Vitamin D receptor Fokl, BsmI, TaqI, Apal, and EcoRV polymorphisms and susceptibility to melanoma: A metaanalysis

Purpose: The purpose of this study was to examine wheth-er vitamin D receptor (VDR) polymorphisms are associated with susceptibility to melanoma. Methods: A meta-analysis was carried out to investigate the association between the VDR Fokl, BsmI, TaqI, Apal, and EcoRV polymorphisms and susceptibility to melanoma. Results: A total of 11 studies were evaluated, which included 4,413 patients and 4,072 controls (all European). The meta-analysis revealed no association between melanoma and the BsmI B allele (odds ratio/OR=0.901, 95% confidence interval/CI=0.783-1.036, p=0.144). However, an association was shown between melanoma and the Bb+bb genotype (QR=0.868, 95% CI=0.767-0.982, p=0.025). No role in the development of melanoma, and genetic factors are considered to contribute to its development [1], Although the primary function of vitamin D involves the maintenance of bone mineral homeostasis, it is also involved in interleukin (IL)-2 inhibition, antibody production, and lymphocyte proliferation [2], It has been reported that 1,25-di- hydroxy vitamin D3 (l,25(OH)2 D3) inhibits interferon secretion and negatively regulates IL-12 association was noticed between melanoma and Fokl polymorphism (OR for the F allele=1.016, 95% 01=0.869-1.189, p=0.839). Moreover, melanoma risk was not associated with the TaqI, Apal, and EcoRV polymorphisms (OR for the T allele=0.986, 95% 01=0.842-1.156, p=0.864; OR for the A allele=0.949, 95% 01=0.842-1.069, p=0.388; OR for the E allele=0.993, 95% 01=0.875-1.126, p=0.9U, respectively). Conclusions: This meta-analysis demonstrated that the VDR BsmI polymorphism is associated with susceptibility to melanoma in Europeans, suggesting that carrying the VDR BsmI B allele may be a protective factor against melanoma development.