Well-based microfluidic chip for monitoring non-contacting cell-to-cell interactions through microchannel

Myounggun Jeon, Hey Jin Tak, Yun Kyung Kim, Eui Sung Yoon, Sehyun Shin, Il Joo Cho

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a new well-based microfluidic cell culture chip for monitoring non-contacting cell-to-cell interactions through micro-channels between chambers. The chip is fabricated with PDMS layers using SU-8 as molds. The fabricated chip was applied to monitor non-contacting cell-to-cell interaction between human glioblastoma cells and tau-engineered cells to study the association between malignant brain tumor and Alzheimer's disease (AD). Our results clearly demonstrated that the secreted components from glioblastoma cells enhanced tau aggregation. We have successfully demonstrated that the proposed well-based cell-to-cell interaction-monitoring chip can make two different cells interact through micro-channels without contacting each other using interactions between tau-BiFC cells and glioblastoma cells.

Original languageEnglish
Title of host publication2013 Transducers and Eurosensors XXVII
Subtitle of host publicationThe 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
Pages418-421
Number of pages4
DOIs
Publication statusPublished - 2013
Event2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013 - Barcelona, Spain
Duration: 2013 Jun 162013 Jun 20

Publication series

Name2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013

Other

Other2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
CountrySpain
CityBarcelona
Period13/6/1613/6/20

Keywords

  • Cell to cell interaction
  • PDMS molding
  • SU-8 mold
  • glioblastoma cell
  • microfluidic chip
  • non-contacting
  • tau aggregation

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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