Vertebrobasilar dolichoectasia as a risk factor for cerebral microbleeds

J. M. Park, J. S. Koo, B. K. Kim, O. Kwon, J. J. Lee, K. Kang, J. S. Lee, Juneyoung Lee, H. J. Bae

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Both vertebrobasilar dolichoectasia (VBD) and cerebral microbleeds (CMBs) are related with the risk of intracerebral hemorrhage. We aimed to examine the relationship between the VBD and CMB in ischaemic stroke patients. Methods: A consecutive series of 182 patients hospitalized because of ischaemic stroke or transient ischaemic attack (TIA), and who underwent gradient echo brain magnetic resonance imaging were retrospectively recruited from a prospective stroke registry. CMB locations were categorized into anterior and posterior circulation. Ectasia was defined as basilar artery (BA) diameter >4.5mm, and dolichosis, as either BA bifurcation above the suprasellar cistern or lateral to the margin of the clivus or dorsum sellae. Whether VBD is associated with CMB anywhere in the brain or in anterior or posterior circulation territories was analysed using binary and multinomial logistic regression models. Results: Twenty-four subjects (13.2%) had VBD and 48 (26.4%) had CMBs. CMBs were more frequently observed in patients with VBD than without (66.7% vs. 20.3%, P<0.001). VBD was significantly associated with CMBs in any location (crude odds ratio, 7.88; 95% confidence interval, 3.10-20.02), in the posterior circulation territory only (9.63; 2.60-34.94), and in both territories (9.25; 3.40-26.29), but not in the anterior circulation only (1.14; 0.009-11.20). These associations remained unchanged after adjusting for age, gender, hypertension, leukoaraiosis and stroke subtype. Conclusions: VBD in patients with ischaemic stroke or TIA is independently associated with CMBs, especially in the posterior circulation territory.

Original languageEnglish
Pages (from-to)824-830
Number of pages7
JournalEuropean Journal of Neurology
Volume20
Issue number5
DOIs
Publication statusPublished - 2013 May 1

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Vertebrobasilar Insufficiency
Stroke
Basilar Artery
Transient Ischemic Attack
Logistic Models
Leukoaraiosis
Posterior Cranial Fossa
Pathologic Dilatations
Cerebral Hemorrhage
Brain
Registries
Odds Ratio
Magnetic Resonance Imaging
Confidence Intervals
Hypertension

Keywords

  • Cerebral hemorrhage
  • Cerebral microbleeds
  • Dolichoectasia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Park, J. M., Koo, J. S., Kim, B. K., Kwon, O., Lee, J. J., Kang, K., ... Bae, H. J. (2013). Vertebrobasilar dolichoectasia as a risk factor for cerebral microbleeds. European Journal of Neurology, 20(5), 824-830. https://doi.org/10.1111/ene.12075

Vertebrobasilar dolichoectasia as a risk factor for cerebral microbleeds. / Park, J. M.; Koo, J. S.; Kim, B. K.; Kwon, O.; Lee, J. J.; Kang, K.; Lee, J. S.; Lee, Juneyoung; Bae, H. J.

In: European Journal of Neurology, Vol. 20, No. 5, 01.05.2013, p. 824-830.

Research output: Contribution to journalArticle

Park, JM, Koo, JS, Kim, BK, Kwon, O, Lee, JJ, Kang, K, Lee, JS, Lee, J & Bae, HJ 2013, 'Vertebrobasilar dolichoectasia as a risk factor for cerebral microbleeds', European Journal of Neurology, vol. 20, no. 5, pp. 824-830. https://doi.org/10.1111/ene.12075
Park, J. M. ; Koo, J. S. ; Kim, B. K. ; Kwon, O. ; Lee, J. J. ; Kang, K. ; Lee, J. S. ; Lee, Juneyoung ; Bae, H. J. / Vertebrobasilar dolichoectasia as a risk factor for cerebral microbleeds. In: European Journal of Neurology. 2013 ; Vol. 20, No. 5. pp. 824-830.
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abstract = "Background: Both vertebrobasilar dolichoectasia (VBD) and cerebral microbleeds (CMBs) are related with the risk of intracerebral hemorrhage. We aimed to examine the relationship between the VBD and CMB in ischaemic stroke patients. Methods: A consecutive series of 182 patients hospitalized because of ischaemic stroke or transient ischaemic attack (TIA), and who underwent gradient echo brain magnetic resonance imaging were retrospectively recruited from a prospective stroke registry. CMB locations were categorized into anterior and posterior circulation. Ectasia was defined as basilar artery (BA) diameter >4.5mm, and dolichosis, as either BA bifurcation above the suprasellar cistern or lateral to the margin of the clivus or dorsum sellae. Whether VBD is associated with CMB anywhere in the brain or in anterior or posterior circulation territories was analysed using binary and multinomial logistic regression models. Results: Twenty-four subjects (13.2{\%}) had VBD and 48 (26.4{\%}) had CMBs. CMBs were more frequently observed in patients with VBD than without (66.7{\%} vs. 20.3{\%}, P<0.001). VBD was significantly associated with CMBs in any location (crude odds ratio, 7.88; 95{\%} confidence interval, 3.10-20.02), in the posterior circulation territory only (9.63; 2.60-34.94), and in both territories (9.25; 3.40-26.29), but not in the anterior circulation only (1.14; 0.009-11.20). These associations remained unchanged after adjusting for age, gender, hypertension, leukoaraiosis and stroke subtype. Conclusions: VBD in patients with ischaemic stroke or TIA is independently associated with CMBs, especially in the posterior circulation territory.",
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AU - Koo, J. S.

AU - Kim, B. K.

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AU - Lee, J. J.

AU - Kang, K.

AU - Lee, J. S.

AU - Lee, Juneyoung

AU - Bae, H. J.

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N2 - Background: Both vertebrobasilar dolichoectasia (VBD) and cerebral microbleeds (CMBs) are related with the risk of intracerebral hemorrhage. We aimed to examine the relationship between the VBD and CMB in ischaemic stroke patients. Methods: A consecutive series of 182 patients hospitalized because of ischaemic stroke or transient ischaemic attack (TIA), and who underwent gradient echo brain magnetic resonance imaging were retrospectively recruited from a prospective stroke registry. CMB locations were categorized into anterior and posterior circulation. Ectasia was defined as basilar artery (BA) diameter >4.5mm, and dolichosis, as either BA bifurcation above the suprasellar cistern or lateral to the margin of the clivus or dorsum sellae. Whether VBD is associated with CMB anywhere in the brain or in anterior or posterior circulation territories was analysed using binary and multinomial logistic regression models. Results: Twenty-four subjects (13.2%) had VBD and 48 (26.4%) had CMBs. CMBs were more frequently observed in patients with VBD than without (66.7% vs. 20.3%, P<0.001). VBD was significantly associated with CMBs in any location (crude odds ratio, 7.88; 95% confidence interval, 3.10-20.02), in the posterior circulation territory only (9.63; 2.60-34.94), and in both territories (9.25; 3.40-26.29), but not in the anterior circulation only (1.14; 0.009-11.20). These associations remained unchanged after adjusting for age, gender, hypertension, leukoaraiosis and stroke subtype. Conclusions: VBD in patients with ischaemic stroke or TIA is independently associated with CMBs, especially in the posterior circulation territory.

AB - Background: Both vertebrobasilar dolichoectasia (VBD) and cerebral microbleeds (CMBs) are related with the risk of intracerebral hemorrhage. We aimed to examine the relationship between the VBD and CMB in ischaemic stroke patients. Methods: A consecutive series of 182 patients hospitalized because of ischaemic stroke or transient ischaemic attack (TIA), and who underwent gradient echo brain magnetic resonance imaging were retrospectively recruited from a prospective stroke registry. CMB locations were categorized into anterior and posterior circulation. Ectasia was defined as basilar artery (BA) diameter >4.5mm, and dolichosis, as either BA bifurcation above the suprasellar cistern or lateral to the margin of the clivus or dorsum sellae. Whether VBD is associated with CMB anywhere in the brain or in anterior or posterior circulation territories was analysed using binary and multinomial logistic regression models. Results: Twenty-four subjects (13.2%) had VBD and 48 (26.4%) had CMBs. CMBs were more frequently observed in patients with VBD than without (66.7% vs. 20.3%, P<0.001). VBD was significantly associated with CMBs in any location (crude odds ratio, 7.88; 95% confidence interval, 3.10-20.02), in the posterior circulation territory only (9.63; 2.60-34.94), and in both territories (9.25; 3.40-26.29), but not in the anterior circulation only (1.14; 0.009-11.20). These associations remained unchanged after adjusting for age, gender, hypertension, leukoaraiosis and stroke subtype. Conclusions: VBD in patients with ischaemic stroke or TIA is independently associated with CMBs, especially in the posterior circulation territory.

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