Versatile chemical derivatizations to design glycol chitosan-based drug carriers

Sung Eun Kim, Hak Jun Kim, Jin Kyu Rhee, Kyeongsoon Park

    Research output: Contribution to journalReview articlepeer-review

    6 Citations (Scopus)

    Abstract

    Glycol chitosan (GC) and its derivatives have been extensively investigated as safe and effective drug delivery carriers because of their unique physiochemical and biological properties. The reactive functional groups such as the amine and hydroxyl groups on the GC backbone allow for easy chemical modification with various chemical compounds (e.g., hydrophobic molecules, crosslinkers, and acid-sensitive and labile molecules), and the versatility in chemical modifications enables production of a wide range of GC-based drug carriers. This review summarizes the versatile chemical modification methods that can be used to design GC-based drug carriers and describes their recent applications in disease therapy.

    Original languageEnglish
    Article number1662
    JournalMolecules
    Volume22
    Issue number10
    DOIs
    Publication statusPublished - 2017 Oct

    Keywords

    • Chemical derivatizations
    • Disease therapy
    • Drug carriers
    • Glycol chitosan
    • Nanoparticles

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Chemistry (miscellaneous)
    • Molecular Medicine
    • Pharmaceutical Science
    • Drug Discovery
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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