Abstract
Objective: Genetic factors may play a role in the development of osteoarthritis (OA), and vitamin D receptor (VDR) polymorphisms have been associated with several common diseases including OA by some studies. The aim of this study was to explore whether the VDR polymorphisms confer susceptibility to OA. Methods: We conducted meta-analyses on the associations between the VDR TaqI, BsmI, ApaI polymorphisms and OA using: (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) contrast of homozygotes, using fixed and random effects models. Results: A total of 10 relevant studies on VDR polymorphisms and OA were included in this meta-analysis, which involved in total 1591 OA patients and 1781 controls. Nine studies were performed on VDR TaqI polymorphisms, 6 on VDR BsmI polymorphisms, 5 on VDR ApaI polymorphisms. Accordingly, to our meta-analysis of VDR TaqI polymorphisms, no association was found between OA and the VDR TaqI T allele among in all study subjects (OR = 0.841, 95% CI = 0.663-1.067, p = 0.155). Stratification by ethnicity yielded no association between the VDR TaqI T allele and OA in Europeans or Asians. Moreover, no association was found between OA and the VDR TaqI polymorphisms by the meta-analyses of recessive and dominant models, and contrast of homozygotes. No association was found between OA and the VDR polymorphisms with respect to the BsmI and ApaI polymorphisms by meta-analyses. Conclusions: No association was found between the VDR TaqI, BsmI, or ApaI polymorphisms and OA susceptibility by this meta-analysis, which included 3372 subjects.
| Original language | English |
|---|---|
| Pages (from-to) | 156-161 |
| Number of pages | 6 |
| Journal | Joint Bone Spine |
| Volume | 76 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2009 Mar 1 |
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Keywords
- Meta-analysis
- Osteoarthritis
- Polymorphism
- Vitamin D receptor
ASJC Scopus subject areas
- Rheumatology
Cite this
Vitamin D receptor TaqI, BsmI and ApaI polymorphisms and osteoarthritis susceptibility : A meta-analysis. / Lee, Young Ho; Woo, Jin Hyun; Choi, Sungjae; Ji, Jong Dae; Song, Gwan Gyu.
In: Joint Bone Spine, Vol. 76, No. 2, 01.03.2009, p. 156-161.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vitamin D receptor TaqI, BsmI and ApaI polymorphisms and osteoarthritis susceptibility
T2 - A meta-analysis
AU - Lee, Young Ho
AU - Woo, Jin Hyun
AU - Choi, Sungjae
AU - Ji, Jong Dae
AU - Song, Gwan Gyu
PY - 2009/3/1
Y1 - 2009/3/1
N2 - Objective: Genetic factors may play a role in the development of osteoarthritis (OA), and vitamin D receptor (VDR) polymorphisms have been associated with several common diseases including OA by some studies. The aim of this study was to explore whether the VDR polymorphisms confer susceptibility to OA. Methods: We conducted meta-analyses on the associations between the VDR TaqI, BsmI, ApaI polymorphisms and OA using: (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) contrast of homozygotes, using fixed and random effects models. Results: A total of 10 relevant studies on VDR polymorphisms and OA were included in this meta-analysis, which involved in total 1591 OA patients and 1781 controls. Nine studies were performed on VDR TaqI polymorphisms, 6 on VDR BsmI polymorphisms, 5 on VDR ApaI polymorphisms. Accordingly, to our meta-analysis of VDR TaqI polymorphisms, no association was found between OA and the VDR TaqI T allele among in all study subjects (OR = 0.841, 95% CI = 0.663-1.067, p = 0.155). Stratification by ethnicity yielded no association between the VDR TaqI T allele and OA in Europeans or Asians. Moreover, no association was found between OA and the VDR TaqI polymorphisms by the meta-analyses of recessive and dominant models, and contrast of homozygotes. No association was found between OA and the VDR polymorphisms with respect to the BsmI and ApaI polymorphisms by meta-analyses. Conclusions: No association was found between the VDR TaqI, BsmI, or ApaI polymorphisms and OA susceptibility by this meta-analysis, which included 3372 subjects.
AB - Objective: Genetic factors may play a role in the development of osteoarthritis (OA), and vitamin D receptor (VDR) polymorphisms have been associated with several common diseases including OA by some studies. The aim of this study was to explore whether the VDR polymorphisms confer susceptibility to OA. Methods: We conducted meta-analyses on the associations between the VDR TaqI, BsmI, ApaI polymorphisms and OA using: (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) contrast of homozygotes, using fixed and random effects models. Results: A total of 10 relevant studies on VDR polymorphisms and OA were included in this meta-analysis, which involved in total 1591 OA patients and 1781 controls. Nine studies were performed on VDR TaqI polymorphisms, 6 on VDR BsmI polymorphisms, 5 on VDR ApaI polymorphisms. Accordingly, to our meta-analysis of VDR TaqI polymorphisms, no association was found between OA and the VDR TaqI T allele among in all study subjects (OR = 0.841, 95% CI = 0.663-1.067, p = 0.155). Stratification by ethnicity yielded no association between the VDR TaqI T allele and OA in Europeans or Asians. Moreover, no association was found between OA and the VDR TaqI polymorphisms by the meta-analyses of recessive and dominant models, and contrast of homozygotes. No association was found between OA and the VDR polymorphisms with respect to the BsmI and ApaI polymorphisms by meta-analyses. Conclusions: No association was found between the VDR TaqI, BsmI, or ApaI polymorphisms and OA susceptibility by this meta-analysis, which included 3372 subjects.
KW - Meta-analysis
KW - Osteoarthritis
KW - Polymorphism
KW - Vitamin D receptor
UR - http://www.scopus.com/inward/record.url?scp=61449104844&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=61449104844&partnerID=8YFLogxK
U2 - 10.1016/j.jbspin.2008.06.011
DO - 10.1016/j.jbspin.2008.06.011
M3 - Article
VL - 76
SP - 156
EP - 161
JO - Revue du Rhumatisme (English Edition)
JF - Revue du Rhumatisme (English Edition)
SN - 1169-8446
IS - 2
ER -