Viscoelastic lithography for fabricating self-organizing soft micro-honeycomb structures with ultra-high aspect ratios

Gi Seok Jeong, Da Yoon No, Jaeseo Lee, Junghyo Yoon, Seok Chung, Sang Hoon Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

High-aspect ratio micro- and nano-structures have been used for the production of a variety of applications. In this paper, we describe a simple and cost-effective approach to fabricate an arrayed microarchitecture with an ultra-high aspect ratio using soft materials. The shapes and sizes of the honeycomb structure can be easily modulated by changing the dimensions and position of the base mould pattern and the pressure. The honeycomb structure is used to prepare a drug delivery patch and a microwell array to form cell spheroids without cell loss. The honeycomb structures prepared using natural ECM (collagen-Matrigel) materials are successfully fabricated. The hepatocytes and endothelial cells are seeded and co-cultured in the ECM-based micro-honeycomb to prepare a 3D liver model successfully mimicking an ultrastructure of liver and providing enhanced liver function.

Original languageEnglish
Article number11269
JournalNature Communications
Volume7
DOIs
Publication statusPublished - 2016 May 9

Fingerprint

Honeycomb structures
honeycomb structures
organizing
high aspect ratio
liver
Liver
Lithography
Military electronic countermeasures
Aspect ratio
lithography
spheroids
Endothelial cells
collagens
cells
Drug delivery
Hepatocytes
delivery
drugs
Fungi
Collagen

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Viscoelastic lithography for fabricating self-organizing soft micro-honeycomb structures with ultra-high aspect ratios. / Jeong, Gi Seok; No, Da Yoon; Lee, Jaeseo; Yoon, Junghyo; Chung, Seok; Lee, Sang Hoon.

In: Nature Communications, Vol. 7, 11269, 09.05.2016.

Research output: Contribution to journalArticle

@article{6210f40ee3074e29986ccdcb282bdbeb,
title = "Viscoelastic lithography for fabricating self-organizing soft micro-honeycomb structures with ultra-high aspect ratios",
abstract = "High-aspect ratio micro- and nano-structures have been used for the production of a variety of applications. In this paper, we describe a simple and cost-effective approach to fabricate an arrayed microarchitecture with an ultra-high aspect ratio using soft materials. The shapes and sizes of the honeycomb structure can be easily modulated by changing the dimensions and position of the base mould pattern and the pressure. The honeycomb structure is used to prepare a drug delivery patch and a microwell array to form cell spheroids without cell loss. The honeycomb structures prepared using natural ECM (collagen-Matrigel) materials are successfully fabricated. The hepatocytes and endothelial cells are seeded and co-cultured in the ECM-based micro-honeycomb to prepare a 3D liver model successfully mimicking an ultrastructure of liver and providing enhanced liver function.",
author = "Jeong, {Gi Seok} and No, {Da Yoon} and Jaeseo Lee and Junghyo Yoon and Seok Chung and Lee, {Sang Hoon}",
year = "2016",
month = "5",
day = "9",
doi = "10.1038/ncomms11269",
language = "English",
volume = "7",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Viscoelastic lithography for fabricating self-organizing soft micro-honeycomb structures with ultra-high aspect ratios

AU - Jeong, Gi Seok

AU - No, Da Yoon

AU - Lee, Jaeseo

AU - Yoon, Junghyo

AU - Chung, Seok

AU - Lee, Sang Hoon

PY - 2016/5/9

Y1 - 2016/5/9

N2 - High-aspect ratio micro- and nano-structures have been used for the production of a variety of applications. In this paper, we describe a simple and cost-effective approach to fabricate an arrayed microarchitecture with an ultra-high aspect ratio using soft materials. The shapes and sizes of the honeycomb structure can be easily modulated by changing the dimensions and position of the base mould pattern and the pressure. The honeycomb structure is used to prepare a drug delivery patch and a microwell array to form cell spheroids without cell loss. The honeycomb structures prepared using natural ECM (collagen-Matrigel) materials are successfully fabricated. The hepatocytes and endothelial cells are seeded and co-cultured in the ECM-based micro-honeycomb to prepare a 3D liver model successfully mimicking an ultrastructure of liver and providing enhanced liver function.

AB - High-aspect ratio micro- and nano-structures have been used for the production of a variety of applications. In this paper, we describe a simple and cost-effective approach to fabricate an arrayed microarchitecture with an ultra-high aspect ratio using soft materials. The shapes and sizes of the honeycomb structure can be easily modulated by changing the dimensions and position of the base mould pattern and the pressure. The honeycomb structure is used to prepare a drug delivery patch and a microwell array to form cell spheroids without cell loss. The honeycomb structures prepared using natural ECM (collagen-Matrigel) materials are successfully fabricated. The hepatocytes and endothelial cells are seeded and co-cultured in the ECM-based micro-honeycomb to prepare a 3D liver model successfully mimicking an ultrastructure of liver and providing enhanced liver function.

UR - http://www.scopus.com/inward/record.url?scp=84971255177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84971255177&partnerID=8YFLogxK

U2 - 10.1038/ncomms11269

DO - 10.1038/ncomms11269

M3 - Article

AN - SCOPUS:84971255177

VL - 7

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 11269

ER -