Vasomotor symptoms and osteoporosis in Korean postmenopausal women

Research output: Contribution to journalArticle

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Abstract

Objectives This study examined the relationships between vasomotor symptoms (VMS), bone mineral density (BMD) and osteoporosis in postmenopausal women. Study design A cross-sectional study was conducted of 1390 postmenopausal Korean women aged 45-65 years who attended a routine health check-up at a single institution. Their results on the Menopause Rating Scale were used to assess VMS, and moderate, severe, and very severe VMS were combined into moderate-to-severe VMS. Main outcome measures The relationships of VMS with BMD and osteoporosis in the lumbar spine and femoral neck bone were analyzed by multivariate regression analyses. Results The mean age of all participants was 54.63 ± 4.78 years. Four hundred seventy-one (33.9%) women reported mild VMS and 344 (24.7%) reported moderate-to-severe VMS. Osteoporosis was newly diagnosed in 156 (11.2%) women. BMD levels were not significantly different among the no/mild/moderate-to-severe VMS groups, despite the significant differences in the prevalence of osteoporosis in the femoral neck bone. Women with mild VMS and those with moderate-to-severe VMS had a lower BMD than women without VMS after adjustment for age, years since menopause, years of reproductive age, BMI, insulin resistance, smoking, alcohol, steroids use, exercise, previous fracture and parental history of hip fracture. And moderate-to-severe VMS was significantly associated with the risk of osteoporosis in the femoral neck bone (OR = 2.97, 95% CI = 1.41-6.26) and in the lumbar spine (OR = 1.93, 95% CI = 1.09-3.40). Conclusions VMS are associated with decreased BMD, and moderate-to-severe VMS in particular are independently associated with the risk of osteoporosis in otherwise healthy postmenopausal Korean women.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalMaturitas
Volume87
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Osteoporosis
Bone
Bone Density
Minerals
Femur Neck
Menopause
Bone and Bones
Spine
Postmenopausal Osteoporosis
Hip Fractures
Insulin Resistance
Multivariate Analysis
Cross-Sectional Studies
Smoking
Steroids
Regression Analysis
Alcohols
Outcome Assessment (Health Care)
Exercise
Health

Keywords

  • Bone mineral density
  • Osteoporosis
  • Post-menopause
  • Vasomotor symptoms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Obstetrics and Gynaecology

Cite this

Vasomotor symptoms and osteoporosis in Korean postmenopausal women. / Ryu, Ki Jin; Park, Hyun-Tae; Kim, Yong Jin; Yi, Kyong Wook; Shin, Jung-Ho; Hur, Jun Young; Kim, Tak.

In: Maturitas, Vol. 87, 01.01.2016, p. 27-32.

Research output: Contribution to journalArticle

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title = "Vasomotor symptoms and osteoporosis in Korean postmenopausal women",
abstract = "Objectives This study examined the relationships between vasomotor symptoms (VMS), bone mineral density (BMD) and osteoporosis in postmenopausal women. Study design A cross-sectional study was conducted of 1390 postmenopausal Korean women aged 45-65 years who attended a routine health check-up at a single institution. Their results on the Menopause Rating Scale were used to assess VMS, and moderate, severe, and very severe VMS were combined into moderate-to-severe VMS. Main outcome measures The relationships of VMS with BMD and osteoporosis in the lumbar spine and femoral neck bone were analyzed by multivariate regression analyses. Results The mean age of all participants was 54.63 ± 4.78 years. Four hundred seventy-one (33.9{\%}) women reported mild VMS and 344 (24.7{\%}) reported moderate-to-severe VMS. Osteoporosis was newly diagnosed in 156 (11.2{\%}) women. BMD levels were not significantly different among the no/mild/moderate-to-severe VMS groups, despite the significant differences in the prevalence of osteoporosis in the femoral neck bone. Women with mild VMS and those with moderate-to-severe VMS had a lower BMD than women without VMS after adjustment for age, years since menopause, years of reproductive age, BMI, insulin resistance, smoking, alcohol, steroids use, exercise, previous fracture and parental history of hip fracture. And moderate-to-severe VMS was significantly associated with the risk of osteoporosis in the femoral neck bone (OR = 2.97, 95{\%} CI = 1.41-6.26) and in the lumbar spine (OR = 1.93, 95{\%} CI = 1.09-3.40). Conclusions VMS are associated with decreased BMD, and moderate-to-severe VMS in particular are independently associated with the risk of osteoporosis in otherwise healthy postmenopausal Korean women.",
keywords = "Bone mineral density, Osteoporosis, Post-menopause, Vasomotor symptoms",
author = "Ryu, {Ki Jin} and Hyun-Tae Park and Kim, {Yong Jin} and Yi, {Kyong Wook} and Jung-Ho Shin and Hur, {Jun Young} and Tak Kim",
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AU - Ryu, Ki Jin

AU - Park, Hyun-Tae

AU - Kim, Yong Jin

AU - Yi, Kyong Wook

AU - Shin, Jung-Ho

AU - Hur, Jun Young

AU - Kim, Tak

PY - 2016/1/1

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N2 - Objectives This study examined the relationships between vasomotor symptoms (VMS), bone mineral density (BMD) and osteoporosis in postmenopausal women. Study design A cross-sectional study was conducted of 1390 postmenopausal Korean women aged 45-65 years who attended a routine health check-up at a single institution. Their results on the Menopause Rating Scale were used to assess VMS, and moderate, severe, and very severe VMS were combined into moderate-to-severe VMS. Main outcome measures The relationships of VMS with BMD and osteoporosis in the lumbar spine and femoral neck bone were analyzed by multivariate regression analyses. Results The mean age of all participants was 54.63 ± 4.78 years. Four hundred seventy-one (33.9%) women reported mild VMS and 344 (24.7%) reported moderate-to-severe VMS. Osteoporosis was newly diagnosed in 156 (11.2%) women. BMD levels were not significantly different among the no/mild/moderate-to-severe VMS groups, despite the significant differences in the prevalence of osteoporosis in the femoral neck bone. Women with mild VMS and those with moderate-to-severe VMS had a lower BMD than women without VMS after adjustment for age, years since menopause, years of reproductive age, BMI, insulin resistance, smoking, alcohol, steroids use, exercise, previous fracture and parental history of hip fracture. And moderate-to-severe VMS was significantly associated with the risk of osteoporosis in the femoral neck bone (OR = 2.97, 95% CI = 1.41-6.26) and in the lumbar spine (OR = 1.93, 95% CI = 1.09-3.40). Conclusions VMS are associated with decreased BMD, and moderate-to-severe VMS in particular are independently associated with the risk of osteoporosis in otherwise healthy postmenopausal Korean women.

AB - Objectives This study examined the relationships between vasomotor symptoms (VMS), bone mineral density (BMD) and osteoporosis in postmenopausal women. Study design A cross-sectional study was conducted of 1390 postmenopausal Korean women aged 45-65 years who attended a routine health check-up at a single institution. Their results on the Menopause Rating Scale were used to assess VMS, and moderate, severe, and very severe VMS were combined into moderate-to-severe VMS. Main outcome measures The relationships of VMS with BMD and osteoporosis in the lumbar spine and femoral neck bone were analyzed by multivariate regression analyses. Results The mean age of all participants was 54.63 ± 4.78 years. Four hundred seventy-one (33.9%) women reported mild VMS and 344 (24.7%) reported moderate-to-severe VMS. Osteoporosis was newly diagnosed in 156 (11.2%) women. BMD levels were not significantly different among the no/mild/moderate-to-severe VMS groups, despite the significant differences in the prevalence of osteoporosis in the femoral neck bone. Women with mild VMS and those with moderate-to-severe VMS had a lower BMD than women without VMS after adjustment for age, years since menopause, years of reproductive age, BMI, insulin resistance, smoking, alcohol, steroids use, exercise, previous fracture and parental history of hip fracture. And moderate-to-severe VMS was significantly associated with the risk of osteoporosis in the femoral neck bone (OR = 2.97, 95% CI = 1.41-6.26) and in the lumbar spine (OR = 1.93, 95% CI = 1.09-3.40). Conclusions VMS are associated with decreased BMD, and moderate-to-severe VMS in particular are independently associated with the risk of osteoporosis in otherwise healthy postmenopausal Korean women.

KW - Bone mineral density

KW - Osteoporosis

KW - Post-menopause

KW - Vasomotor symptoms

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