Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via toll-like receptor 2

Jennifer P. Wang, Evelyn A. Kurt-Jones, Ok S. Shin, Michael D. Manchak, Myron J. Levin, Robert W. Finberg

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

The pattern recognition receptor Toll-like receptor 2 (TLR2) has been implicated in the response to several human viruses, including herpes simplex viruses (types 1 and 2) and cytomegalovirus. We demonstrated that varicella-zoster virus (VZV) activates inflammatory cytokine responses via TLR2. VZV specifically induced interleukin-6 (IL-6) in human monocytes via TLR2-dependent activation of NF-κB, and small interfering RNA designed to suppress TLR2 mRNA reduced the IL-6 response to VZV in human monocyte-derived macrophages. Unlike other herpesviruses, the cytokine response to VZV was species specific. VZV did not induce cytokines in murine embryonic fibroblasts or in a mouse cell line, although VZV did activate NF-κB in a human cell line expressing a murine TLR2 construct. Together, these results suggest that TLR2 may play a role in the inflammatory response to VZV infection.

Original languageEnglish
Pages (from-to)12658-12666
Number of pages9
JournalJournal of virology
Volume79
Issue number20
DOIs
Publication statusPublished - 2005 Oct 1

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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