Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain

Gye Sun Jeon, Sang Ha Park, Kuem Ju Lee, Min-Soo Lee, Boe Gwun Chun, Kyung-Ho Shin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. MK801 significantly increased BDNF expression in the retrosplenial and entorhinal cortex, and these increases were prevented by valproate pretreatment. Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. These results indicate that valproate pretreatment differentially affects the MK801-induced changes in BDNF expression in a region-selective manner.

Original languageEnglish
Pages (from-to)142-146
Number of pages5
JournalEuropean Journal of Pharmacology
Volume545
Issue number2-3
DOIs
Publication statusPublished - 2006 Sep 18

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Brain-Derived Neurotrophic Factor
Valproic Acid
Messenger RNA
Brain
Entorhinal Cortex
Anticonvulsants
Hippocampus
Injections

Keywords

  • BDNF (brain-derived neurotrophic factor)
  • MK801
  • Retrosplenial cortex
  • Valproate

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain. / Jeon, Gye Sun; Park, Sang Ha; Lee, Kuem Ju; Lee, Min-Soo; Chun, Boe Gwun; Shin, Kyung-Ho.

In: European Journal of Pharmacology, Vol. 545, No. 2-3, 18.09.2006, p. 142-146.

Research output: Contribution to journalArticle

Jeon, Gye Sun ; Park, Sang Ha ; Lee, Kuem Ju ; Lee, Min-Soo ; Chun, Boe Gwun ; Shin, Kyung-Ho. / Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain. In: European Journal of Pharmacology. 2006 ; Vol. 545, No. 2-3. pp. 142-146.
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