Vibrational solvatochromism of nitrile infrared probes: Beyond the vibrational Stark dipole approach

Bartosz Błasiak, Andrew W. Ritchie, Lauren J. Webb, Minhaeng Cho

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Systematic probing of local environments around biopolymers is important for understanding their functions. Therefore, there has been growing interest in in situ measurements of molecular granularity and heterogeneity through the systematic analysis of vibrational frequency shifts of carbonyl and nitrile infrared probes by vibrational Stark dipole theory. However, here we show that the nitrile vibrational frequency shift induced by its interaction with the surrounding molecules cannot be solely described by electric field-based theory because of the exchange-repulsion and dispersion interaction contributions. Considering a variety of molecular environments ranging from bulk solutions to protein environments, we explore the distinct scenarios of solute-environment contacts and their traces in vibrational frequency shifts. We believe that the present work could provide a set of clues that could be potentially used to design a rigorous theoretical model linking vibrational solvatochromism and molecular topology in complex heterogeneous environments.

Original languageEnglish
Pages (from-to)18094-18111
Number of pages18
JournalPhysical Chemistry Chemical Physics
Volume18
Issue number27
DOIs
Publication statusPublished - 2016

Fingerprint

Nitriles
nitriles
Vibrational spectra
dipoles
Infrared radiation
probes
frequency shift
Biopolymers
Electric fields
Topology
biopolymers
in situ measurement
Molecules
solutes
Theoretical Models
topology
interactions
Proteins
proteins
electric fields

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Physics and Astronomy(all)

Cite this

Vibrational solvatochromism of nitrile infrared probes : Beyond the vibrational Stark dipole approach. / Błasiak, Bartosz; Ritchie, Andrew W.; Webb, Lauren J.; Cho, Minhaeng.

In: Physical Chemistry Chemical Physics, Vol. 18, No. 27, 2016, p. 18094-18111.

Research output: Contribution to journalArticle

Błasiak, Bartosz ; Ritchie, Andrew W. ; Webb, Lauren J. ; Cho, Minhaeng. / Vibrational solvatochromism of nitrile infrared probes : Beyond the vibrational Stark dipole approach. In: Physical Chemistry Chemical Physics. 2016 ; Vol. 18, No. 27. pp. 18094-18111.
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