VEGF overexpression predicts poor survival in hepatocellular carcinoma

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The aim of this study was to investigate the clinicopathological and immunohistochemical (including VEGF, Akt, HSP70, and HSP20 expression) factors that affect the overall and disease-free survival of HCC patients following surgical resection. 234 patients with HCC following surgical resection were enrolled. Clinicopathological and survival data were analyzed, and immunohistochemical staining was performed on tissue microarray sections using the anti-VEGF, anti-Akt, anti-HSP70, and anti-HSP27 antibodies. The 3-A nd 5-year overall survival rates were 86.5 and 81.54%, respectively. Multivariate analysis revealed that VEGF expression (P = 0.017, HR = 2.573) and T stage (P < 0.001, HR = 4.953) were independent prognostic factors for overall survival. Immunohistochemical staining showed that the expression of Akt, HSP70, and HSP27 did not affect the overall survival rate. The 3-A nd 5-year disease-free survival rates were 58.2 and 49.4%, respectively. Compared to the VEGF(-)/(+) group, the VEGF(++)/(+++) group demonstrated significantly higher proportion of patients with AFP levels > 400 ng/mL, capsule invasion, and microvascular invasion. VEGF overexpression was associated with capsule invasion, microvascular invasion, and a poor overall survival rate.

Original languageEnglish
Pages (from-to)430-439
Number of pages10
JournalOpen Medicine (Poland)
Volume12
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

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Vascular Endothelial Growth Factor A
Hepatocellular Carcinoma
Survival
Capsules
Survival Rate
Disease-Free Survival
Anti-Idiotypic Antibodies
Multivariate Analysis
Staining and Labeling

Keywords

  • hepatic resection
  • Hepatocellular carcinoma
  • prognostic marker
  • VEGF

ASJC Scopus subject areas

  • Medicine(all)

Cite this

VEGF overexpression predicts poor survival in hepatocellular carcinoma. / Choi, Sae-Byeol; Han, Hyung Joon; Kim, Wan-Bae; Song, Taejin; Choi, Sang Yong.

In: Open Medicine (Poland), Vol. 12, No. 1, 01.01.2017, p. 430-439.

Research output: Contribution to journalArticle

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AU - Choi, Sang Yong

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