TY - JOUR
T1 - Ventricular premature beat-driven intermittent restoration of coronary blood flow reduces the incidence of reperfusion-induced ventricular fibrillation in a cat model of regional ischemia
AU - Heung Sik Na, Sik Na
AU - Yang In Kim, In Kim
AU - Young Wook Yoon, Wook Yoon
AU - Hee Chul Han, Chul Han
AU - Sook Hyun Nahm, Hyun Nahm
AU - Seung Kil Hong, Kil Hong
N1 - Funding Information:
From the Department of Physiology, Korea University College of Medicine. Supported in part by nondirected research fund from the Korea University College of Medicine. Received for publication July 27, 1995; accepted Nov. 27, 1995. Reprint requests: Heuug Sik Na, MD, Department of Physiology, College of Medicine, Korea University, 126-1 Anam-dong 5 ga, Sungbuk-gu, Seoul, Korea 136-705. Copyright © 1996 by Mosby-Year Book, Inc. 0002-8703/96/$5.00 + 0 4/1/72016
PY - 1996
Y1 - 1996
N2 - With a cat model of regional cardiac ischemia, we examined whether the incidence of reperfusion-induced ventricular fibrillation (VF) could be reduced by ventricular premature beat (VPB)-driven intermittent reperfusion. In addition, we assessed whether the effect of the intermittent reperfusion was comparable with that of ischemic preconditioning in suppressing the VF. Of 15 cats subjected to uninterrupted reperfusion after 20-minute occlusion of the left anterior descending coronary artery, 13 (86.7%) had VF, whereas only 1 (7.1%) of 14 cats subjected to the VPB-driven intermittent reperfusion had VF. This incidence of VF was significantly lower than that of the animal group subjected to uninterrupted reperfusion. However, it was not statistically different from that (3 of 15) of the group subjected to a 10- minute episode of the coronary artery occlusion before the 20-minute occlusion (i.e., 'ischemic preconditioning'). Our results suggest that the VPB-driven intermittent reperfusion (i.e., 'postconditioning') is very effective in preventing reperfusion-induced VF and as good as, if not better than, ischemic preconditioning.
AB - With a cat model of regional cardiac ischemia, we examined whether the incidence of reperfusion-induced ventricular fibrillation (VF) could be reduced by ventricular premature beat (VPB)-driven intermittent reperfusion. In addition, we assessed whether the effect of the intermittent reperfusion was comparable with that of ischemic preconditioning in suppressing the VF. Of 15 cats subjected to uninterrupted reperfusion after 20-minute occlusion of the left anterior descending coronary artery, 13 (86.7%) had VF, whereas only 1 (7.1%) of 14 cats subjected to the VPB-driven intermittent reperfusion had VF. This incidence of VF was significantly lower than that of the animal group subjected to uninterrupted reperfusion. However, it was not statistically different from that (3 of 15) of the group subjected to a 10- minute episode of the coronary artery occlusion before the 20-minute occlusion (i.e., 'ischemic preconditioning'). Our results suggest that the VPB-driven intermittent reperfusion (i.e., 'postconditioning') is very effective in preventing reperfusion-induced VF and as good as, if not better than, ischemic preconditioning.
UR - http://www.scopus.com/inward/record.url?scp=0030013497&partnerID=8YFLogxK
U2 - 10.1016/S0002-8703(96)90393-2
DO - 10.1016/S0002-8703(96)90393-2
M3 - Article
C2 - 8701879
AN - SCOPUS:0030013497
SN - 0002-8703
VL - 132
SP - 78
EP - 83
JO - American Heart Journal
JF - American Heart Journal
IS - 1 I
ER -