Viral shedding from diverse body fluids in a patient with severe fever with thrombocytopenia syndrome

Eun Ju Jeong, Joon-Young Song, Chae Seung Lim, Ilseob Lee, Man-Seong Park, Min Joo Choi, Ji Ho Jeon, Seong Hui Kang, Bo Kyeung Jung, Jin Gu Yoon, Hak Jun Hyun, Ji Yun Noh, Hee-Jin Cheong, Woo Joo Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne disease characterized by high fever, thrombocytopenia, leukopenia, and multiple organ failure and is caused by a novel bunyavirus. Human-to-human transmission has been reported previously, but the mode of transmission has not been clarified thoroughly. Study design: We identified a case of a 73-year-old woman with SFTS and performed a semi-quantitative real-time reverse transcription PCR (real-time RT-PCR) assay on her blood, tracheal aspirate, gastric aspirate and urine to detect SFTS virus (SFTSV). Results: During 7-day hospitalization, all the serum samples showed positive Ct values lower than 35 in both the S and M segments, suggesting the presence of the SFTSV RNA. After initiation of plasma exchange, serum SFTSV load markedly decreased, but still remained positive. The SFTS viral RNA was also detected in other body fluids, including tracheal aspirate and gastric aspirate. Conclusion: These results suggest that droplet transmission can occur through close contact with infected patients.

Original languageEnglish
Pages (from-to)33-35
Number of pages3
JournalJournal of Clinical Virology
Volume80
DOIs
Publication statusPublished - 2016 Jul 1

Fingerprint

Virus Shedding
Body Fluids
Thrombocytopenia
Fever
Stomach
Orthobunyavirus
Tick-Borne Diseases
Plasma Exchange
Multiple Organ Failure
Leukopenia
Viral RNA
Serum
Reverse Transcription
Real-Time Polymerase Chain Reaction
Hospitalization
Urine
RNA
Viruses
Polymerase Chain Reaction

Keywords

  • Bunyaviridae infections
  • Disease transmission
  • Phlebovirus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Viral shedding from diverse body fluids in a patient with severe fever with thrombocytopenia syndrome. / Jeong, Eun Ju; Song, Joon-Young; Lim, Chae Seung; Lee, Ilseob; Park, Man-Seong; Choi, Min Joo; Jeon, Ji Ho; Kang, Seong Hui; Jung, Bo Kyeung; Yoon, Jin Gu; Hyun, Hak Jun; Noh, Ji Yun; Cheong, Hee-Jin; Kim, Woo Joo.

In: Journal of Clinical Virology, Vol. 80, 01.07.2016, p. 33-35.

Research output: Contribution to journalArticle

Jeong, Eun Ju ; Song, Joon-Young ; Lim, Chae Seung ; Lee, Ilseob ; Park, Man-Seong ; Choi, Min Joo ; Jeon, Ji Ho ; Kang, Seong Hui ; Jung, Bo Kyeung ; Yoon, Jin Gu ; Hyun, Hak Jun ; Noh, Ji Yun ; Cheong, Hee-Jin ; Kim, Woo Joo. / Viral shedding from diverse body fluids in a patient with severe fever with thrombocytopenia syndrome. In: Journal of Clinical Virology. 2016 ; Vol. 80. pp. 33-35.
@article{7c1c19104bc1428c86aa1863d400f7b4,
title = "Viral shedding from diverse body fluids in a patient with severe fever with thrombocytopenia syndrome",
abstract = "Background: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne disease characterized by high fever, thrombocytopenia, leukopenia, and multiple organ failure and is caused by a novel bunyavirus. Human-to-human transmission has been reported previously, but the mode of transmission has not been clarified thoroughly. Study design: We identified a case of a 73-year-old woman with SFTS and performed a semi-quantitative real-time reverse transcription PCR (real-time RT-PCR) assay on her blood, tracheal aspirate, gastric aspirate and urine to detect SFTS virus (SFTSV). Results: During 7-day hospitalization, all the serum samples showed positive Ct values lower than 35 in both the S and M segments, suggesting the presence of the SFTSV RNA. After initiation of plasma exchange, serum SFTSV load markedly decreased, but still remained positive. The SFTS viral RNA was also detected in other body fluids, including tracheal aspirate and gastric aspirate. Conclusion: These results suggest that droplet transmission can occur through close contact with infected patients.",
keywords = "Bunyaviridae infections, Disease transmission, Phlebovirus",
author = "Jeong, {Eun Ju} and Joon-Young Song and Lim, {Chae Seung} and Ilseob Lee and Man-Seong Park and Choi, {Min Joo} and Jeon, {Ji Ho} and Kang, {Seong Hui} and Jung, {Bo Kyeung} and Yoon, {Jin Gu} and Hyun, {Hak Jun} and Noh, {Ji Yun} and Hee-Jin Cheong and Kim, {Woo Joo}",
year = "2016",
month = "7",
day = "1",
doi = "10.1016/j.jcv.2016.04.018",
language = "English",
volume = "80",
pages = "33--35",
journal = "Journal of Clinical Virology",
issn = "1386-6532",
publisher = "Elsevier",

}

TY - JOUR

T1 - Viral shedding from diverse body fluids in a patient with severe fever with thrombocytopenia syndrome

AU - Jeong, Eun Ju

AU - Song, Joon-Young

AU - Lim, Chae Seung

AU - Lee, Ilseob

AU - Park, Man-Seong

AU - Choi, Min Joo

AU - Jeon, Ji Ho

AU - Kang, Seong Hui

AU - Jung, Bo Kyeung

AU - Yoon, Jin Gu

AU - Hyun, Hak Jun

AU - Noh, Ji Yun

AU - Cheong, Hee-Jin

AU - Kim, Woo Joo

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Background: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne disease characterized by high fever, thrombocytopenia, leukopenia, and multiple organ failure and is caused by a novel bunyavirus. Human-to-human transmission has been reported previously, but the mode of transmission has not been clarified thoroughly. Study design: We identified a case of a 73-year-old woman with SFTS and performed a semi-quantitative real-time reverse transcription PCR (real-time RT-PCR) assay on her blood, tracheal aspirate, gastric aspirate and urine to detect SFTS virus (SFTSV). Results: During 7-day hospitalization, all the serum samples showed positive Ct values lower than 35 in both the S and M segments, suggesting the presence of the SFTSV RNA. After initiation of plasma exchange, serum SFTSV load markedly decreased, but still remained positive. The SFTS viral RNA was also detected in other body fluids, including tracheal aspirate and gastric aspirate. Conclusion: These results suggest that droplet transmission can occur through close contact with infected patients.

AB - Background: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne disease characterized by high fever, thrombocytopenia, leukopenia, and multiple organ failure and is caused by a novel bunyavirus. Human-to-human transmission has been reported previously, but the mode of transmission has not been clarified thoroughly. Study design: We identified a case of a 73-year-old woman with SFTS and performed a semi-quantitative real-time reverse transcription PCR (real-time RT-PCR) assay on her blood, tracheal aspirate, gastric aspirate and urine to detect SFTS virus (SFTSV). Results: During 7-day hospitalization, all the serum samples showed positive Ct values lower than 35 in both the S and M segments, suggesting the presence of the SFTSV RNA. After initiation of plasma exchange, serum SFTSV load markedly decreased, but still remained positive. The SFTS viral RNA was also detected in other body fluids, including tracheal aspirate and gastric aspirate. Conclusion: These results suggest that droplet transmission can occur through close contact with infected patients.

KW - Bunyaviridae infections

KW - Disease transmission

KW - Phlebovirus

UR - http://www.scopus.com/inward/record.url?scp=84964491341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964491341&partnerID=8YFLogxK

U2 - 10.1016/j.jcv.2016.04.018

DO - 10.1016/j.jcv.2016.04.018

M3 - Article

C2 - 27135388

AN - SCOPUS:84964491341

VL - 80

SP - 33

EP - 35

JO - Journal of Clinical Virology

JF - Journal of Clinical Virology

SN - 1386-6532

ER -