Variation in Sleep Stability with Differences in Severity of Sleep-Disordered Breathing in Children

Min Young Seo, Mun Soo Han, Yong Jun Jeong, Min Kyu Lee, Seongbin Park, Sun Jin Hwang, Seung Hoon Lee

Research output: Contribution to journalArticle

Abstract

Objectives: The aim of this study was to analyze the association between obstructive sleep apnea (OSA) severity and various cardiopulmonary coupling (CPC) parameters in children with OSA. Study design: Retrospective cross-sectional study. Methods: A cross-sectional study was conducted among 117 children (aged 7.96 ± 3.54 years, 86 male) who underwent both full-night polysomnography (PSG) and CPC for suspicion of sleep-disordered breathing (SDB). We analyzed the association between various CPC and PSG findings. Results: The apnea-hypopnea index (AHI) was negatively correlated with high frequency coupling (HFC, r = −0.374, P <.001) and very low frequency coupling (VLFC, r = −0.192, P =.038) and positively correlated with low frequency coupling (LFC, r = 0.503, P <.001), elevated low frequency coupling (e-LFC, r = 0.475, P <.001), and narrow and broad band e-LFC (e-LFCNB and e-LFCBB; r = 0.221, P =.016 and r = 0.468, P <.001, respectively). The arousal index was negatively correlated with HFC (r = − 0.466, P <.001) and positively correlated with LFC, e-LFC, e-LFCNB, and e-LFCBB (r = 0.543, r = 0.460, r = 0.239, and r = 0.445, respectively; all P <.001). In addition, we also found a significant difference in various CPC values according to OSA severity. Conclusion: CPC parameters accurately reflect sleep fragmentation and OSA severity in children. Thus, we can verify objective sleep quality using CPC analysis, which is a simple method of analyzing sleep stability in children with SDB. Level of Evidence: 4 Laryngoscope, 2020.

Original languageEnglish
JournalLaryngoscope
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • Sleep-disordered breathing
  • cardiopulmonary coupling
  • child
  • polysomnography
  • sleep stability

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Seo, M. Y., Han, M. S., Jeong, Y. J., Lee, M. K., Park, S., Hwang, S. J., & Lee, S. H. (Accepted/In press). Variation in Sleep Stability with Differences in Severity of Sleep-Disordered Breathing in Children. Laryngoscope. https://doi.org/10.1002/lary.28769