Ventricular premature beat-driven intermittent restoration of coronary blood flow reduces the incidence of reperfusion-induced ventricular fibrillation in a cat model of regional ischemia

Sik Na Heung Sik Na, Yang In Kim, Young Wook Yoon, Hee Chul Han, Hyun Nahm Sook Hyun Nahm, Kil Hong Seung Kil Hong

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With a cat model of regional cardiac ischemia, we examined whether the incidence of reperfusion-induced ventricular fibrillation (VF) could be reduced by ventricular premature beat (VPB)-driven intermittent reperfusion. In addition, we assessed whether the effect of the intermittent reperfusion was comparable with that of ischemic preconditioning in suppressing the VF. Of 15 cats subjected to uninterrupted reperfusion after 20-minute occlusion of the left anterior descending coronary artery, 13 (86.7%) had VF, whereas only 1 (7.1%) of 14 cats subjected to the VPB-driven intermittent reperfusion had VF. This incidence of VF was significantly lower than that of the animal group subjected to uninterrupted reperfusion. However, it was not statistically different from that (3 of 15) of the group subjected to a 10- minute episode of the coronary artery occlusion before the 20-minute occlusion (i.e., 'ischemic preconditioning'). Our results suggest that the VPB-driven intermittent reperfusion (i.e., 'postconditioning') is very effective in preventing reperfusion-induced VF and as good as, if not better than, ischemic preconditioning.

Original languageEnglish
Pages (from-to)78-83
Number of pages6
JournalAmerican Heart Journal
Issue number1 I
Publication statusPublished - 1996 Aug 2


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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