no surgical treatment (no surgery group, n = 112,753). Propensity score matching by age and sex was used to select the control group of 627,085 participants. Mean follow-up duration was 4.6 ± 2.3 years. The primary endpoint was newly diagnosed Alzheimer dementia, vascular dementia, or other types of dementia. Results: Compared with the control group, the hazard ratio (HR) and 95% confidence interval of dementia was calculated for patients with OSA. In the no-surgery group, the incidence of Alzheimer disease (HR 1.30 [1.22-1.38]), vascular dementia (HR 1.20 [1.05-1.36]), and other types of dementia (HR 1.35 [1.20-1.54]) was significantly higher than those among the control group. In the UPPP group, the incidence of Alzheimer disease (HR 1.08 [0.80-1.45]), vascular dementia (HR 0.58 [0.30-1.12]), and other types of dementia (HR 1.00 [0.57-1.77]) was similar to control levels. Conclusions: Uvulopalatopharyngoplasty may have a preventive effect on dementia in patients with OSA.

KW - Alzheimer disease

KW - Obstructive sleep apnea

KW - Uvulopalatopharyngoplasty

KW - Vascular dementia

UR - http://www.scopus.com/inward/record.url?scp=85055163186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055163186&partnerID=8YFLogxK

U2 - 10.5664/jcsm.7388

DO - 10.5664/jcsm.7388

M3 - Review article

VL - 14

SP - 1749

EP - 1755

JO - Journal of Clinical Sleep Medicine

JF - Journal of Clinical Sleep Medicine

SN - 1550-9389

IS - 10

ER -