TY - JOUR
T1 - Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain
AU - Jeon, Gye Sun
AU - Park, Sang Ha
AU - Lee, Kuem Ju
AU - Lee, Min Soo
AU - Chun, Boe Gwun
AU - Shin, Kyung Ho
N1 - Funding Information:
This research was supported by a grant from the Brain Research Center of the 21st Century Frontier Research Program, funded by the Korean Ministry of Science and Technology (M103KV010007-03K2201-00720), Brain Korea 21 Project in 2006 and Korea Health 21 R&D Project (KPGRN-R-04-04) by the Ministry of Health and Welfare, Republic of Korea.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/9/18
Y1 - 2006/9/18
N2 - To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. MK801 significantly increased BDNF expression in the retrosplenial and entorhinal cortex, and these increases were prevented by valproate pretreatment. Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. These results indicate that valproate pretreatment differentially affects the MK801-induced changes in BDNF expression in a region-selective manner.
AB - To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. MK801 significantly increased BDNF expression in the retrosplenial and entorhinal cortex, and these increases were prevented by valproate pretreatment. Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. These results indicate that valproate pretreatment differentially affects the MK801-induced changes in BDNF expression in a region-selective manner.
KW - BDNF (brain-derived neurotrophic factor)
KW - MK801
KW - Retrosplenial cortex
KW - Valproate
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U2 - 10.1016/j.ejphar.2006.06.046
DO - 10.1016/j.ejphar.2006.06.046
M3 - Article
C2 - 16884712
AN - SCOPUS:33747368890
VL - 545
SP - 142
EP - 146
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2-3
ER -