Which growth parameters can affect mortality in cerebral palsy?

Hyun Jung Kim, Tae Uk Kang, Kyu Yong Park, Jihyun Kim, Hyeong Sik Ahn, Shin Young Yim

Research output: Contribution to journal › Article

Abstract

Background The objective of this study was to identify growth parameters that can affect mortality of cerebral palsy (CP). Method This was a birth cohort study based on the National Health Screening Program for Infants and Children database along with the National Health Insurance Service, which were linked using a personal identifier number. The birth cohort consisted of 2 191 956 subjects, representing 93.5% of live births from 2007-2011, with maximal 10-year follow-up (range, 5-10 years) until October 2016. Subjects with CP were identified. Growth parameters in terms of birth weight, underweight (weight-for-age below the 3rd percentile), rate of body weight gain were collected, along with all-cause mortality after the age of 1 year. Result Prevalence of CP was 2.0 per 1000 live births (95% CI, 1.94-2.06). All-cause mortality after the age of 1 year was 0.09 deaths/1000 person-years (95% CI, 0.08-0.09) in the general population (GP) and 2.85 deaths/1000 person-years (95% CI, 2.32-3.50) in subjects with CP during the follow-up. Therefore, the incidence rate ratio for all-cause mortality was 32.15 (95% CI, 25.72-39.76) in subjects with CP compared to GP. Presence of underweight was significantly associated with higher mortality in both subjects with CP and GP, where the adjusted hazard ratio of death was 2.60 (95% CI, 1.93-3.50) at the age of 18-24 months, 3.12 at 30-36 months, 4.37 at 42-48 months, 5.12 at 54-60 months, and 4.17 at 66-71 months. Birth weight did not affect mortality in both subjects with CP and GP after the age of 1 year (p < 0.05). Conclusion While subjects with CP shows higher mortality, underweight is an important growth parameter that affects all-cause mortality of both subjects with CP and GP. This study urges increased awareness that subjects with CP who are underweight require special care.

Original languageEnglish
Article numbere0218320
JournalPloS one
Volume14
Issue number6
DOIs
Publication statusPublished - 2019 Jun 1

Fingerprint

cerebral palsy
Cerebral Palsy
Mortality
Growth
underweight
Health insurance
Thinness
National Health Programs
Hazards
Screening
Health
Population
Live Birth
death
Birth Weight
birth weight
Parturition
Term Birth
health insurance
cohort studies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kim, H. J., Kang, T. U., Park, K. Y., Kim, J., Ahn, H. S., & Yim, S. Y. (2019). Which growth parameters can affect mortality in cerebral palsy? PloS one, 14(6), [e0218320]. https://doi.org/10.1371/journal.pone.0218320

Which growth parameters can affect mortality in cerebral palsy? / Kim, Hyun Jung; Kang, Tae Uk; Park, Kyu Yong; Kim, Jihyun; Ahn, Hyeong Sik; Yim, Shin Young.

In: PloS one, Vol. 14, No. 6, e0218320, 01.06.2019.

Research output: Contribution to journal › Article

Kim, HJ, Kang, TU, Park, KY, Kim, J, Ahn, HS & Yim, SY 2019, 'Which growth parameters can affect mortality in cerebral palsy?', PloS one, vol. 14, no. 6, e0218320. https://doi.org/10.1371/journal.pone.0218320
Kim HJ, Kang TU, Park KY, Kim J, Ahn HS, Yim SY. Which growth parameters can affect mortality in cerebral palsy? PloS one. 2019 Jun 1;14(6). e0218320. https://doi.org/10.1371/journal.pone.0218320
Kim, Hyun Jung ; Kang, Tae Uk ; Park, Kyu Yong ; Kim, Jihyun ; Ahn, Hyeong Sik ; Yim, Shin Young. / Which growth parameters can affect mortality in cerebral palsy?. In: PloS one. 2019 ; Vol. 14, No. 6.
@article{83cf6405573545f9a5663f000e297974,
title = "Which growth parameters can affect mortality in cerebral palsy?",
abstract = "Background The objective of this study was to identify growth parameters that can affect mortality of cerebral palsy (CP). Method This was a birth cohort study based on the National Health Screening Program for Infants and Children database along with the National Health Insurance Service, which were linked using a personal identifier number. The birth cohort consisted of 2 191 956 subjects, representing 93.5{\%} of live births from 2007-2011, with maximal 10-year follow-up (range, 5-10 years) until October 2016. Subjects with CP were identified. Growth parameters in terms of birth weight, underweight (weight-for-age below the 3rd percentile), rate of body weight gain were collected, along with all-cause mortality after the age of 1 year. Result Prevalence of CP was 2.0 per 1000 live births (95{\%} CI, 1.94-2.06). All-cause mortality after the age of 1 year was 0.09 deaths/1000 person-years (95{\%} CI, 0.08-0.09) in the general population (GP) and 2.85 deaths/1000 person-years (95{\%} CI, 2.32-3.50) in subjects with CP during the follow-up. Therefore, the incidence rate ratio for all-cause mortality was 32.15 (95{\%} CI, 25.72-39.76) in subjects with CP compared to GP. Presence of underweight was significantly associated with higher mortality in both subjects with CP and GP, where the adjusted hazard ratio of death was 2.60 (95{\%} CI, 1.93-3.50) at the age of 18-24 months, 3.12 at 30-36 months, 4.37 at 42-48 months, 5.12 at 54-60 months, and 4.17 at 66-71 months. Birth weight did not affect mortality in both subjects with CP and GP after the age of 1 year (p < 0.05). Conclusion While subjects with CP shows higher mortality, underweight is an important growth parameter that affects all-cause mortality of both subjects with CP and GP. This study urges increased awareness that subjects with CP who are underweight require special care.",
author = "Kim, {Hyun Jung} and Kang, {Tae Uk} and Park, {Kyu Yong} and Jihyun Kim and Ahn, {Hyeong Sik} and Yim, {Shin Young}",
year = "2019",
month = "6",
day = "1",
doi = "10.1371/journal.pone.0218320",
language = "English",
volume = "14",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6",

}

TY - JOUR

T1 - Which growth parameters can affect mortality in cerebral palsy?

AU - Kim, Hyun Jung

AU - Kang, Tae Uk

AU - Park, Kyu Yong

AU - Kim, Jihyun

AU - Ahn, Hyeong Sik

AU - Yim, Shin Young

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Background The objective of this study was to identify growth parameters that can affect mortality of cerebral palsy (CP). Method This was a birth cohort study based on the National Health Screening Program for Infants and Children database along with the National Health Insurance Service, which were linked using a personal identifier number. The birth cohort consisted of 2 191 956 subjects, representing 93.5% of live births from 2007-2011, with maximal 10-year follow-up (range, 5-10 years) until October 2016. Subjects with CP were identified. Growth parameters in terms of birth weight, underweight (weight-for-age below the 3rd percentile), rate of body weight gain were collected, along with all-cause mortality after the age of 1 year. Result Prevalence of CP was 2.0 per 1000 live births (95% CI, 1.94-2.06). All-cause mortality after the age of 1 year was 0.09 deaths/1000 person-years (95% CI, 0.08-0.09) in the general population (GP) and 2.85 deaths/1000 person-years (95% CI, 2.32-3.50) in subjects with CP during the follow-up. Therefore, the incidence rate ratio for all-cause mortality was 32.15 (95% CI, 25.72-39.76) in subjects with CP compared to GP. Presence of underweight was significantly associated with higher mortality in both subjects with CP and GP, where the adjusted hazard ratio of death was 2.60 (95% CI, 1.93-3.50) at the age of 18-24 months, 3.12 at 30-36 months, 4.37 at 42-48 months, 5.12 at 54-60 months, and 4.17 at 66-71 months. Birth weight did not affect mortality in both subjects with CP and GP after the age of 1 year (p < 0.05). Conclusion While subjects with CP shows higher mortality, underweight is an important growth parameter that affects all-cause mortality of both subjects with CP and GP. This study urges increased awareness that subjects with CP who are underweight require special care.

AB - Background The objective of this study was to identify growth parameters that can affect mortality of cerebral palsy (CP). Method This was a birth cohort study based on the National Health Screening Program for Infants and Children database along with the National Health Insurance Service, which were linked using a personal identifier number. The birth cohort consisted of 2 191 956 subjects, representing 93.5% of live births from 2007-2011, with maximal 10-year follow-up (range, 5-10 years) until October 2016. Subjects with CP were identified. Growth parameters in terms of birth weight, underweight (weight-for-age below the 3rd percentile), rate of body weight gain were collected, along with all-cause mortality after the age of 1 year. Result Prevalence of CP was 2.0 per 1000 live births (95% CI, 1.94-2.06). All-cause mortality after the age of 1 year was 0.09 deaths/1000 person-years (95% CI, 0.08-0.09) in the general population (GP) and 2.85 deaths/1000 person-years (95% CI, 2.32-3.50) in subjects with CP during the follow-up. Therefore, the incidence rate ratio for all-cause mortality was 32.15 (95% CI, 25.72-39.76) in subjects with CP compared to GP. Presence of underweight was significantly associated with higher mortality in both subjects with CP and GP, where the adjusted hazard ratio of death was 2.60 (95% CI, 1.93-3.50) at the age of 18-24 months, 3.12 at 30-36 months, 4.37 at 42-48 months, 5.12 at 54-60 months, and 4.17 at 66-71 months. Birth weight did not affect mortality in both subjects with CP and GP after the age of 1 year (p < 0.05). Conclusion While subjects with CP shows higher mortality, underweight is an important growth parameter that affects all-cause mortality of both subjects with CP and GP. This study urges increased awareness that subjects with CP who are underweight require special care.

UR - http://www.scopus.com/inward/record.url?scp=85067494750&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067494750&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0218320

DO - 10.1371/journal.pone.0218320

M3 - Article

C2 - 31199836

AN - SCOPUS:85067494750

VL - 14

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 6

M1 - e0218320

ER -

Access to Document