Vitamin D receptor ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis susceptibility: A meta-analysis

Young Ho Lee, Sung Jae Choi, Jong Dae Ji, Gwan Gyu Song

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)

    Abstract

    The aim of this study was to explore whether vitamin D receptor (VDR) polymorphisms confer susceptibility to psoriasis. Meta-analyses were conducted on the associations between the VDR ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis. Nine relevant studies on VDR polymorphisms and psoriasis were included in this meta-analysis, which involved 742 psoriasis patients and 715 controls. Meta-analysis indicated an association between the VDR ApaI A allele and psoriasis in Turkish studies (OR = 0.684, 95% CI = 0.475-0.985, p = 0.041). Meta-analysis indicated an association between the BsmI B allele and psoriasis in Asians (OR = 0.636, 95% CI = 0.411-0.984, p = 0.041), and showed a significant association between the FF and ff genotypes of the FokI polymorphism and psoriasis in all study subjects and in Turkish studies (OR = 2.028, 95% CI = 1.194-3.446, p = 0.009; OR = 3.582, 95% CI = 1.602-8.009, p = 0.002). This meta-analysis suggests that the VDR ApaI polymorphism confers susceptibility to psoriasis in the Turkish population. In addition, associations were found between the BsmI polymorphism and susceptibility to psoriasis in Asians and between the Fok I polymorphism and psoriasis in the Turkish population.

    Original languageEnglish
    Pages (from-to)6471-6478
    Number of pages8
    JournalMolecular biology reports
    Volume39
    Issue number6
    DOIs
    Publication statusPublished - 2012 Jun

    Keywords

    • Meta-analysis
    • Polymorphism
    • Psoriasis
    • Vitamin D receptor

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics

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