Validation of SAPS3 admission score and its customization for use in Korean intensive care unit patients

A prospective multicentre study

So Yeon Lim, Shin Ok Koh, Kyeongman Jeon, Sungwon Na, Chae Man Lim, Won Il Choi, Young Joo Lee, Seok Chan Kim, Gyu Rak Chon, Je Hyeong Kim, Jae Yeol Kim, Jaemin Lim, Chin Kook Rhee, Sunghoon Park, Ho Cheol Kim, Jin Hwa Lee, Ji Hyun Lee, Jisook Park, Younsuck Koh, Gee Young Suh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background and objective To externally validate the simplified acute physiology score 3 (SAPS3) and to customize it for use in Korean intensive care unit (ICU) patients. Methods This is a prospective multicentre cohort study involving 22 ICUs from 15 centres throughout Korea. The study population comprised patients who were consecutively admitted to participating ICUs from 1 July 2010 to 31 January 2011. Results A total of 4617 patients were enrolled. ICU mortality was 14.3%, and hospital mortality was 20.6%. The patients were randomly assigned into one of two cohorts: a development (n = 2309) or validation (n = 2308) cohort. In the development cohort, the general SAPS3 had good discrimination (area under the receiver operating characteristics curve = 0.829), but poor calibration (Hosmer-Lemeshow goodness-of-fit test H = 123.06, P < 0.001, C = 118.45, P < 0.001). The Australasia SAPS3 did not improve calibration (H = 73.53, P < 0.001, C = 70.52, P < 0.001). Customization was achieved by altering the logit of the original SAPS3 equation. The new equation for Korean ICU patients was validated in the validation cohort, and demonstrated both good discrimination (area under the receiver operating characteristics curve = 0.835) and good calibration (H = 4.61, P = 0.799, C = 5.67, P = 0.684). Conclusions General and regional Australasia SAPS3 admission scores showed poor calibration for use in Korean ICU patients, but the prognostic power of the SAPS3 was significantly improved by customization. Prediction models should be customized before being used to predict mortality in different regions of the world. We investigated to validate the simplified acute physiology score 3 (SAPS3) and to customize it in Korean ICUs. General and Australasia SAPS3 showed poor calibration, but the prognostic power was improved by customization. Prediction models should be customized before being used to predict mortality in different regions.

Original languageEnglish
Pages (from-to)989-995
Number of pages7
JournalRespirology
Volume18
Issue number6
DOIs
Publication statusPublished - 2013 Aug 1

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Multicenter Studies
Intensive Care Units
Prospective Studies
Calibration
Australasia
ROC Curve
Mortality
Simplified Acute Physiology Score
Korea
Hospital Mortality
Cohort Studies
Population

Keywords

  • calibration
  • discrimination
  • intensive care unit
  • severity of illness

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Validation of SAPS3 admission score and its customization for use in Korean intensive care unit patients : A prospective multicentre study. / Lim, So Yeon; Koh, Shin Ok; Jeon, Kyeongman; Na, Sungwon; Lim, Chae Man; Choi, Won Il; Lee, Young Joo; Kim, Seok Chan; Chon, Gyu Rak; Kim, Je Hyeong; Kim, Jae Yeol; Lim, Jaemin; Rhee, Chin Kook; Park, Sunghoon; Kim, Ho Cheol; Lee, Jin Hwa; Lee, Ji Hyun; Park, Jisook; Koh, Younsuck; Suh, Gee Young.

In: Respirology, Vol. 18, No. 6, 01.08.2013, p. 989-995.

Research output: Contribution to journalArticle

Lim, SY, Koh, SO, Jeon, K, Na, S, Lim, CM, Choi, WI, Lee, YJ, Kim, SC, Chon, GR, Kim, JH, Kim, JY, Lim, J, Rhee, CK, Park, S, Kim, HC, Lee, JH, Lee, JH, Park, J, Koh, Y & Suh, GY 2013, 'Validation of SAPS3 admission score and its customization for use in Korean intensive care unit patients: A prospective multicentre study', Respirology, vol. 18, no. 6, pp. 989-995. https://doi.org/10.1111/resp.12115
Lim, So Yeon ; Koh, Shin Ok ; Jeon, Kyeongman ; Na, Sungwon ; Lim, Chae Man ; Choi, Won Il ; Lee, Young Joo ; Kim, Seok Chan ; Chon, Gyu Rak ; Kim, Je Hyeong ; Kim, Jae Yeol ; Lim, Jaemin ; Rhee, Chin Kook ; Park, Sunghoon ; Kim, Ho Cheol ; Lee, Jin Hwa ; Lee, Ji Hyun ; Park, Jisook ; Koh, Younsuck ; Suh, Gee Young. / Validation of SAPS3 admission score and its customization for use in Korean intensive care unit patients : A prospective multicentre study. In: Respirology. 2013 ; Vol. 18, No. 6. pp. 989-995.
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T2 - A prospective multicentre study

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AU - Koh, Shin Ok

AU - Jeon, Kyeongman

AU - Na, Sungwon

AU - Lim, Chae Man

AU - Choi, Won Il

AU - Lee, Young Joo

AU - Kim, Seok Chan

AU - Chon, Gyu Rak

AU - Kim, Je Hyeong

AU - Kim, Jae Yeol

AU - Lim, Jaemin

AU - Rhee, Chin Kook

AU - Park, Sunghoon

AU - Kim, Ho Cheol

AU - Lee, Jin Hwa

AU - Lee, Ji Hyun

AU - Park, Jisook

AU - Koh, Younsuck

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