Validity of the specialized columnar epithelium as a diagnostic criterion of the short segment Barrett's esophagus.

Young-Tae Bak, G. M. Jung, Jong Eun Yeon, J. S. Kim, Kwan Soo Byun, J. H. Kim, J. G. Kim, C. H. Lee, H. K. Kim, N. H. Won

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

OBJECTIVE: In the areas where intestinal metaplasia of the stomach is highly prevalent, diagnosing Barrett's esophagus solely by the presence of specialized columnar epithelium in the distal esophagus may lead to many false positive diagnoses. The aim of this study was to test validity of the specialized columnar epithelium as a diagnostic criterion of the short segment Barrett's esophagus in Korea. METHODS: During routine gastroscopy, the length of columnar-lined esophagus was measured and biopsy samples were taken from the mucosa immediately distal to the squamocolumnar junction. Under light microscopy, alcian blue-positive cells were identified. RESULTS: Prevalence of the specialized columnar epithelium in cases without the columnar-lined esophagus and with the short segment columnar-lined esophagus were 57.1% and 31.2%, respectively (P = 0.0281). The specialized columnar epithelium is frequently seen around the cardia in Koreans with or without the columnar-lined esophagus. CONCLUSION: Simple presence of the specialized columnar epithelium is not a valid criterion for a diagnosis of Barrett's esophagus. We propose that both the short segment Barrett's esophagus and the goblet cell metaplasia of the cardia might be grouped together under a title of "the specialized columnar epithelium around the gastroesophageal junction" as a potential preceding condition of adenocarcinoma around the cardia.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalThe Korean journal of internal medicine
Volume13
Issue number2
DOIs
Publication statusPublished - 1998 Jan 1

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Barrett Esophagus
Epithelium
Esophagus
Cardia
Metaplasia
Esophagogastric Junction
Gastroscopy
Alcian Blue
Goblet Cells
Korea
Microscopy
Stomach
Mucous Membrane
Adenocarcinoma
Biopsy
Light

ASJC Scopus subject areas

  • Internal Medicine

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Validity of the specialized columnar epithelium as a diagnostic criterion of the short segment Barrett's esophagus. / Bak, Young-Tae; Jung, G. M.; Yeon, Jong Eun; Kim, J. S.; Byun, Kwan Soo; Kim, J. H.; Kim, J. G.; Lee, C. H.; Kim, H. K.; Won, N. H.

In: The Korean journal of internal medicine, Vol. 13, No. 2, 01.01.1998, p. 99-103.

Research output: Contribution to journalArticle

Bak, Young-Tae ; Jung, G. M. ; Yeon, Jong Eun ; Kim, J. S. ; Byun, Kwan Soo ; Kim, J. H. ; Kim, J. G. ; Lee, C. H. ; Kim, H. K. ; Won, N. H. / Validity of the specialized columnar epithelium as a diagnostic criterion of the short segment Barrett's esophagus. In: The Korean journal of internal medicine. 1998 ; Vol. 13, No. 2. pp. 99-103.
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abstract = "OBJECTIVE: In the areas where intestinal metaplasia of the stomach is highly prevalent, diagnosing Barrett's esophagus solely by the presence of specialized columnar epithelium in the distal esophagus may lead to many false positive diagnoses. The aim of this study was to test validity of the specialized columnar epithelium as a diagnostic criterion of the short segment Barrett's esophagus in Korea. METHODS: During routine gastroscopy, the length of columnar-lined esophagus was measured and biopsy samples were taken from the mucosa immediately distal to the squamocolumnar junction. Under light microscopy, alcian blue-positive cells were identified. RESULTS: Prevalence of the specialized columnar epithelium in cases without the columnar-lined esophagus and with the short segment columnar-lined esophagus were 57.1{\%} and 31.2{\%}, respectively (P = 0.0281). The specialized columnar epithelium is frequently seen around the cardia in Koreans with or without the columnar-lined esophagus. CONCLUSION: Simple presence of the specialized columnar epithelium is not a valid criterion for a diagnosis of Barrett's esophagus. We propose that both the short segment Barrett's esophagus and the goblet cell metaplasia of the cardia might be grouped together under a title of {"}the specialized columnar epithelium around the gastroesophageal junction{"} as a potential preceding condition of adenocarcinoma around the cardia.",
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AU - Byun, Kwan Soo

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