Vitamin D receptor TaqI, BsmI and ApaI polymorphisms and osteoarthritis susceptibility: A meta-analysis

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: Genetic factors may play a role in the development of osteoarthritis (OA), and vitamin D receptor (VDR) polymorphisms have been associated with several common diseases including OA by some studies. The aim of this study was to explore whether the VDR polymorphisms confer susceptibility to OA. Methods: We conducted meta-analyses on the associations between the VDR TaqI, BsmI, ApaI polymorphisms and OA using: (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) contrast of homozygotes, using fixed and random effects models. Results: A total of 10 relevant studies on VDR polymorphisms and OA were included in this meta-analysis, which involved in total 1591 OA patients and 1781 controls. Nine studies were performed on VDR TaqI polymorphisms, 6 on VDR BsmI polymorphisms, 5 on VDR ApaI polymorphisms. Accordingly, to our meta-analysis of VDR TaqI polymorphisms, no association was found between OA and the VDR TaqI T allele among in all study subjects (OR = 0.841, 95% CI = 0.663-1.067, p = 0.155). Stratification by ethnicity yielded no association between the VDR TaqI T allele and OA in Europeans or Asians. Moreover, no association was found between OA and the VDR TaqI polymorphisms by the meta-analyses of recessive and dominant models, and contrast of homozygotes. No association was found between OA and the VDR polymorphisms with respect to the BsmI and ApaI polymorphisms by meta-analyses. Conclusions: No association was found between the VDR TaqI, BsmI, or ApaI polymorphisms and OA susceptibility by this meta-analysis, which included 3372 subjects.

Original languageEnglish
Pages (from-to)156-161
Number of pages6
JournalJoint Bone Spine
Volume76
Issue number2
DOIs
Publication statusPublished - 2009 Mar 1

Fingerprint

Calcitriol Receptors
Osteoarthritis
Meta-Analysis
Alleles
Homozygote

Keywords

  • Meta-analysis
  • Osteoarthritis
  • Polymorphism
  • Vitamin D receptor

ASJC Scopus subject areas

  • Rheumatology

Cite this

@article{9e8895a7d1454143ab1fbfdca1ed0655,
title = "Vitamin D receptor TaqI, BsmI and ApaI polymorphisms and osteoarthritis susceptibility: A meta-analysis",
abstract = "Objective: Genetic factors may play a role in the development of osteoarthritis (OA), and vitamin D receptor (VDR) polymorphisms have been associated with several common diseases including OA by some studies. The aim of this study was to explore whether the VDR polymorphisms confer susceptibility to OA. Methods: We conducted meta-analyses on the associations between the VDR TaqI, BsmI, ApaI polymorphisms and OA using: (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) contrast of homozygotes, using fixed and random effects models. Results: A total of 10 relevant studies on VDR polymorphisms and OA were included in this meta-analysis, which involved in total 1591 OA patients and 1781 controls. Nine studies were performed on VDR TaqI polymorphisms, 6 on VDR BsmI polymorphisms, 5 on VDR ApaI polymorphisms. Accordingly, to our meta-analysis of VDR TaqI polymorphisms, no association was found between OA and the VDR TaqI T allele among in all study subjects (OR = 0.841, 95{\%} CI = 0.663-1.067, p = 0.155). Stratification by ethnicity yielded no association between the VDR TaqI T allele and OA in Europeans or Asians. Moreover, no association was found between OA and the VDR TaqI polymorphisms by the meta-analyses of recessive and dominant models, and contrast of homozygotes. No association was found between OA and the VDR polymorphisms with respect to the BsmI and ApaI polymorphisms by meta-analyses. Conclusions: No association was found between the VDR TaqI, BsmI, or ApaI polymorphisms and OA susceptibility by this meta-analysis, which included 3372 subjects.",
keywords = "Meta-analysis, Osteoarthritis, Polymorphism, Vitamin D receptor",
author = "Lee, {Young Ho} and Woo, {Jin Hyun} and Sungjae Choi and Ji, {Jong Dae} and Song, {Gwan Gyu}",
year = "2009",
month = "3",
day = "1",
doi = "10.1016/j.jbspin.2008.06.011",
language = "English",
volume = "76",
pages = "156--161",
journal = "Revue du Rhumatisme (English Edition)",
issn = "1169-8446",
publisher = "Elsevier Masson",
number = "2",

}

TY - JOUR

T1 - Vitamin D receptor TaqI, BsmI and ApaI polymorphisms and osteoarthritis susceptibility

T2 - A meta-analysis

AU - Lee, Young Ho

AU - Woo, Jin Hyun

AU - Choi, Sungjae

AU - Ji, Jong Dae

AU - Song, Gwan Gyu

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Objective: Genetic factors may play a role in the development of osteoarthritis (OA), and vitamin D receptor (VDR) polymorphisms have been associated with several common diseases including OA by some studies. The aim of this study was to explore whether the VDR polymorphisms confer susceptibility to OA. Methods: We conducted meta-analyses on the associations between the VDR TaqI, BsmI, ApaI polymorphisms and OA using: (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) contrast of homozygotes, using fixed and random effects models. Results: A total of 10 relevant studies on VDR polymorphisms and OA were included in this meta-analysis, which involved in total 1591 OA patients and 1781 controls. Nine studies were performed on VDR TaqI polymorphisms, 6 on VDR BsmI polymorphisms, 5 on VDR ApaI polymorphisms. Accordingly, to our meta-analysis of VDR TaqI polymorphisms, no association was found between OA and the VDR TaqI T allele among in all study subjects (OR = 0.841, 95% CI = 0.663-1.067, p = 0.155). Stratification by ethnicity yielded no association between the VDR TaqI T allele and OA in Europeans or Asians. Moreover, no association was found between OA and the VDR TaqI polymorphisms by the meta-analyses of recessive and dominant models, and contrast of homozygotes. No association was found between OA and the VDR polymorphisms with respect to the BsmI and ApaI polymorphisms by meta-analyses. Conclusions: No association was found between the VDR TaqI, BsmI, or ApaI polymorphisms and OA susceptibility by this meta-analysis, which included 3372 subjects.

AB - Objective: Genetic factors may play a role in the development of osteoarthritis (OA), and vitamin D receptor (VDR) polymorphisms have been associated with several common diseases including OA by some studies. The aim of this study was to explore whether the VDR polymorphisms confer susceptibility to OA. Methods: We conducted meta-analyses on the associations between the VDR TaqI, BsmI, ApaI polymorphisms and OA using: (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) contrast of homozygotes, using fixed and random effects models. Results: A total of 10 relevant studies on VDR polymorphisms and OA were included in this meta-analysis, which involved in total 1591 OA patients and 1781 controls. Nine studies were performed on VDR TaqI polymorphisms, 6 on VDR BsmI polymorphisms, 5 on VDR ApaI polymorphisms. Accordingly, to our meta-analysis of VDR TaqI polymorphisms, no association was found between OA and the VDR TaqI T allele among in all study subjects (OR = 0.841, 95% CI = 0.663-1.067, p = 0.155). Stratification by ethnicity yielded no association between the VDR TaqI T allele and OA in Europeans or Asians. Moreover, no association was found between OA and the VDR TaqI polymorphisms by the meta-analyses of recessive and dominant models, and contrast of homozygotes. No association was found between OA and the VDR polymorphisms with respect to the BsmI and ApaI polymorphisms by meta-analyses. Conclusions: No association was found between the VDR TaqI, BsmI, or ApaI polymorphisms and OA susceptibility by this meta-analysis, which included 3372 subjects.

KW - Meta-analysis

KW - Osteoarthritis

KW - Polymorphism

KW - Vitamin D receptor

UR - http://www.scopus.com/inward/record.url?scp=61449104844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61449104844&partnerID=8YFLogxK

U2 - 10.1016/j.jbspin.2008.06.011

DO - 10.1016/j.jbspin.2008.06.011

M3 - Article

C2 - 19073371

AN - SCOPUS:61449104844

VL - 76

SP - 156

EP - 161

JO - Revue du Rhumatisme (English Edition)

JF - Revue du Rhumatisme (English Edition)

SN - 1169-8446

IS - 2

ER -