Validation of the classification criteria commonly used in Korea and a modified set of preliminary criteria for Behçet's disease: A multi-center study

Hyun Kyu Chang, Shin Seok Lee, Hyun Joo Bai, Yyun Woo Lee, Bo Young Yoon, Chan Hee Lee, Young Ho Lee, Gwan Gyu Song, Won Tae Chung, Sung Won Lee, Jung Yoon Choe, Chae Gi Kim, Dae Kook Chang

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18 Citations (Scopus)

Abstract

Objective. Recently we have proposed a modified set of criteria to settle the questions raised regarding the International Study Group (ISG) criteria for Behçet's disease (BD). The aim of the present study was to validate the two pre-existing criteria sets commonly used in Korea, the ISG criteria and the criteria of the Behçet's Disease Research Committee of Japan (Japanese criteria), as well as the proposed modified criteria. Methods. The study population included 155 consecutive patients with BD and 170 controls with non-Behçet's rheumatic diseases. Detailed data for all of the subjects were recorded prospectively by the participating physicians on a standard form that listed the clinical features of BD. The sensitivity, specificity, and accuracy of each set of the criteria were measured. Results. Of the three criteria sets employed, the modified criteria were the most accurate, with an accuracy of 96.3%. The ISG criteria often failed to classify the following patients with BD: patients with only oral and genital ulcerations, certain patients with intestinal ulcerations, patients who did not manifest oral ulcerations, and patients with acute disease but fewer than three recurrent oral ulceration relapses in a 1-year period. The Japanese criteria also failed to categorize the following patients with BD: patients with oral and genital ulcerations, and patients with oral ulcerations, skin lesions, and a positive pathergy reaction. In addition, the Japanese criteria misclassified some of the control subjects with non-Behçet's uveitis as having BD. Conclusions. The results of this study suggest that there are some points that need to be reconsidered in the clinical application of the two pre-existing sets of criteria. Although the modified criteria were the most accurate, further validation studies will be required in other ethnic populations.

Original languageEnglish
Pages (from-to)S21-S26
JournalClinical and experimental rheumatology
Volume22
Issue number4 SUPPL. 24
Publication statusPublished - 2004

Keywords

  • Behçet's disease
  • Criteria
  • Validation

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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    Chang, H. K., Lee, S. S., Bai, H. J., Lee, Y. W., Yoon, B. Y., Lee, C. H., Lee, Y. H., Song, G. G., Chung, W. T., Lee, S. W., Choe, J. Y., Kim, C. G., & Chang, D. K. (2004). Validation of the classification criteria commonly used in Korea and a modified set of preliminary criteria for Behçet's disease: A multi-center study. Clinical and experimental rheumatology, 22(4 SUPPL. 24), S21-S26.