Value of external irradiation for locally advanced papillary thyroid cancer

Tae Hyun Kim, Dae-Sik Yang, Kwang-Yoon Jung, Chul Yong Kim, Myung Sun Choi

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Purpose: To look for the possible efficacy of external beam irradiation (EBRT) for locally advanced papillary thyroid cancers Methods and Materials: Between August 1981 and September 1997, 91 patients with locally advanced papillary thyroid cancers (pathologic Stage T4 or N1) were treated with surgical resection. After surgery, 23 patients received postoperative EBRT with or without ablative radioiodine therapy, and 68 patients were treated with ablative radioiodine therapy alone. The distribution of age, gender, and stage was comparable in both groups. Results: The overall survival rates at 7 years were not significantly different statistically between the two groups at 98.1% for the no-EBRT group and 90% for the EBRT group (p = 0.506). The locoregional control rates at 5 years were significantly different (EBRT 95.2% and no EBRT 67.5%; p = 0.0408). Analysis of the prognostic factors, age, gender, stage, and use of radioiodine ablative therapy, indicated these were not significant variables, except for EBRT. Conclusion: Adjuvant postoperative EBRT did not affect overall survival, but significantly improved locoregional control in patients with locally advanced papillary thyroid cancer (Stage pT4 or lymph node involvement).

Original languageEnglish
Pages (from-to)1006-1012
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume55
Issue number4
DOIs
Publication statusPublished - 2003 Mar 15

Fingerprint

cancer
irradiation
therapy
Age Distribution
age factor
Therapeutics
Survival Rate
Lymph Nodes
Survival
Papillary Thyroid cancer
lymphatic system
surgery

Keywords

  • External beam radiotherapy
  • Locoregional control
  • Papillary thyroid carcinoma

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Value of external irradiation for locally advanced papillary thyroid cancer. / Kim, Tae Hyun; Yang, Dae-Sik; Jung, Kwang-Yoon; Kim, Chul Yong; Choi, Myung Sun.

In: International Journal of Radiation Oncology Biology Physics, Vol. 55, No. 4, 15.03.2003, p. 1006-1012.

Research output: Contribution to journalArticle

@article{fbd64b19ea4646139be4febe49ca05b5,
title = "Value of external irradiation for locally advanced papillary thyroid cancer",
abstract = "Purpose: To look for the possible efficacy of external beam irradiation (EBRT) for locally advanced papillary thyroid cancers Methods and Materials: Between August 1981 and September 1997, 91 patients with locally advanced papillary thyroid cancers (pathologic Stage T4 or N1) were treated with surgical resection. After surgery, 23 patients received postoperative EBRT with or without ablative radioiodine therapy, and 68 patients were treated with ablative radioiodine therapy alone. The distribution of age, gender, and stage was comparable in both groups. Results: The overall survival rates at 7 years were not significantly different statistically between the two groups at 98.1{\%} for the no-EBRT group and 90{\%} for the EBRT group (p = 0.506). The locoregional control rates at 5 years were significantly different (EBRT 95.2{\%} and no EBRT 67.5{\%}; p = 0.0408). Analysis of the prognostic factors, age, gender, stage, and use of radioiodine ablative therapy, indicated these were not significant variables, except for EBRT. Conclusion: Adjuvant postoperative EBRT did not affect overall survival, but significantly improved locoregional control in patients with locally advanced papillary thyroid cancer (Stage pT4 or lymph node involvement).",
keywords = "External beam radiotherapy, Locoregional control, Papillary thyroid carcinoma",
author = "Kim, {Tae Hyun} and Dae-Sik Yang and Kwang-Yoon Jung and Kim, {Chul Yong} and Choi, {Myung Sun}",
year = "2003",
month = "3",
day = "15",
doi = "10.1016/S0360-3016(02)04203-7",
language = "English",
volume = "55",
pages = "1006--1012",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Value of external irradiation for locally advanced papillary thyroid cancer

AU - Kim, Tae Hyun

AU - Yang, Dae-Sik

AU - Jung, Kwang-Yoon

AU - Kim, Chul Yong

AU - Choi, Myung Sun

PY - 2003/3/15

Y1 - 2003/3/15

N2 - Purpose: To look for the possible efficacy of external beam irradiation (EBRT) for locally advanced papillary thyroid cancers Methods and Materials: Between August 1981 and September 1997, 91 patients with locally advanced papillary thyroid cancers (pathologic Stage T4 or N1) were treated with surgical resection. After surgery, 23 patients received postoperative EBRT with or without ablative radioiodine therapy, and 68 patients were treated with ablative radioiodine therapy alone. The distribution of age, gender, and stage was comparable in both groups. Results: The overall survival rates at 7 years were not significantly different statistically between the two groups at 98.1% for the no-EBRT group and 90% for the EBRT group (p = 0.506). The locoregional control rates at 5 years were significantly different (EBRT 95.2% and no EBRT 67.5%; p = 0.0408). Analysis of the prognostic factors, age, gender, stage, and use of radioiodine ablative therapy, indicated these were not significant variables, except for EBRT. Conclusion: Adjuvant postoperative EBRT did not affect overall survival, but significantly improved locoregional control in patients with locally advanced papillary thyroid cancer (Stage pT4 or lymph node involvement).

AB - Purpose: To look for the possible efficacy of external beam irradiation (EBRT) for locally advanced papillary thyroid cancers Methods and Materials: Between August 1981 and September 1997, 91 patients with locally advanced papillary thyroid cancers (pathologic Stage T4 or N1) were treated with surgical resection. After surgery, 23 patients received postoperative EBRT with or without ablative radioiodine therapy, and 68 patients were treated with ablative radioiodine therapy alone. The distribution of age, gender, and stage was comparable in both groups. Results: The overall survival rates at 7 years were not significantly different statistically between the two groups at 98.1% for the no-EBRT group and 90% for the EBRT group (p = 0.506). The locoregional control rates at 5 years were significantly different (EBRT 95.2% and no EBRT 67.5%; p = 0.0408). Analysis of the prognostic factors, age, gender, stage, and use of radioiodine ablative therapy, indicated these were not significant variables, except for EBRT. Conclusion: Adjuvant postoperative EBRT did not affect overall survival, but significantly improved locoregional control in patients with locally advanced papillary thyroid cancer (Stage pT4 or lymph node involvement).

KW - External beam radiotherapy

KW - Locoregional control

KW - Papillary thyroid carcinoma

UR - http://www.scopus.com/inward/record.url?scp=0037443528&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037443528&partnerID=8YFLogxK

U2 - 10.1016/S0360-3016(02)04203-7

DO - 10.1016/S0360-3016(02)04203-7

M3 - Article

C2 - 12605980

AN - SCOPUS:0037443528

VL - 55

SP - 1006

EP - 1012

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 4

ER -