Vertically encoded tetragonal hydrogel microparticles for multiplexed biomolecule detection

Yoon Ho Roh, Sang Yun Yeom, Jungkyu Choi, Il Joo Cho, Nakwon Choi, Ki Wan Bong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Encoded hydrogel particles have drawn many attentions in diagnostics as the particles can be used for high-performance multiplexed assays. Here, we present encoded tetragonal hydrogel microparticles that are comprised of vertically distinct code and probe regions, and incorporated with quantum dots (QDs) in the code regions. By virtue of the particle geometry, particles can be synthesized at a high production rate in vertically stacked micro-flows using hydrodynamic focusing lithography. The particle coding capacity can be largely expanded by changing wavelengths of QDs and the number of code layers. We also demonstrate the multiplexed capability of the particles in a DNA assay.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1407-1409
Number of pages3
ISBN (Electronic)9780979806483
Publication statusPublished - 2015
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: 2015 Oct 252015 Oct 29

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period15/10/2515/10/29

Keywords

  • Hydrodynamic focusing lithography (HFL)
  • Multiplexed assay
  • Quantum dots (QDs)

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Roh, Y. H., Yeom, S. Y., Choi, J., Cho, I. J., Choi, N., & Bong, K. W. (2015). Vertically encoded tetragonal hydrogel microparticles for multiplexed biomolecule detection. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1407-1409). Chemical and Biological Microsystems Society.