Vitamin C increases the fecal fat excretion by chitosan in guinea-pigs, thereby reducing body weight gain

S. C. Jun, E. Y. Jung, D. H. Kang, J. M. Kim, U. J. Chang, Hyung Joo Suh

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The aims of this study were to investigate the antiobesity properties of chitosan on its own, as well as in the presence of vitamin C, in vivo. Hartley guinea-pigs were divided into Control (normal diet), F-control (high fat diet), Chitosan (high fat diet with 5.0% chitosan) and Chito-vit C (high fat diet with 5.0% chitosan containing 0.5% vitamin C) groups, respectively. The effects of chitosan, both alone and in the presence of vitamin C, on body weight, total fecal weight, fecal composition and plasma lipid level were studied for 5 weeks. The results of this study indicated that the fat-binding and water-holding capacity of chitosan might decrease body weight by reducing the absorption of cholesterol and fat, subsequently increasing total fecal weight, fecal fat excretion and fecal water excretion. Vitamin C increased the fecal fat excretion by chitosan in guinea-pigs, thereby reducing body weight gain.

Original languageEnglish
Pages (from-to)1234-1241
Number of pages8
JournalPhytotherapy Research
Volume24
Issue number8
DOIs
Publication statusPublished - 2010 Aug

Keywords

  • Antiobesity
  • Chitosan
  • Fecal excretion
  • Guinea-pig
  • Vitamin C

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Vitamin C increases the fecal fat excretion by chitosan in guinea-pigs, thereby reducing body weight gain'. Together they form a unique fingerprint.

  • Cite this