Val158Met polymorphism in the catechol-O-methyltransferase (COMT) gene is not associated with tardive dyskinesia in schizophrenia

Seung Gul Kang, Jung Eun Choi, Young Min Park, Heon-Jeong Lee, Changsu Han, Yong Ku Kim, Seung Hyun Kim, Min-Soo Lee, Sook Haeng Joe, In Kwa Jung, Leen Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: This study investigated whether the catechol-O-methyltransferase (COMT) gene V158M single-nucleotide polymorphism (SNP) influences susceptibility to tardive dyskinesia (TD). Methods: We examined 209 Korean schizophrenic patients using the Abnormal Involuntary Movement Scale (AIMS), with genotyping performed for the COMT gene V158M SNP. Results: The logistic regression analysis showed that old age [p = 0.032, OR = 1.40 (OR corresponds to 10-year), 95% CI = 1.03-1.90] was a risk factor for TD, but there was no significant association between the COMT genotype and TD. The heterozygotes (MV genotype) of the COMT gene polymorphism tended to develop TD less than homozygotes (MM and VV); however, the risk did not reach statistical significance (p = 0.050, OR = 1.81, 95% CI = 1.00-3.29). Conclusions: These results suggest that the V158M SNP of the COMT gene is not associated with TD in schizophrenia. However, there is a tendency that the heterozygous genotype of the COMT gene polymorphism has a protective effect against TD. Further investigations are warranted to evaluate a molecular heterosis of this polymorphism in development of TD in a large sample of subjects.

Original languageEnglish
Pages (from-to)22-25
Number of pages4
JournalNeuropsychobiology
Volume57
Issue number1-2
DOIs
Publication statusPublished - 2008 Jun 1

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Catechol O-Methyltransferase
Schizophrenia
Genes
Single Nucleotide Polymorphism
Genotype
Hybrid Vigor
Homozygote
Heterozygote
Tardive Dyskinesia
Logistic Models
Regression Analysis

Keywords

  • Catechol-O-methyltransferase gene
  • Polymorphism
  • Schizophrenia
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Val158Met polymorphism in the catechol-O-methyltransferase (COMT) gene is not associated with tardive dyskinesia in schizophrenia. / Kang, Seung Gul; Choi, Jung Eun; Park, Young Min; Lee, Heon-Jeong; Han, Changsu; Kim, Yong Ku; Kim, Seung Hyun; Lee, Min-Soo; Joe, Sook Haeng; Jung, In Kwa; Kim, Leen.

In: Neuropsychobiology, Vol. 57, No. 1-2, 01.06.2008, p. 22-25.

Research output: Contribution to journalArticle

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abstract = "Objective: This study investigated whether the catechol-O-methyltransferase (COMT) gene V158M single-nucleotide polymorphism (SNP) influences susceptibility to tardive dyskinesia (TD). Methods: We examined 209 Korean schizophrenic patients using the Abnormal Involuntary Movement Scale (AIMS), with genotyping performed for the COMT gene V158M SNP. Results: The logistic regression analysis showed that old age [p = 0.032, OR = 1.40 (OR corresponds to 10-year), 95{\%} CI = 1.03-1.90] was a risk factor for TD, but there was no significant association between the COMT genotype and TD. The heterozygotes (MV genotype) of the COMT gene polymorphism tended to develop TD less than homozygotes (MM and VV); however, the risk did not reach statistical significance (p = 0.050, OR = 1.81, 95{\%} CI = 1.00-3.29). Conclusions: These results suggest that the V158M SNP of the COMT gene is not associated with TD in schizophrenia. However, there is a tendency that the heterozygous genotype of the COMT gene polymorphism has a protective effect against TD. Further investigations are warranted to evaluate a molecular heterosis of this polymorphism in development of TD in a large sample of subjects.",
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