Vitamin D receptor polymorphisms and susceptibility to Parkinson’s disease and Alzheimer’s disease

a meta-analysis

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The goal of this study was to examine whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to Parkinson’s disease (PD) and Alzheimer’s disease (AD). A meta-analysis was performed to investigate the association between VDR FokI, BsmI, TaqI, ApaI, rs4334089, or rs11568820 polymorphism and susceptibility to PD or AD. Thirteen studies, including seven on PD and six on AD, were included in this meta-analysis. The meta-analysis revealed an association between the BB + Bb genotype and PD in the Asian population (OR 0.478, 95 % CI 0.259–0.884, p = 0.018). We also observed a significant association between PD and the FokI F allele (OR 1.413, 95 % CI 1.144–1.746, p = 0.001). Meta-analysis of the A allele, the AA vs. Aa + aa, and the AA vs. aa for the ApaI polymorphism revealed significant associations with AD (OR 0.729, 95 % CI 0.0.591–0.900, p = 0.034; OR 0.591, 95 % CI 0.431–0.810, p = 0.001; OR 0.580, 95 % CI 0.361–0.931, p = 0.024, respectively). This meta-analysis demonstrates that the VDR BsmI polymorphism is associated with PD susceptibility in Asians, and the FokI polymorphism is associated with PD. Furthermore, we identified associations between the VDR TaqI and ApaI polymorphisms and AD susceptibility.

Original languageEnglish
Pages (from-to)1947-1953
Number of pages7
JournalNeurological Sciences
Volume35
Issue number12
DOIs
Publication statusPublished - 2014 Jan 1

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Calcitriol Receptors
Parkinson Disease
Meta-Analysis
Alzheimer Disease
Disease Susceptibility
Alleles
Genotype
Population

Keywords

  • Alzheimer’s disease
  • Meta-analysis
  • Parkinson’s disease
  • Polymorphism
  • Vitamin D receptor

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Vitamin D receptor polymorphisms and susceptibility to Parkinson’s disease and Alzheimer’s disease : a meta-analysis. / Lee, Young Ho; Kim, Jae Hoon; Song, Gwan Gyu.

In: Neurological Sciences, Vol. 35, No. 12, 01.01.2014, p. 1947-1953.

Research output: Contribution to journalArticle

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