Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain

Gye Sun Jeon, Sang Ha Park, Kuem Ju Lee, Min Soo Lee, Boe Gwun Chun, Kyung Ho Shin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. MK801 significantly increased BDNF expression in the retrosplenial and entorhinal cortex, and these increases were prevented by valproate pretreatment. Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. These results indicate that valproate pretreatment differentially affects the MK801-induced changes in BDNF expression in a region-selective manner.

Original languageEnglish
Pages (from-to)142-146
Number of pages5
JournalEuropean Journal of Pharmacology
Volume545
Issue number2-3
DOIs
Publication statusPublished - 2006 Sep 18

Keywords

  • BDNF (brain-derived neurotrophic factor)
  • MK801
  • Retrosplenial cortex
  • Valproate

ASJC Scopus subject areas

  • Pharmacology

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