Very delayed neuronal loss occurs in the glomerular layer of the main olfactory bulb following transient ischemia in gerbils

In Koo Hwang, Jae Chul Lee, Jun Hwi Cho, Ki Yeon Yoo, Duk Soo Kim, Young Sam Nam, Won-Ki Kim, In S. Lee, Tae Cheon Kang, Moo H. Won

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Olfactory dysfunction could happen following various insults such as ischemic-hypoxic state. Neurons of the main olfactory bulb (MOB) are resistant to ischemic damage. In the present study, we investigated the ischemia-related changes of neurons and glial cells in the glomerular layer (GL) of the gerbil MOB after transient ischemia. The number of NeuN-immunoreactive neurons became to decrease from 10 days after ischemic insult. Fifteen days after ischemic insult, astrocytes and microglia were increased in number. By 60 days after ischemia, NeuN-immunoreactive neurons were significantly decreased by 42% per glomerulus. At this time period, astrocytes and microglia were pronouncedly increased. This result indicates that neuronal loss must be much delayed in the GL following transient ischemia.

Original languageEnglish
Pages (from-to)272-276
Number of pages5
JournalNeuroscience Letters
Volume366
Issue number3
DOIs
Publication statusPublished - 2004 Aug 19
Externally publishedYes

Keywords

  • Gerbil
  • Gliosis
  • Glomerular layer
  • Main olfactory bulb
  • NeuN
  • Transient forebrain ischemia

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Hwang, I. K., Lee, J. C., Cho, J. H., Yoo, K. Y., Kim, D. S., Nam, Y. S., Kim, W-K., Lee, I. S., Kang, T. C., & Won, M. H. (2004). Very delayed neuronal loss occurs in the glomerular layer of the main olfactory bulb following transient ischemia in gerbils. Neuroscience Letters, 366(3), 272-276. https://doi.org/10.1016/j.neulet.2004.05.071