Weight gain associated with the α2a-adrenergic receptor -1291 C/G polymorphism and olanzapine treatment

Young Min Park, Young Cho Chung, Seung Hwan Lee, Kang Joon Lee, Hyun Kim, Young Chan Byun, Se Won Lim, Jong Woo Paik, Heon-Jeong Lee

Research output: Contribution to journalArticle

68 Citations (Scopus)


Weight gain can be an adverse effect of antipsychotics and is an important factor for long-term health and treatment compliance. Many reports have shown that the α2-adrenergic receptor may be related to eating behaviors or lipolytic activities, both associated with body weight change. We hypothesized that there might be a relationship between the α 2a-adrenergic receptor -1291 C/G polymorphism and olanzapine-induced weight gain. A group of 62 Korean schizophrenic patients participated in a study; weight and height measurements were obtained prior to starting olanzapine and measured again after long-term treatment. Genotyping for the -1291 C/G polymorphism was performed on all participants. Body weight changes from baseline to endpoint were significantly associated with genotypes (P = 0.028). The frequency of the G allele was significantly higher in subjects who had severe weight gain (defined as a more than 10% weight gain from baseline) compared to subjects who did not have extreme weight gain (less than 10% weight gain from baseline) (X2 = 6.120, P = 0.013; OR = 2.58, 95% CI = 1.21-5.51). Therefore, the findings from this study support a relationship between the -1291 C/G polymorphism of the α2a-adrenergic receptor and weight gain in Korean schizophrenic patients receiving olanzapine treatment.

Original languageEnglish
Pages (from-to)394-397
Number of pages4
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Issue number4
Publication statusPublished - 2006 Jun 5


  • α-adrenergic receptor
  • Olanzapine
  • Polymorphisms
  • Schizophrenia
  • Weight gain

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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