Value of early check-up of carbohydrate antigen 19-9 levels for pancreatic cancer screening in asymptomatic new-onset diabetic patients

Jung Wan Choe, Jae Seon Kim, Hyo Jung Kim, Soon Young Hwang, Moon Kyung Joo, Beomjae Lee, Ji Hoon Kim, Jong Eun Yeon, Jong Jae Park, Kwan Soo Byun, Young-Tae Bak

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives: We evaluated the value of carbohydrate antigen 19-9 (CA 19-9) as a pancreatic cancer (PC) screening tool in an asymptomatic new-onset diabetic patients. Methods: Medical records of asymptomatic patients newly diagnosed with diabetes mellitus (DM) were reviewed retrospectively at our hospital from January 2004 to January 2013. Results: In total, 2363 asymptomatic diabetic patientswith CA19-9measurements were enrolled. Of them, 68 (2.9%) were diagnosed with PC. In the 1719 patients who had CA 19-9 measured within 1 year after the DM diagnosis, a total of 51 (3.0 %) patients developed PC and the odds ratio (OR) of PC according to higher CA 19-9 than normal upper limit, 37 IU/mL was 5.57 (P < 0.001). In 248 patients checked CA 19-9 between 1 and 2 years after DM diagnosis, PC was detected in 9 (3.6%) cases and OR of high CA 19-9 was 4.51 (P = 0.019). However, beyond 2 years, the OR for PC showed no statistical significance. The patients with high CA 19-9 levels tended to have more advanced-stage disease. Conclusions: Early check-up of CA 19-9 could be a useful marker for screening for PC in asymptomatic patients with new-onset DM in the first 2 years.

Original languageEnglish
Pages (from-to)730-734
Number of pages5
JournalPancreas
Volume45
Issue number5
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • CA 19-9 antigen
  • Diabetes mellitus
  • Early detection of cancer
  • Pancreatic neoplasms

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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  • Cite this

    Choe, J. W., Kim, J. S., Kim, H. J., Hwang, S. Y., Joo, M. K., Lee, B., Kim, J. H., Yeon, J. E., Park, J. J., Byun, K. S., & Bak, Y-T. (2016). Value of early check-up of carbohydrate antigen 19-9 levels for pancreatic cancer screening in asymptomatic new-onset diabetic patients. Pancreas, 45(5), 730-734. https://doi.org/10.1097/MPA.0000000000000538