Validation of Davson’s equation in patients suffering from idiopathic normal pressure hydrocephalus

Afroditi Despina Lalou, Virginia Levrini, Matthew Garnett, Eva Nabbanja, Dong Ju Kim, Laurent Gergele, Anna Bjornson, Zofia Czosnyka, Marek Czosnyka

Research output: Contribution to journalArticle

Abstract

Introduction: The so-called Davson’s equation relates baseline intracranial pressure (ICP) to resistance to cerebrospinal fluid outflow (Rout), formation of cerebrospinal fluid (If) and sagittal sinus pressure (PSS) There is a controversy over whether this fundamental equation is applicable in patients with normal pressure hydrocephalus (NPH). We investigated the relationship between Rout and ICP and also other compensatory, clinical and demographic parameters in NPH patients. Method: We carried out a retrospective study of 229 patients with primary NPH who had undergone constant-rate infusion studies in our hospital. Data was recorded and processed using ICM+ software. Relationships between variables were sought by calculating Pearson product correlation coefficients and p values. Results: We found a significant, albeit weak, relationship between ICP and Rout (R = 0.17, p = 0.0049), Rout and peak-to-peak amplitude of ICP (AMP) (R = 0.27, p = 3.577e-05) and Rout and age (R = 0.16, p = 0.01306). Conclusions: The relationship found between ICP and Rout provides indirect evidence to support disturbed Cerebrospinal fluid circulation as a key factor in disturbed CSF dynamics in NPH. Weak correlation may indicate that other factors—variable PSS and formation of CSF outflow—contribute heavily to linear model expressed by Davson’s equation.

Original languageEnglish
Pages (from-to)1097-1103
Number of pages7
JournalActa Neurochirurgica
Volume160
Issue number5
DOIs
Publication statusPublished - 2018 May 1

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Normal Pressure Hydrocephalus
Intracranial Pressure
Cerebrospinal Fluid
Pressure
Linear Models
Software
Retrospective Studies
Demography

Keywords

  • Davson’s equation
  • Intracranial pressure
  • Normal pressure hydrocephalus
  • Resistance to CSF outflow

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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Validation of Davson’s equation in patients suffering from idiopathic normal pressure hydrocephalus. / Lalou, Afroditi Despina; Levrini, Virginia; Garnett, Matthew; Nabbanja, Eva; Kim, Dong Ju; Gergele, Laurent; Bjornson, Anna; Czosnyka, Zofia; Czosnyka, Marek.

In: Acta Neurochirurgica, Vol. 160, No. 5, 01.05.2018, p. 1097-1103.

Research output: Contribution to journalArticle

Lalou, AD, Levrini, V, Garnett, M, Nabbanja, E, Kim, DJ, Gergele, L, Bjornson, A, Czosnyka, Z & Czosnyka, M 2018, 'Validation of Davson’s equation in patients suffering from idiopathic normal pressure hydrocephalus', Acta Neurochirurgica, vol. 160, no. 5, pp. 1097-1103. https://doi.org/10.1007/s00701-018-3497-9
Lalou, Afroditi Despina ; Levrini, Virginia ; Garnett, Matthew ; Nabbanja, Eva ; Kim, Dong Ju ; Gergele, Laurent ; Bjornson, Anna ; Czosnyka, Zofia ; Czosnyka, Marek. / Validation of Davson’s equation in patients suffering from idiopathic normal pressure hydrocephalus. In: Acta Neurochirurgica. 2018 ; Vol. 160, No. 5. pp. 1097-1103.
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