Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review

Yoon Jung Boo, Jason C. Fisher, Mary Jo Haley, Robert A. Cowles, Jessica J. Kandel, Darrell J. Yamashiro

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Clear cell sarcoma of the kidney (CCSK) is uncommon pediatric renal tumor and can present a significant therapeutic challenge in those patients whose tumors spread beyond the kidney. Thus, identifying potential novel targets for treatment may be clinically important. Clear cell sarcoma of the kidney is characterized by a unique vascular pattern, in which nests of tumor cells are separated by regularly-spaced, fine fibrovascular septa. This distinctive histopathology raises the possibility that understanding the factors which drive angiogenesis in CCSK tumors may suggest new therapeutic targets. Here, we describe a case of CCSK and present immunohistochemical studies of its vasculature.

Original languageEnglish
Pages (from-to)2031-2036
Number of pages6
JournalJournal of Pediatric Surgery
Volume44
Issue number10
DOIs
Publication statusPublished - 2009 Oct

Keywords

  • Angiopoietin
  • Clear cell sarcoma of the kidney
  • Notch
  • Vascular endothelial growth factor
  • c-KIT

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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    Boo, Y. J., Fisher, J. C., Haley, M. J., Cowles, R. A., Kandel, J. J., & Yamashiro, D. J. (2009). Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review. Journal of Pediatric Surgery, 44(10), 2031-2036. https://doi.org/10.1016/j.jpedsurg.2009.06.023