Abstract
Olfactory dysfunction could happen following various insults such as ischemic-hypoxic state. Neurons of the main olfactory bulb (MOB) are resistant to ischemic damage. In the present study, we investigated the ischemia-related changes of neurons and glial cells in the glomerular layer (GL) of the gerbil MOB after transient ischemia. The number of NeuN-immunoreactive neurons became to decrease from 10 days after ischemic insult. Fifteen days after ischemic insult, astrocytes and microglia were increased in number. By 60 days after ischemia, NeuN-immunoreactive neurons were significantly decreased by 42% per glomerulus. At this time period, astrocytes and microglia were pronouncedly increased. This result indicates that neuronal loss must be much delayed in the GL following transient ischemia.
| Original language | English |
|---|---|
| Pages (from-to) | 272-276 |
| Number of pages | 5 |
| Journal | Neuroscience Letters |
| Volume | 366 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2004 Aug 19 |
| Externally published | Yes |
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Keywords
- Gerbil
- Gliosis
- Glomerular layer
- Main olfactory bulb
- NeuN
- Transient forebrain ischemia
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Very delayed neuronal loss occurs in the glomerular layer of the main olfactory bulb following transient ischemia in gerbils. / Hwang, In Koo; Lee, Jae Chul; Cho, Jun Hwi; Yoo, Ki Yeon; Kim, Duk Soo; Nam, Young Sam; Kim, Won-Ki; Lee, In S.; Kang, Tae Cheon; Won, Moo H.
In: Neuroscience Letters, Vol. 366, No. 3, 19.08.2004, p. 272-276.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Very delayed neuronal loss occurs in the glomerular layer of the main olfactory bulb following transient ischemia in gerbils
AU - Hwang, In Koo
AU - Lee, Jae Chul
AU - Cho, Jun Hwi
AU - Yoo, Ki Yeon
AU - Kim, Duk Soo
AU - Nam, Young Sam
AU - Kim, Won-Ki
AU - Lee, In S.
AU - Kang, Tae Cheon
AU - Won, Moo H.
PY - 2004/8/19
Y1 - 2004/8/19
N2 - Olfactory dysfunction could happen following various insults such as ischemic-hypoxic state. Neurons of the main olfactory bulb (MOB) are resistant to ischemic damage. In the present study, we investigated the ischemia-related changes of neurons and glial cells in the glomerular layer (GL) of the gerbil MOB after transient ischemia. The number of NeuN-immunoreactive neurons became to decrease from 10 days after ischemic insult. Fifteen days after ischemic insult, astrocytes and microglia were increased in number. By 60 days after ischemia, NeuN-immunoreactive neurons were significantly decreased by 42% per glomerulus. At this time period, astrocytes and microglia were pronouncedly increased. This result indicates that neuronal loss must be much delayed in the GL following transient ischemia.
AB - Olfactory dysfunction could happen following various insults such as ischemic-hypoxic state. Neurons of the main olfactory bulb (MOB) are resistant to ischemic damage. In the present study, we investigated the ischemia-related changes of neurons and glial cells in the glomerular layer (GL) of the gerbil MOB after transient ischemia. The number of NeuN-immunoreactive neurons became to decrease from 10 days after ischemic insult. Fifteen days after ischemic insult, astrocytes and microglia were increased in number. By 60 days after ischemia, NeuN-immunoreactive neurons were significantly decreased by 42% per glomerulus. At this time period, astrocytes and microglia were pronouncedly increased. This result indicates that neuronal loss must be much delayed in the GL following transient ischemia.
KW - Gerbil
KW - Gliosis
KW - Glomerular layer
KW - Main olfactory bulb
KW - NeuN
KW - Transient forebrain ischemia
UR - http://www.scopus.com/inward/record.url?scp=3543094570&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3543094570&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2004.05.071
DO - 10.1016/j.neulet.2004.05.071
M3 - Article
VL - 366
SP - 272
EP - 276
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -