Vascular characterization of clear cell sarcoma of the kidney in a child

a case report and review

Yoon-Jung Boo, Jason C. Fisher, Mary Jo Haley, Robert A. Cowles, Jessica J. Kandel, Darrell J. Yamashiro

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Clear cell sarcoma of the kidney (CCSK) is uncommon pediatric renal tumor and can present a significant therapeutic challenge in those patients whose tumors spread beyond the kidney. Thus, identifying potential novel targets for treatment may be clinically important. Clear cell sarcoma of the kidney is characterized by a unique vascular pattern, in which nests of tumor cells are separated by regularly-spaced, fine fibrovascular septa. This distinctive histopathology raises the possibility that understanding the factors which drive angiogenesis in CCSK tumors may suggest new therapeutic targets. Here, we describe a case of CCSK and present immunohistochemical studies of its vasculature.

Original languageEnglish
Pages (from-to)2031-2036
Number of pages6
JournalJournal of Pediatric Surgery
Volume44
Issue number10
DOIs
Publication statusPublished - 2009 Oct 1

Fingerprint

Clear Cell Sarcoma
Blood Vessels
Kidney
Neoplasms
Therapeutics
Pediatrics

Keywords

  • Angiopoietin
  • c-KIT
  • Clear cell sarcoma of the kidney
  • Notch
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Boo, Y-J., Fisher, J. C., Haley, M. J., Cowles, R. A., Kandel, J. J., & Yamashiro, D. J. (2009). Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review. Journal of Pediatric Surgery, 44(10), 2031-2036. https://doi.org/10.1016/j.jpedsurg.2009.06.023

Vascular characterization of clear cell sarcoma of the kidney in a child : a case report and review. / Boo, Yoon-Jung; Fisher, Jason C.; Haley, Mary Jo; Cowles, Robert A.; Kandel, Jessica J.; Yamashiro, Darrell J.

In: Journal of Pediatric Surgery, Vol. 44, No. 10, 01.10.2009, p. 2031-2036.

Research output: Contribution to journalArticle

Boo, Y-J, Fisher, JC, Haley, MJ, Cowles, RA, Kandel, JJ & Yamashiro, DJ 2009, 'Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review', Journal of Pediatric Surgery, vol. 44, no. 10, pp. 2031-2036. https://doi.org/10.1016/j.jpedsurg.2009.06.023
Boo, Yoon-Jung ; Fisher, Jason C. ; Haley, Mary Jo ; Cowles, Robert A. ; Kandel, Jessica J. ; Yamashiro, Darrell J. / Vascular characterization of clear cell sarcoma of the kidney in a child : a case report and review. In: Journal of Pediatric Surgery. 2009 ; Vol. 44, No. 10. pp. 2031-2036.
@article{ef61d39fec5f4bef8b35ca786b70c9ad,
title = "Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review",
abstract = "Clear cell sarcoma of the kidney (CCSK) is uncommon pediatric renal tumor and can present a significant therapeutic challenge in those patients whose tumors spread beyond the kidney. Thus, identifying potential novel targets for treatment may be clinically important. Clear cell sarcoma of the kidney is characterized by a unique vascular pattern, in which nests of tumor cells are separated by regularly-spaced, fine fibrovascular septa. This distinctive histopathology raises the possibility that understanding the factors which drive angiogenesis in CCSK tumors may suggest new therapeutic targets. Here, we describe a case of CCSK and present immunohistochemical studies of its vasculature.",
keywords = "Angiopoietin, c-KIT, Clear cell sarcoma of the kidney, Notch, Vascular endothelial growth factor",
author = "Yoon-Jung Boo and Fisher, {Jason C.} and Haley, {Mary Jo} and Cowles, {Robert A.} and Kandel, {Jessica J.} and Yamashiro, {Darrell J.}",
year = "2009",
month = "10",
day = "1",
doi = "10.1016/j.jpedsurg.2009.06.023",
language = "English",
volume = "44",
pages = "2031--2036",
journal = "Journal of Pediatric Surgery",
issn = "0022-3468",
publisher = "W.B. Saunders Ltd",
number = "10",

}

TY - JOUR

T1 - Vascular characterization of clear cell sarcoma of the kidney in a child

T2 - a case report and review

AU - Boo, Yoon-Jung

AU - Fisher, Jason C.

AU - Haley, Mary Jo

AU - Cowles, Robert A.

AU - Kandel, Jessica J.

AU - Yamashiro, Darrell J.

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Clear cell sarcoma of the kidney (CCSK) is uncommon pediatric renal tumor and can present a significant therapeutic challenge in those patients whose tumors spread beyond the kidney. Thus, identifying potential novel targets for treatment may be clinically important. Clear cell sarcoma of the kidney is characterized by a unique vascular pattern, in which nests of tumor cells are separated by regularly-spaced, fine fibrovascular septa. This distinctive histopathology raises the possibility that understanding the factors which drive angiogenesis in CCSK tumors may suggest new therapeutic targets. Here, we describe a case of CCSK and present immunohistochemical studies of its vasculature.

AB - Clear cell sarcoma of the kidney (CCSK) is uncommon pediatric renal tumor and can present a significant therapeutic challenge in those patients whose tumors spread beyond the kidney. Thus, identifying potential novel targets for treatment may be clinically important. Clear cell sarcoma of the kidney is characterized by a unique vascular pattern, in which nests of tumor cells are separated by regularly-spaced, fine fibrovascular septa. This distinctive histopathology raises the possibility that understanding the factors which drive angiogenesis in CCSK tumors may suggest new therapeutic targets. Here, we describe a case of CCSK and present immunohistochemical studies of its vasculature.

KW - Angiopoietin

KW - c-KIT

KW - Clear cell sarcoma of the kidney

KW - Notch

KW - Vascular endothelial growth factor

UR - http://www.scopus.com/inward/record.url?scp=70350061544&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350061544&partnerID=8YFLogxK

U2 - 10.1016/j.jpedsurg.2009.06.023

DO - 10.1016/j.jpedsurg.2009.06.023

M3 - Article

VL - 44

SP - 2031

EP - 2036

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

SN - 0022-3468

IS - 10

ER -