Visfatin induces sickness responses in the brain

Byong Seo Park, Sung Ho Jin, Joong Jean Park, Jeong Woo Park, I. L. Seong Namgoong, Young I.L. Kim, Byung Ju Lee, Jae Geun Kim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background/Objective: Visfatin, also known as nicotiamide phosphoribosyltransferase or pre-B cell colony enhancing factor, is a pro-inflammatory cytokine whose serum level is increased in sepsis and cancer as well as in obesity. Here we report a pro-inflammatory role of visfatin in the brain, to mediate sickness responses including anorexia, hyperthermia and hypoactivity. Methodology: Rats were intracerebroventricularly (ICV) injected with visfatin, and changes in food intake, body weight, body temperature and locomotor activity were monitored. Real-time PCR was applied to determine the expressions of proinflammatory cytokines, proopiomelanocortin (POMC) and prostaglandin-synthesizing enzymes in their brain. To determine the roles of cyclooxygenase (COX) and melanocortin in the visfatin action, rats were ICV-injected with visfatin with or without SHU9119, a melanocortin receptor antagonist, or indomethacin, a COX inhibitor, and their sickness behaviors were evaluated. Principal Findings: Administration of visfatin decreased food intake, body weight and locomotor activity and increased body temperature. Visfatin evoked significant increases in the levels of pro-inflammatory cytokines, prostaglandinsynthesizing enzymes and POMC, an anorexigenic neuropeptide. Indomethacin attenuated the effects of visfatin on hyperthermia and hypoactivity, but not anorexia. Further, SHU9119 blocked visfatin-induced anorexia but did not affect hyperthermia or hypoactivity. Conclusions: Visfatin induced sickness responses via regulation of COX and the melanocortin pathway in the brain.

Original languageEnglish
Article numbere15981
JournalPLoS One
Volume6
Issue number1
DOIs
Publication statusPublished - 2011 Feb 3

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nicotinamide phosphoribosyltransferase
Nicotinamide Phosphoribosyltransferase
Brain
brain
prostaglandin synthase
anorexia
Anorexia
pro-opiomelanocortin
fever
Melanocortins
cytokines
indomethacin
Pro-Opiomelanocortin
Fever
Locomotion
Prostaglandin-Endoperoxide Synthases
Cytokines
body temperature
Body Temperature
locomotion

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Park, B. S., Jin, S. H., Park, J. J., Park, J. W., Seong Namgoong, I. L., Kim, Y. I. L., ... Kim, J. G. (2011). Visfatin induces sickness responses in the brain. PLoS One, 6(1), [e15981]. https://doi.org/10.1371/journal.pone.0015981

Visfatin induces sickness responses in the brain. / Park, Byong Seo; Jin, Sung Ho; Park, Joong Jean; Park, Jeong Woo; Seong Namgoong, I. L.; Kim, Young I.L.; Lee, Byung Ju; Kim, Jae Geun.

In: PLoS One, Vol. 6, No. 1, e15981, 03.02.2011.

Research output: Contribution to journalArticle

Park, BS, Jin, SH, Park, JJ, Park, JW, Seong Namgoong, IL, Kim, YIL, Lee, BJ & Kim, JG 2011, 'Visfatin induces sickness responses in the brain', PLoS One, vol. 6, no. 1, e15981. https://doi.org/10.1371/journal.pone.0015981
Park BS, Jin SH, Park JJ, Park JW, Seong Namgoong IL, Kim YIL et al. Visfatin induces sickness responses in the brain. PLoS One. 2011 Feb 3;6(1). e15981. https://doi.org/10.1371/journal.pone.0015981
Park, Byong Seo ; Jin, Sung Ho ; Park, Joong Jean ; Park, Jeong Woo ; Seong Namgoong, I. L. ; Kim, Young I.L. ; Lee, Byung Ju ; Kim, Jae Geun. / Visfatin induces sickness responses in the brain. In: PLoS One. 2011 ; Vol. 6, No. 1.
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