Viral load dynamics in adult patients with A(H1N1)pdm09 influenza

J. Y. Noh, J. Y. Song, S. Y. Hwang, W. S. Choi, J. Y. Heo, H. J. Cheong, W. J. Kim

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    The dynamics of influenza A viral load in respiratory samples collected from adult A(H1N1)pdm09 influenza patients were investigated. Three respiratory specimens were obtained every 2-4 days and clinical findings were recorded at the time each specimen was collected. A total of 105 serial specimens were collected from 35 patients. Viral clearance was more rapid in patients aged 15-29 years than patients aged 30-49 years (P < 0·01) or ≥50 years (P < 0·01). Hospitalized patients showed slow viral clearance compared to outpatients (P < 0·01). Resolution of cough and headache was correlated with viral load reduction in respiratory specimens. Viral shedding was found in 17 patients (48·6%) 5 days after symptom onset. Time to hospital visit after symptom onset was significantly correlated with prolonged viral shedding (odds ratio 9·0, 95% confidence interval 1·56-51·87, P = 0·01). These findings will contribute to infection control aspects with respect to managing patients with influenza virus infections.

    Original languageEnglish
    Pages (from-to)753-758
    Number of pages6
    JournalEpidemiology and Infection
    Volume142
    Issue number4
    DOIs
    Publication statusPublished - 2014 Apr

    Keywords

    • Influenza A
    • pandemic

    ASJC Scopus subject areas

    • Epidemiology
    • Infectious Diseases

    Fingerprint

    Dive into the research topics of 'Viral load dynamics in adult patients with A(H1N1)pdm09 influenza'. Together they form a unique fingerprint.

    Cite this