Abstract
To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. MK801 significantly increased BDNF expression in the retrosplenial and entorhinal cortex, and these increases were prevented by valproate pretreatment. Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. These results indicate that valproate pretreatment differentially affects the MK801-induced changes in BDNF expression in a region-selective manner.
| Original language | English |
|---|---|
| Pages (from-to) | 142-146 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 545 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 2006 Sep 18 |
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Keywords
- BDNF (brain-derived neurotrophic factor)
- MK801
- Retrosplenial cortex
- Valproate
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain. / Jeon, Gye Sun; Park, Sang Ha; Lee, Kuem Ju; Lee, Min-Soo; Chun, Boe Gwun; Shin, Kyung-Ho.
In: European Journal of Pharmacology, Vol. 545, No. 2-3, 18.09.2006, p. 142-146.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain
AU - Jeon, Gye Sun
AU - Park, Sang Ha
AU - Lee, Kuem Ju
AU - Lee, Min-Soo
AU - Chun, Boe Gwun
AU - Shin, Kyung-Ho
PY - 2006/9/18
Y1 - 2006/9/18
N2 - To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. MK801 significantly increased BDNF expression in the retrosplenial and entorhinal cortex, and these increases were prevented by valproate pretreatment. Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. These results indicate that valproate pretreatment differentially affects the MK801-induced changes in BDNF expression in a region-selective manner.
AB - To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. MK801 significantly increased BDNF expression in the retrosplenial and entorhinal cortex, and these increases were prevented by valproate pretreatment. Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. These results indicate that valproate pretreatment differentially affects the MK801-induced changes in BDNF expression in a region-selective manner.
KW - BDNF (brain-derived neurotrophic factor)
KW - MK801
KW - Retrosplenial cortex
KW - Valproate
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UR - http://www.scopus.com/inward/citedby.url?scp=33747368890&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2006.06.046
DO - 10.1016/j.ejphar.2006.06.046
M3 - Article
VL - 545
SP - 142
EP - 146
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2-3
ER -