Abstract
With a cat model of regional cardiac ischemia, we examined whether the incidence of reperfusion-induced ventricular fibrillation (VF) could be reduced by ventricular premature beat (VPB)-driven intermittent reperfusion. In addition, we assessed whether the effect of the intermittent reperfusion was comparable with that of ischemic preconditioning in suppressing the VF. Of 15 cats subjected to uninterrupted reperfusion after 20-minute occlusion of the left anterior descending coronary artery, 13 (86.7%) had VF, whereas only 1 (7.1%) of 14 cats subjected to the VPB-driven intermittent reperfusion had VF. This incidence of VF was significantly lower than that of the animal group subjected to uninterrupted reperfusion. However, it was not statistically different from that (3 of 15) of the group subjected to a 10- minute episode of the coronary artery occlusion before the 20-minute occlusion (i.e., 'ischemic preconditioning'). Our results suggest that the VPB-driven intermittent reperfusion (i.e., 'postconditioning') is very effective in preventing reperfusion-induced VF and as good as, if not better than, ischemic preconditioning.
| Original language | English |
|---|---|
| Pages (from-to) | 78-83 |
| Number of pages | 6 |
| Journal | American Heart Journal |
| Volume | 132 |
| Issue number | 1 I |
| DOIs | |
| Publication status | Published - 1996 Aug 2 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Ventricular premature beat-driven intermittent restoration of coronary blood flow reduces the incidence of reperfusion-induced ventricular fibrillation in a cat model of regional ischemia. / Heung Sik Na, Sik Na; Kim, Yang In; Yoon, Young Wook; Han, Hee Chul; Sook Hyun Nahm, Hyun Nahm; Seung Kil Hong, Kil Hong.
In: American Heart Journal, Vol. 132, No. 1 I, 02.08.1996, p. 78-83.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ventricular premature beat-driven intermittent restoration of coronary blood flow reduces the incidence of reperfusion-induced ventricular fibrillation in a cat model of regional ischemia
AU - Heung Sik Na, Sik Na
AU - Kim, Yang In
AU - Yoon, Young Wook
AU - Han, Hee Chul
AU - Sook Hyun Nahm, Hyun Nahm
AU - Seung Kil Hong, Kil Hong
PY - 1996/8/2
Y1 - 1996/8/2
N2 - With a cat model of regional cardiac ischemia, we examined whether the incidence of reperfusion-induced ventricular fibrillation (VF) could be reduced by ventricular premature beat (VPB)-driven intermittent reperfusion. In addition, we assessed whether the effect of the intermittent reperfusion was comparable with that of ischemic preconditioning in suppressing the VF. Of 15 cats subjected to uninterrupted reperfusion after 20-minute occlusion of the left anterior descending coronary artery, 13 (86.7%) had VF, whereas only 1 (7.1%) of 14 cats subjected to the VPB-driven intermittent reperfusion had VF. This incidence of VF was significantly lower than that of the animal group subjected to uninterrupted reperfusion. However, it was not statistically different from that (3 of 15) of the group subjected to a 10- minute episode of the coronary artery occlusion before the 20-minute occlusion (i.e., 'ischemic preconditioning'). Our results suggest that the VPB-driven intermittent reperfusion (i.e., 'postconditioning') is very effective in preventing reperfusion-induced VF and as good as, if not better than, ischemic preconditioning.
AB - With a cat model of regional cardiac ischemia, we examined whether the incidence of reperfusion-induced ventricular fibrillation (VF) could be reduced by ventricular premature beat (VPB)-driven intermittent reperfusion. In addition, we assessed whether the effect of the intermittent reperfusion was comparable with that of ischemic preconditioning in suppressing the VF. Of 15 cats subjected to uninterrupted reperfusion after 20-minute occlusion of the left anterior descending coronary artery, 13 (86.7%) had VF, whereas only 1 (7.1%) of 14 cats subjected to the VPB-driven intermittent reperfusion had VF. This incidence of VF was significantly lower than that of the animal group subjected to uninterrupted reperfusion. However, it was not statistically different from that (3 of 15) of the group subjected to a 10- minute episode of the coronary artery occlusion before the 20-minute occlusion (i.e., 'ischemic preconditioning'). Our results suggest that the VPB-driven intermittent reperfusion (i.e., 'postconditioning') is very effective in preventing reperfusion-induced VF and as good as, if not better than, ischemic preconditioning.
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U2 - 10.1016/S0002-8703(96)90393-2
DO - 10.1016/S0002-8703(96)90393-2
M3 - Article
VL - 132
SP - 78
EP - 83
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 1 I
ER -