Virus-Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes

Yoosoo Yang, Yeonsun Hong, Gi Hoon Nam, Jin Hwa Chung, Eunee Koh, In-San Kim

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

A study investigates a new biocompatible nanoplatform using an engineered exosome to transfer functional membrane proteins directly into cellular membranes. This modification of plasma membranes is called ‘membrane-editing’. The biologically originated factors promoting fusion, such as viral fusion components on the exosome surfaces, are valid biochemical techniques that give rise to high fusion efficiencies. The study has used vascular stomatitis virus (VSV)-G protein, which is routinely used to enhance the target range and transduction efficiency of retroviruses by providing wider tropism, improving viral stability, and augmenting resistance to complement inactivation. The VSV-G protein is a low-pH-activated viral fusogen that enables highly effective membrane fusion without adverse effects.

Original languageEnglish
Article number1605604
JournalAdvanced Materials
Volume29
Issue number13
DOIs
Publication statusPublished - 2017 Apr 4

Keywords

  • exosomes
  • membrane protein
  • nanoplatform
  • viral fusogen

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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