Value of early check-up of carbohydrate antigen 19-9 levels for pancreatic cancer screening in asymptomatic new-onset diabetic patients

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5 Citations (Scopus)

Abstract

Objectives: We evaluated the value of carbohydrate antigen 19-9 (CA 19-9) as a pancreatic cancer (PC) screening tool in an asymptomatic new-onset diabetic patients. Methods: Medical records of asymptomatic patients newly diagnosed with diabetes mellitus (DM) were reviewed retrospectively at our hospital from January 2004 to January 2013. Results: In total, 2363 asymptomatic diabetic patientswith CA19-9measurements were enrolled. Of them, 68 (2.9%) were diagnosed with PC. In the 1719 patients who had CA 19-9 measured within 1 year after the DM diagnosis, a total of 51 (3.0 %) patients developed PC and the odds ratio (OR) of PC according to higher CA 19-9 than normal upper limit, 37 IU/mL was 5.57 (P < 0.001). In 248 patients checked CA 19-9 between 1 and 2 years after DM diagnosis, PC was detected in 9 (3.6%) cases and OR of high CA 19-9 was 4.51 (P = 0.019). However, beyond 2 years, the OR for PC showed no statistical significance. The patients with high CA 19-9 levels tended to have more advanced-stage disease. Conclusions: Early check-up of CA 19-9 could be a useful marker for screening for PC in asymptomatic patients with new-onset DM in the first 2 years.

Original languageEnglish
Pages (from-to)730-734
Number of pages5
JournalPancreas
Volume45
Issue number5
DOIs
Publication statusPublished - 2016 Jan 1

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Pancreatic Neoplasms
Early Detection of Cancer
Carbohydrates
Antigens
Diabetes Mellitus
Odds Ratio
Medical Records

Keywords

  • CA 19-9 antigen
  • Diabetes mellitus
  • Early detection of cancer
  • Pancreatic neoplasms

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

@article{12e0c1ad34da4b0d8e8632f3f0625f8c,
title = "Value of early check-up of carbohydrate antigen 19-9 levels for pancreatic cancer screening in asymptomatic new-onset diabetic patients",
abstract = "Objectives: We evaluated the value of carbohydrate antigen 19-9 (CA 19-9) as a pancreatic cancer (PC) screening tool in an asymptomatic new-onset diabetic patients. Methods: Medical records of asymptomatic patients newly diagnosed with diabetes mellitus (DM) were reviewed retrospectively at our hospital from January 2004 to January 2013. Results: In total, 2363 asymptomatic diabetic patientswith CA19-9measurements were enrolled. Of them, 68 (2.9{\%}) were diagnosed with PC. In the 1719 patients who had CA 19-9 measured within 1 year after the DM diagnosis, a total of 51 (3.0 {\%}) patients developed PC and the odds ratio (OR) of PC according to higher CA 19-9 than normal upper limit, 37 IU/mL was 5.57 (P < 0.001). In 248 patients checked CA 19-9 between 1 and 2 years after DM diagnosis, PC was detected in 9 (3.6{\%}) cases and OR of high CA 19-9 was 4.51 (P = 0.019). However, beyond 2 years, the OR for PC showed no statistical significance. The patients with high CA 19-9 levels tended to have more advanced-stage disease. Conclusions: Early check-up of CA 19-9 could be a useful marker for screening for PC in asymptomatic patients with new-onset DM in the first 2 years.",
keywords = "CA 19-9 antigen, Diabetes mellitus, Early detection of cancer, Pancreatic neoplasms",
author = "Choe, {Jung Wan} and Kim, {Jae Seon} and Kim, {Hyo Jung} and Hwang, {Soon Young} and Joo, {Moon Kyung} and Beomjae Lee and Kim, {Ji Hoon} and Yeon, {Jong Eun} and Park, {Jong Jae} and Byun, {Kwan Soo} and Young-Tae Bak",
year = "2016",
month = "1",
day = "1",
doi = "10.1097/MPA.0000000000000538",
language = "English",
volume = "45",
pages = "730--734",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
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}

TY - JOUR

T1 - Value of early check-up of carbohydrate antigen 19-9 levels for pancreatic cancer screening in asymptomatic new-onset diabetic patients

AU - Choe, Jung Wan

AU - Kim, Jae Seon

AU - Kim, Hyo Jung

AU - Hwang, Soon Young

AU - Joo, Moon Kyung

AU - Lee, Beomjae

AU - Kim, Ji Hoon

AU - Yeon, Jong Eun

AU - Park, Jong Jae

AU - Byun, Kwan Soo

AU - Bak, Young-Tae

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Objectives: We evaluated the value of carbohydrate antigen 19-9 (CA 19-9) as a pancreatic cancer (PC) screening tool in an asymptomatic new-onset diabetic patients. Methods: Medical records of asymptomatic patients newly diagnosed with diabetes mellitus (DM) were reviewed retrospectively at our hospital from January 2004 to January 2013. Results: In total, 2363 asymptomatic diabetic patientswith CA19-9measurements were enrolled. Of them, 68 (2.9%) were diagnosed with PC. In the 1719 patients who had CA 19-9 measured within 1 year after the DM diagnosis, a total of 51 (3.0 %) patients developed PC and the odds ratio (OR) of PC according to higher CA 19-9 than normal upper limit, 37 IU/mL was 5.57 (P < 0.001). In 248 patients checked CA 19-9 between 1 and 2 years after DM diagnosis, PC was detected in 9 (3.6%) cases and OR of high CA 19-9 was 4.51 (P = 0.019). However, beyond 2 years, the OR for PC showed no statistical significance. The patients with high CA 19-9 levels tended to have more advanced-stage disease. Conclusions: Early check-up of CA 19-9 could be a useful marker for screening for PC in asymptomatic patients with new-onset DM in the first 2 years.

AB - Objectives: We evaluated the value of carbohydrate antigen 19-9 (CA 19-9) as a pancreatic cancer (PC) screening tool in an asymptomatic new-onset diabetic patients. Methods: Medical records of asymptomatic patients newly diagnosed with diabetes mellitus (DM) were reviewed retrospectively at our hospital from January 2004 to January 2013. Results: In total, 2363 asymptomatic diabetic patientswith CA19-9measurements were enrolled. Of them, 68 (2.9%) were diagnosed with PC. In the 1719 patients who had CA 19-9 measured within 1 year after the DM diagnosis, a total of 51 (3.0 %) patients developed PC and the odds ratio (OR) of PC according to higher CA 19-9 than normal upper limit, 37 IU/mL was 5.57 (P < 0.001). In 248 patients checked CA 19-9 between 1 and 2 years after DM diagnosis, PC was detected in 9 (3.6%) cases and OR of high CA 19-9 was 4.51 (P = 0.019). However, beyond 2 years, the OR for PC showed no statistical significance. The patients with high CA 19-9 levels tended to have more advanced-stage disease. Conclusions: Early check-up of CA 19-9 could be a useful marker for screening for PC in asymptomatic patients with new-onset DM in the first 2 years.

KW - CA 19-9 antigen

KW - Diabetes mellitus

KW - Early detection of cancer

KW - Pancreatic neoplasms

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