Vitamin D levels in allergic rhinitis: a systematic review and meta-analysis

Yoon Hee Kim, Kyung Won Kim, Min Jung Kim, In Suk Sol, Seo Hee Yoon, Hyeong Sik Ahn, Hyun Jung Kim, Myung Hyun Sohn, Kyu Earn Kim

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: We aimed to systematically review observational studies investigating the relationship between vitamin D levels and allergic rhinitis (AR). Methods: Studies were selected if they evaluated the relationship between vitamin D levels and AR, and included studies that evaluated other allergic conditions if those studies also contained data on AR. We assessed the incidence and prevalence of AR according to vitamin D levels and compared vitamin D levels in patients with AR to levels in controls. Results: Nineteen studies were selected. Of these, only seven focused solely on AR; 10 studies evaluated the other allergic diseases as well as AR; and two studies evaluated asthma primarily, but also included data on patients with AR. The pooled odds ratios (ORs) for the incidence of AR according to vitamin D levels were not statistically significant for either children or adults. Lower vitamin D levels were associated with a higher AR prevalence only in children (pooled OR [95% confidence interval (CI)], 0.75 [0.58, 0.98]). The pooled mean vitamin D level in patients with AR was lower than that of controls only in children (pooled means difference [95% CI], −7.63 [−13.08, −2.18]). Conclusions: Prior vitamin D levels were not related to developing AR, but lower vitamin D levels were associated with a higher AR prevalence only in children. There is insufficient evidence to support vitamin D supplementation for AR prevention. However, physicians should consider evaluating patients for vitamin D deficiency during AR management, especially in children.

Original languageEnglish
Pages (from-to)580-590
Number of pages11
JournalPediatric Allergy and Immunology
Volume27
Issue number6
DOIs
Publication statusPublished - 2016 Sep 1

Fingerprint

Vitamin D
Meta-Analysis
Allergic Rhinitis
Odds Ratio
Confidence Intervals
Vitamin D Deficiency
Incidence
Observational Studies
Asthma

Keywords

  • allergic rhinitis
  • children
  • incidence
  • prevalence
  • vitamin D

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology

Cite this

Kim, Y. H., Kim, K. W., Kim, M. J., Sol, I. S., Yoon, S. H., Ahn, H. S., ... Kim, K. E. (2016). Vitamin D levels in allergic rhinitis: a systematic review and meta-analysis. Pediatric Allergy and Immunology, 27(6), 580-590. https://doi.org/10.1111/pai.12599

Vitamin D levels in allergic rhinitis : a systematic review and meta-analysis. / Kim, Yoon Hee; Kim, Kyung Won; Kim, Min Jung; Sol, In Suk; Yoon, Seo Hee; Ahn, Hyeong Sik; Kim, Hyun Jung; Sohn, Myung Hyun; Kim, Kyu Earn.

In: Pediatric Allergy and Immunology, Vol. 27, No. 6, 01.09.2016, p. 580-590.

Research output: Contribution to journalArticle

Kim, YH, Kim, KW, Kim, MJ, Sol, IS, Yoon, SH, Ahn, HS, Kim, HJ, Sohn, MH & Kim, KE 2016, 'Vitamin D levels in allergic rhinitis: a systematic review and meta-analysis', Pediatric Allergy and Immunology, vol. 27, no. 6, pp. 580-590. https://doi.org/10.1111/pai.12599
Kim, Yoon Hee ; Kim, Kyung Won ; Kim, Min Jung ; Sol, In Suk ; Yoon, Seo Hee ; Ahn, Hyeong Sik ; Kim, Hyun Jung ; Sohn, Myung Hyun ; Kim, Kyu Earn. / Vitamin D levels in allergic rhinitis : a systematic review and meta-analysis. In: Pediatric Allergy and Immunology. 2016 ; Vol. 27, No. 6. pp. 580-590.
@article{ba0dfd9e5b0d4429956eb0c7f9a0270a,
title = "Vitamin D levels in allergic rhinitis: a systematic review and meta-analysis",
abstract = "Background: We aimed to systematically review observational studies investigating the relationship between vitamin D levels and allergic rhinitis (AR). Methods: Studies were selected if they evaluated the relationship between vitamin D levels and AR, and included studies that evaluated other allergic conditions if those studies also contained data on AR. We assessed the incidence and prevalence of AR according to vitamin D levels and compared vitamin D levels in patients with AR to levels in controls. Results: Nineteen studies were selected. Of these, only seven focused solely on AR; 10 studies evaluated the other allergic diseases as well as AR; and two studies evaluated asthma primarily, but also included data on patients with AR. The pooled odds ratios (ORs) for the incidence of AR according to vitamin D levels were not statistically significant for either children or adults. Lower vitamin D levels were associated with a higher AR prevalence only in children (pooled OR [95{\%} confidence interval (CI)], 0.75 [0.58, 0.98]). The pooled mean vitamin D level in patients with AR was lower than that of controls only in children (pooled means difference [95{\%} CI], −7.63 [−13.08, −2.18]). Conclusions: Prior vitamin D levels were not related to developing AR, but lower vitamin D levels were associated with a higher AR prevalence only in children. There is insufficient evidence to support vitamin D supplementation for AR prevention. However, physicians should consider evaluating patients for vitamin D deficiency during AR management, especially in children.",
keywords = "allergic rhinitis, children, incidence, prevalence, vitamin D",
author = "Kim, {Yoon Hee} and Kim, {Kyung Won} and Kim, {Min Jung} and Sol, {In Suk} and Yoon, {Seo Hee} and Ahn, {Hyeong Sik} and Kim, {Hyun Jung} and Sohn, {Myung Hyun} and Kim, {Kyu Earn}",
year = "2016",
month = "9",
day = "1",
doi = "10.1111/pai.12599",
language = "English",
volume = "27",
pages = "580--590",
journal = "Pediatric Allergy and Immunology",
issn = "0905-6157",
publisher = "Blackwell Munksgaard",
number = "6",

}

TY - JOUR

T1 - Vitamin D levels in allergic rhinitis

T2 - a systematic review and meta-analysis

AU - Kim, Yoon Hee

AU - Kim, Kyung Won

AU - Kim, Min Jung

AU - Sol, In Suk

AU - Yoon, Seo Hee

AU - Ahn, Hyeong Sik

AU - Kim, Hyun Jung

AU - Sohn, Myung Hyun

AU - Kim, Kyu Earn

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Background: We aimed to systematically review observational studies investigating the relationship between vitamin D levels and allergic rhinitis (AR). Methods: Studies were selected if they evaluated the relationship between vitamin D levels and AR, and included studies that evaluated other allergic conditions if those studies also contained data on AR. We assessed the incidence and prevalence of AR according to vitamin D levels and compared vitamin D levels in patients with AR to levels in controls. Results: Nineteen studies were selected. Of these, only seven focused solely on AR; 10 studies evaluated the other allergic diseases as well as AR; and two studies evaluated asthma primarily, but also included data on patients with AR. The pooled odds ratios (ORs) for the incidence of AR according to vitamin D levels were not statistically significant for either children or adults. Lower vitamin D levels were associated with a higher AR prevalence only in children (pooled OR [95% confidence interval (CI)], 0.75 [0.58, 0.98]). The pooled mean vitamin D level in patients with AR was lower than that of controls only in children (pooled means difference [95% CI], −7.63 [−13.08, −2.18]). Conclusions: Prior vitamin D levels were not related to developing AR, but lower vitamin D levels were associated with a higher AR prevalence only in children. There is insufficient evidence to support vitamin D supplementation for AR prevention. However, physicians should consider evaluating patients for vitamin D deficiency during AR management, especially in children.

AB - Background: We aimed to systematically review observational studies investigating the relationship between vitamin D levels and allergic rhinitis (AR). Methods: Studies were selected if they evaluated the relationship between vitamin D levels and AR, and included studies that evaluated other allergic conditions if those studies also contained data on AR. We assessed the incidence and prevalence of AR according to vitamin D levels and compared vitamin D levels in patients with AR to levels in controls. Results: Nineteen studies were selected. Of these, only seven focused solely on AR; 10 studies evaluated the other allergic diseases as well as AR; and two studies evaluated asthma primarily, but also included data on patients with AR. The pooled odds ratios (ORs) for the incidence of AR according to vitamin D levels were not statistically significant for either children or adults. Lower vitamin D levels were associated with a higher AR prevalence only in children (pooled OR [95% confidence interval (CI)], 0.75 [0.58, 0.98]). The pooled mean vitamin D level in patients with AR was lower than that of controls only in children (pooled means difference [95% CI], −7.63 [−13.08, −2.18]). Conclusions: Prior vitamin D levels were not related to developing AR, but lower vitamin D levels were associated with a higher AR prevalence only in children. There is insufficient evidence to support vitamin D supplementation for AR prevention. However, physicians should consider evaluating patients for vitamin D deficiency during AR management, especially in children.

KW - allergic rhinitis

KW - children

KW - incidence

KW - prevalence

KW - vitamin D

UR - http://www.scopus.com/inward/record.url?scp=84983247207&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983247207&partnerID=8YFLogxK

U2 - 10.1111/pai.12599

DO - 10.1111/pai.12599

M3 - Article

C2 - 27188226

AN - SCOPUS:84983247207

VL - 27

SP - 580

EP - 590

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

SN - 0905-6157

IS - 6

ER -