Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review

Yoon Jung Boo, Jason C. Fisher, Mary Jo Haley, Robert A. Cowles, Jessica J. Kandel, Darrell J. Yamashiro

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    Clear cell sarcoma of the kidney (CCSK) is uncommon pediatric renal tumor and can present a significant therapeutic challenge in those patients whose tumors spread beyond the kidney. Thus, identifying potential novel targets for treatment may be clinically important. Clear cell sarcoma of the kidney is characterized by a unique vascular pattern, in which nests of tumor cells are separated by regularly-spaced, fine fibrovascular septa. This distinctive histopathology raises the possibility that understanding the factors which drive angiogenesis in CCSK tumors may suggest new therapeutic targets. Here, we describe a case of CCSK and present immunohistochemical studies of its vasculature.

    Original languageEnglish
    Pages (from-to)2031-2036
    Number of pages6
    JournalJournal of Pediatric Surgery
    Volume44
    Issue number10
    DOIs
    Publication statusPublished - 2009 Oct

    Keywords

    • Angiopoietin
    • Clear cell sarcoma of the kidney
    • Notch
    • Vascular endothelial growth factor
    • c-KIT

    ASJC Scopus subject areas

    • Surgery
    • Pediatrics, Perinatology, and Child Health

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