Abstract
Background: Vitamin D is considered a regulator of the immune system, and its polymorphisms have been associated with psoriasis in some but not all reports. Aim: To explore whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to psoriasis. Methods: Meta-analyses were conducted to determine the associations between psoriasis and the VDR ApaI, TaqI, BsmI and FokI polymorphisms in all participants, and stratified by ethnic group. Results: In total, 16 studies on VDR polymorphisms and psoriasis were included in this meta-analysis, which involved 2086 patients and 2182 controls. The meta-analysis indicated an association between psoriasis and the VDR TaqI TT genotype in Caucasian (OR = 1.29, 95% CI = 1.00–1.66, P < 0.05), but not in Asian (OR = 1.32, 95% CI = 0.89–1.96, P = 0.16) populations. However, no association was found between psoriasis and the VDR TaqI polymorphism using dominant, allele contrast or homozygous contrast models. No association was found between psoriasis and either the VDR ApaI, BsmI or FokI polymorphisms by meta-analyses of the allele contrast, recessive, or dominant models or homozygous contrast models in the overall, Caucasian or Asian populations. Conclusion: This meta-analysis showed that polymorphisms in VDR ApaI, BsmI and FokI are not associated with psoriasis susceptibility in overall, Caucasian or Asian populations. However, the VDR TaqI polymorphism is associated with psoriasis susceptibility in Caucasian populations.
| Original language | English |
|---|---|
| Journal | Clinical and Experimental Dermatology |
| DOIs | |
| Publication status | Accepted/In press - 2018 Jan 1 |
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ASJC Scopus subject areas
- Dermatology
Cite this
Vitamin D receptor ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis susceptibility : an updated meta-analysis. / Lee, Young Ho.
In: Clinical and Experimental Dermatology, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vitamin D receptor ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis susceptibility
T2 - an updated meta-analysis
AU - Lee, Young Ho
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: Vitamin D is considered a regulator of the immune system, and its polymorphisms have been associated with psoriasis in some but not all reports. Aim: To explore whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to psoriasis. Methods: Meta-analyses were conducted to determine the associations between psoriasis and the VDR ApaI, TaqI, BsmI and FokI polymorphisms in all participants, and stratified by ethnic group. Results: In total, 16 studies on VDR polymorphisms and psoriasis were included in this meta-analysis, which involved 2086 patients and 2182 controls. The meta-analysis indicated an association between psoriasis and the VDR TaqI TT genotype in Caucasian (OR = 1.29, 95% CI = 1.00–1.66, P < 0.05), but not in Asian (OR = 1.32, 95% CI = 0.89–1.96, P = 0.16) populations. However, no association was found between psoriasis and the VDR TaqI polymorphism using dominant, allele contrast or homozygous contrast models. No association was found between psoriasis and either the VDR ApaI, BsmI or FokI polymorphisms by meta-analyses of the allele contrast, recessive, or dominant models or homozygous contrast models in the overall, Caucasian or Asian populations. Conclusion: This meta-analysis showed that polymorphisms in VDR ApaI, BsmI and FokI are not associated with psoriasis susceptibility in overall, Caucasian or Asian populations. However, the VDR TaqI polymorphism is associated with psoriasis susceptibility in Caucasian populations.
AB - Background: Vitamin D is considered a regulator of the immune system, and its polymorphisms have been associated with psoriasis in some but not all reports. Aim: To explore whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to psoriasis. Methods: Meta-analyses were conducted to determine the associations between psoriasis and the VDR ApaI, TaqI, BsmI and FokI polymorphisms in all participants, and stratified by ethnic group. Results: In total, 16 studies on VDR polymorphisms and psoriasis were included in this meta-analysis, which involved 2086 patients and 2182 controls. The meta-analysis indicated an association between psoriasis and the VDR TaqI TT genotype in Caucasian (OR = 1.29, 95% CI = 1.00–1.66, P < 0.05), but not in Asian (OR = 1.32, 95% CI = 0.89–1.96, P = 0.16) populations. However, no association was found between psoriasis and the VDR TaqI polymorphism using dominant, allele contrast or homozygous contrast models. No association was found between psoriasis and either the VDR ApaI, BsmI or FokI polymorphisms by meta-analyses of the allele contrast, recessive, or dominant models or homozygous contrast models in the overall, Caucasian or Asian populations. Conclusion: This meta-analysis showed that polymorphisms in VDR ApaI, BsmI and FokI are not associated with psoriasis susceptibility in overall, Caucasian or Asian populations. However, the VDR TaqI polymorphism is associated with psoriasis susceptibility in Caucasian populations.
UR - http://www.scopus.com/inward/record.url?scp=85057100898&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85057100898&partnerID=8YFLogxK
U2 - 10.1111/ced.13823
DO - 10.1111/ced.13823
M3 - Article
C2 - 30474246
AN - SCOPUS:85057100898
JO - Clinical and Experimental Dermatology
JF - Clinical and Experimental Dermatology
SN - 0307-6938
ER -