Abstract
Olfactory dysfunction could happen following various insults such as ischemic-hypoxic state. Neurons of the main olfactory bulb (MOB) are resistant to ischemic damage. In the present study, we investigated the ischemia-related changes of neurons and glial cells in the glomerular layer (GL) of the gerbil MOB after transient ischemia. The number of NeuN-immunoreactive neurons became to decrease from 10 days after ischemic insult. Fifteen days after ischemic insult, astrocytes and microglia were increased in number. By 60 days after ischemia, NeuN-immunoreactive neurons were significantly decreased by 42% per glomerulus. At this time period, astrocytes and microglia were pronouncedly increased. This result indicates that neuronal loss must be much delayed in the GL following transient ischemia.
Original language | English |
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Pages (from-to) | 272-276 |
Number of pages | 5 |
Journal | Neuroscience Letters |
Volume | 366 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2004 Aug 19 |
Externally published | Yes |
Keywords
- Gerbil
- Gliosis
- Glomerular layer
- Main olfactory bulb
- NeuN
- Transient forebrain ischemia
ASJC Scopus subject areas
- Neuroscience(all)